The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Open accessAbstract
The cornified layer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the external environment. Cornification is the final differentiative step for epidermal keratinocytes and involves dramatic cell condensation before death. Using conditional gene deletion in mice, we identified the transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein-1) as an important regulator of keratinocyte transition from the granular to the cornified layer. More than 250 genes are misregulated in conditional knockout epidermis, including those encoding transcription factors, signal transduction components, proteinases, and enzymes involved in lipid metabolism. Steady-state mRNA and ChIP analyses of a subset of these genes provide evidence that nfat5 , fos , prdm1 , and dusp16 are novel direct targets of Blimp-1. Identifying nfat5 as a target of Blimp-1 repression indicates that cornification involves suppression of normal osmotic regulation in granular cells. Consistently, conditional knockout mice have delayed barrier formation as embryos, enlarged granular layer cells and corneocytes, and a morphologically abnormal cornified layer. These studies provide insight into cornification, identifying transcriptional regulatory circuitry and indicating the importance of blocking osmotic homeostasis.
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“Alternatively, it has recently been suggested that Blimp1 functions in terminally differentiated sebocytes8 as well as in granular IFE cells9, 10.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [10]
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“Subsequently, it was described that terminally differentiated sebocytes8, as well as granular layer IFE keratinocytes9, 10 are marked by the Blimp1 protein.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [10]
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Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816
Kretzschmar, K., & Watt, F. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.002 · Cited by 756
Rutishauser, R. L., Martins, G. A., Kalachikov, S. M., Chandele, A., Parish, I. A., Meffre, E., Jacob, J., Calame, K. L., & Kaech, S. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.014 · Cited by 612
“…Blimp-1, a transcriptional repressor known to regulate the terminal differentiation of diverse cell types, plays a functional role in regulating effector and memory CD8+ T cellfate decisions (Horsley et al., 2006; Magnusdottir et al., 2007; Ohinata et al., 2005; Shapiro-Shelef et al., 2003).”
BackgroundInfluentialSelf-citationCretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, G. T., Smyth, G. K., Busslinger, M., Nutt, S. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2006 · Cited by 605
“6b–d ), including known Blimp-1 target genes such as Id3 and Blimp1 itsel”
Background
Metadata
- Authors
- Magnúsdóttir, E., Kalachikov, S., Mizukoshi, K., Savitsky, D., Ishida-Yamamoto, A., Panteleyev, A. A., & Calame, K.
- Affiliations
- Columbia University (US)
- Columbia Genome Center, and
- Asahikawa Medical College Hospital (JP)
- Department of Dermatology, Asahikawa Medical College, Asahikawa 078-8510, Japan
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-09-18
- Volume
- 104
- Issue
- 38
- Pages
- 14988-14993
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1986600
- OpenAlex
- W2148705591
- Semantic Scholar
- e4381d4ef6d206ca8953a70f0a5f76ffdfe8846d
- Cited by
- 152
- References
- 36
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 10 · 2016: 3 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 8
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI050659, R01 AI43576, R01-AI50659, R01AI043576)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR044535, K01 AR02204, K01AR002204)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Genetic and rare skin diseases.
- Keywords
- Blimp-1, keratinization, keratinocytes, cornified layer, transcriptional repression, conditional knockout mice, NFAT5, FOS, DUSP16, skin barrier, osmotic balance, granular layer, corneocytes, lipid metabolism
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Epidermal Cells, Animals, Cell Differentiation, Embryonic Structures, Epidermis, Humans, Phenotype, Repressor Proteins, RNA, Messenger, Transcription Factors, Keratinocytes, Proto-Oncogene Proteins c-fos, Gene Deletion, Mice, Knockout, Oligonucleotide Array Sequence Analysis, NFATC Transcription Factors, Mice, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases
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