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Anterior temporal lobes mediate semantic representation: Mimicking semantic dementia by using rTMS in normal participants
Open accessAbstract
Studies of semantic dementia and PET neuroimaging investigations suggest that the anterior temporal lobes (ATL) are a critical substrate for semantic representation. In stark contrast, classical neurological models of comprehension do not include ATL, and likewise functional MRI studies often fail to show activations in the ATL, reinforcing the classical view. Using a novel application of low-frequency, repetitive transcranial magnetic stimulation (rTMS) over the ATL, we demonstrate that the behavioral pattern of semantic dementia can be mirrored in neurologically intact participants: Specifically, we show that temporary disruption to neural processing in the ATL produces a selective semantic impairment leading to significant slowing in both picture naming and word comprehension but not to other equally demanding, nonsemantic cognitive tasks.
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“The ATL supports language as a heteromodal association area involved in the representation of concepts (Lambon Ralph et al. 2009; Pobric et al. 2007; Rogers et al. 2004) and the right ATL has been implicated in the representation of abstract social concepts (e.g., Zahn et al. 2009).”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Pobric et al. 2007
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Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Snodgrass, J. G., & Vanderwart, M. (1980) · Journal of Experimental Psychology Human Learning & Memory · doi:10.1037//0278-7393.6.2.174 · Cited by 5,604
The cortical organization of speech processing
Hickok, G., & Poeppel, D. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2113 · Cited by 5,495
Role of left inferior prefrontal cortex in retrieval of semantic knowledge: A reevaluation
Thompson‐Schill, S. L., D’Esposito, M., Aguirre, G. K., & Farah, M. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14792 · Cited by 2,137
SEMANTIC DEMENTIA: PROGRESSIVE FLUENT APHASIA WITH TEMPORAL LOBE ATROPHY
HODGES, J. R., PATTERSON, K., OXBURY, S., & FUNNELL, E. (1992) · Brain · doi:10.1093/brain/115.6.1783 · Cited by 1,710
The Representation of Object Concepts in the Brain
Martin, A. D. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.57.102904.190143 · Cited by 1,631
A neural basis for lexical retrieval
Damásio, H., Grabowski, T. J., Tranel, D., Hichwa, R. D., & Damásio, A. R. (1996) · Nature · doi:10.1038/380499a0 · Cited by 1,587
The Selective Impairment of Semantic Memory
Warrington, E. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400525 · Cited by 1,509
Semantic memory and the brain: structure and processes
Martin, A., & Chao, L. L. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00196-3 · Cited by 1,339
Rogers, T. T., & McClelland, J. L. (2004) · The MIT Press eBooks · doi:10.7551/mitpress/6161.001.0001 · Cited by 1,161
Rogers, T. T., Lambon Ralph, M. A., Garrard, P., Bozeat, S., McClelland, J. L., Hodges, J. R., & Patterson, K. (2004) · Psychological Review · doi:10.1037/0033-295x.111.1.205 · Cited by 948
Self-citationSemantic Cognition: A Parallel Distributed Processing Approach
Rogers, T. T., & McClelland, J. L. (2004) · Cited by 891
Non-verbal semantic impairment in semantic dementia
Bozeat, S., Lambon Ralph, M. A., Patterson, K., Garrard, P., & Hodges, J. R. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(00)00034-8 · Cited by 884
Self-citationThe parallel distributed processing approach to semantic cognition
McClelland, J. L., & Rogers, T. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1076 · Cited by 832
Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
Jefferies, E., & Ralph, M. A. L. (2006) · Brain · doi:10.1093/brain/awl153 · Cited by 822
Self-citationDiffering patterns of temporal atrophy in Alzheimer's disease and semantic dementia
Galton, C. J., Patterson, K., Graham, K., Lambon-Ralph, M. A., Williams, G., Antoun, N., Sahakian, B. J., & Hodges, J. R. (2001) · Neurology · doi:10.1212/wnl.57.2.216 · Cited by 582
Self-citationDevlin, J. T., Matthews, P. M., & Rushworth, M. F. S. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903321107837 · Cited by 577
Susceptibility-Induced Loss of Signal: Comparing PET and fMRI on a Semantic Task
Devlin, J. T., Russell, R. P., Davis, M. H., Price, C. J., Wilson, J. L., Moss, H. E., Matthews, P. M., & TYLER, L. K. (2000) · NeuroImage · doi:10.1006/nimg.2000.0595 · Cited by 439
Ralph, M. A. L., McClelland, J. L., Patterson, K. E., Galton, C. J., & Hodges, J. R. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/08989290151137395 · Cited by 394
Self-citationThe Temporal Lobe and Limbic System
GLOOR, P. (1997) · Medical Entomology and Zoology · Cited by 391
Declarative memory impairments in Alzheimer's disease and semantic dementia
Nestor, P. J., Fryer, T. D., & Hodges, J. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.008 · Cited by 370
The Temporal Lobe and Limbic System
Engel, J. (1998) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199805000-00038 · Cited by 340
Generating ‘tiger’ as an animal name or a word beginning with T: differences in brain activation
Mummery, C. J., Patterson, K. E., Hodges, J. R., & Wise, R. J. S. (1996) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1996.0146 · Cited by 316
Moore, C. J., & Price, C. J. (1999) · Brain · doi:10.1093/brain/122.5.943 · Cited by 288
Rogers, T. T., Hocking, J., Noppeney, U., Mechelli, A., Gorno‐Tempini, M. L., PATTERSON, K., & Price, C. J. (2006) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.6.3.201 · Cited by 265
Luzzi, S., Snowden, J. S., Neary, D., Coccia, M., Provinciali, L., & Ralph, M. A. L. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.12.008 · Cited by 239
Self-citationRalph, M. A. L., Lowe, C., & Rogers, T. T. (2006) · Brain · doi:10.1093/brain/awm025 · Cited by 237
Self-citationAttentional Functions of Parietal and Frontal Cortex
Peers, P. V., Ludwig, C. J. H., Rorden, C., Cusack, R., Bonfiglioli, C., Bundesen, C., Driver, J., Antoun, N. M., & Duncan, J. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi029 · Cited by 210
Abnormalities of language networks in temporal lobe epilepsy
Powell, R., Parker, G. J. M., Alexander, D. C., Symms, M. R., Boulby, P. A., Wheeler‐Kingshott, C. A. M. G., Barker, G. J., Koepp, M. J., & Duncan, J. S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.028 · Cited by 196
Degree of language lateralization determines susceptibility to unilateral brain lesions
Knecht, S., Flöel, A., Dräger, B., Breitenstein, C., Sommer, J. B., Henningsen, H., Ringelstein, E. B., & Pascual‐Leone, Á. (2002) · Nature Neuroscience · doi:10.1038/nn868 · Cited by 196
Noppeney, U., Patterson, K., TYLER, L. K., Moss, H. E., Stamatakis, E. A., Bright, P., Mummery, C. J., & Price, C. J. (2006) · Brain · doi:10.1093/brain/awl344 · Cited by 196
Transcranial magnetic stimulation studies of cognition: an emerging field
Jahanshahi, M., & Rothwell, J. C. (2000) · Experimental Brain Research · doi:10.1007/s002219900224 · Cited by 192
A Parametric Manipulation of Central Executive Functioning
Garavan, H. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.6.585 · Cited by 179
When objects lose their meaning: What happens to their use?
Bozeat, S., Ralph, M. A. L., PATTERSON, K., & Hodges, J. R. (2002) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.2.3.236 · Cited by 165
Self-citationRalph, M. A. L., Graham, K. S., Patterson, K. E., & Hodges, J. R. (1999) · Brain and Language · doi:10.1006/brln.1999.2143 · Cited by 158
Self-citationWise, R. J. S. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.95 · Cited by 143
Bozeat, S., Ralph, M. A. L., Graham, K. S., Patterson, K. E., Wilkin, H., Rowland, J., Rogers, T. T., & Hodges, J. R. (2003) · Cognitive Neuropsychology · doi:10.1080/02643290244000176 · Cited by 143
Self-citationCoccia, M., Bartolini, M., Luzzi, S., Provinciali, L., & Ralph, M. A. L. (2004) · Cognitive Neuropsychology · doi:10.1080/02643290342000113 · Cited by 136
Self-citationHermann, B. P., Davies, K. G., Foley, K. T., & Bell, B. D. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00821.x · Cited by 104
Hammers, A., Koepp, M. J., Richardson, M. P., Hurlemann, R., Brooks, D. J., & Duncan, J. S. (2003) · Brain · doi:10.1093/brain/awg138 · Cited by 90
Category specificity in reading and writing: the case of number words
Butterworth, B. L., Cappelletti, M., & Kopelman, M. D. (2001) · Nature Neuroscience · doi:10.1038/90484 · Cited by 71
Berthier, M. L. (2001) · Aphasiology · doi:10.1080/02687040042000179 · Cited by 64
Jefferies, E., Patterson, K. E., Jones, R. W., Bateman, D. E., & Ralph, M. A. L. (2003) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2003.10.002 · Cited by 57
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Research works printed but not linked: 2
- 10.1016/S0028-3932(00)00034-8 · DOI · Paper page
- 10.1037/0278-7393.6.2.174 · DOI
Cited by
Sorted by citations
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320
“The ATL supports language as a heteromodal association area involved in the representation of concepts (Lambon Ralph et al. 2009; Pobric et al. 2007; Rogers et al. 2004) and the right ATL has been implicated in the representation of abstract social concepts (e.g., Zahn et al. 2009).”
MethodThe neural and computational bases of semantic cognition
Ralph, M. A. L., Jefferies, E., Patterson, K., & Rogers, T. T. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.150 · Cited by 1,864
Self-citationVisser, M., Jefferies, E., & Ralph, M. A. L. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21309 · Cited by 683
Self-citationJefferies, E. (2013) · Cortex · doi:10.1016/j.cortex.2012.10.008 · Cited by 555
Self-citationNoonan, K. A., Jefferies, E., Visser, M., & Lambon Ralph, M. A. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00442 · Cited by 543
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Metadata
- Authors
- Pobric, G., Jefferies, E., & Ralph, M. A. L.
- Affiliations
- University of Manchester (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-12-11
- Volume
- 104
- Issue
- 50
- Pages
- 20137-20141
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2148435
- OpenAlex
- W2169670326
- Cited by
- 398
- References
- 43
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 11 · 2023: 15 · 2022: 22 · 2021: 22 · 2020: 27 · 2019: 31 · 2018: 22 · 2017: 26 · 2016: 28 · 2015: 28 · 2014: 21 · 2013: 21 · 2012: 25
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (078734/Z05/Z)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- anterior temporal lobe, semantic representation, semantic dementia, repetitive transcranial magnetic stimulation, semantic impairment, picture naming, word comprehension, semantic processing
- MeSH terms
- Adult, Dementia, Female, Health, Humans, Male, Semantics, Temporal Lobe, Transcranial Magnetic Stimulation
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