Cited by 474Redox biology and oxidative stressAntioxidant Activity and Oxidative StressCell death mechanisms and regulation

Molecular targets of oxidative stress

Avery, Simon V.·2011·Biochemical Journal

Abstract

Aerobic life requires organisms to resist the damaging effects of ROS (reactive oxygen species), particularly during stress. Extensive research has established a detailed picture of how cells respond to oxidative stress. Attention is now focusing on identifying the key molecular targets of ROS, which cause killing when resistance is overwhelmed. Experimental criteria used to establish such targets have differing merits. Depending on the nature of the stress, ROS cause loss of essential cellular functions or gain of toxic functions. Essential targets on which life pivots during ROS stress include membrane lipid integrity and activity of ROS-susceptible proteins, including proteins required for faithful translation of mRNA. Protein oxidation also triggers accumulation of toxic protein aggregates or induction of apoptotic cell death. This burgeoning understanding of the principal ROS targets will offer new possibilities for therapy of ROS related diseases.

Integrity signals

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Crossref · 10.1042/bj20101695

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139 of 139 references verified0 citation errors · 0 not checkable

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  • ROS in excess can provoke energy stress and metabolic failure by directly oxidizing and inactivating enzymes of the tricarboxylic acid cycle, electron transport chain, and glycolysis.

    “ROS, in excess, can provoke energy stress and metabolic failure by direct oxidizing and inactivating enzymes of the tricarboxylic acid cycle, electron transport chain (ETC), and glycolysis [62,63].”

    From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [62]

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Authors
Avery, S. V.
Affiliations
University of Nottingham (GB)
Corresponding author
Avery, Simon V.
Venue
Biochemical Journal
Published
2011-02-11
Volume
434
Issue
2
Pages
201-210
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
OpenAlex
W2010290489
Cited by
474
References
139
Citations by year
2026: 10 · 2025: 13 · 2024: 17 · 2023: 20 · 2022: 26 · 2021: 39 · 2020: 38 · 2019: 35 · 2018: 35 · 2017: 32 · 2016: 30 · 2015: 33 · 2014: 28 · 2013: 41 · 2012: 54
FWCI
4.21
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Biotechnology and Biological Sciences Research Council (BB/I000852/1)
  • Natural Environment Research Council (NE/E005969/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
oxidative stress, reactive oxygen species, membrane lipid peroxidation, protein oxidation, protein aggregation, apoptosis, translation (biology), antioxidant therapy
MeSH terms
Actins, Humans, Models, Biological, Oxidation-Reduction, Signal Transduction, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Molecular Chaperones

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