Molecular targets of oxidative stress
Abstract
Aerobic life requires organisms to resist the damaging effects of ROS (reactive oxygen species), particularly during stress. Extensive research has established a detailed picture of how cells respond to oxidative stress. Attention is now focusing on identifying the key molecular targets of ROS, which cause killing when resistance is overwhelmed. Experimental criteria used to establish such targets have differing merits. Depending on the nature of the stress, ROS cause loss of essential cellular functions or gain of toxic functions. Essential targets on which life pivots during ROS stress include membrane lipid integrity and activity of ROS-susceptible proteins, including proteins required for faithful translation of mRNA. Protein oxidation also triggers accumulation of toxic protein aggregates or induction of apoptotic cell death. This burgeoning understanding of the principal ROS targets will offer new possibilities for therapy of ROS related diseases.
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ROS in excess can provoke energy stress and metabolic failure by directly oxidizing and inactivating enzymes of the tricarboxylic acid cycle, electron transport chain, and glycolysis.
“ROS, in excess, can provoke energy stress and metabolic failure by direct oxidizing and inactivating enzymes of the tricarboxylic acid cycle, electron transport chain (ETC), and glycolysis [62,63].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [62]
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An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
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Drug-induced oxidative stress and toxicity
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AMPK, Mitochondrial Function, and Cardiovascular Disease
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Oxidatively generated complex DNA damage: Tandem and clustered lesions
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Maharjan, S., Oku, M., Tsuda, M., Hoseki, J., & Sakai, Y. (2014) · Scientific Reports · doi:10.1038/srep05896 · Cited by 212 · see citing works
- Authors
- Avery, S. V.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Avery, Simon V.
- ORCID
- Avery, Simon V.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2011-02-11
- Volume
- 434
- Issue
- 2
- Pages
- 201-210
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2010290489
- Cited by
- 474
- References
- 139
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 17 · 2023: 20 · 2022: 26 · 2021: 39 · 2020: 38 · 2019: 35 · 2018: 35 · 2017: 32 · 2016: 30 · 2015: 33 · 2014: 28 · 2013: 41 · 2012: 54
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/I000852/1)
- Natural Environment Research Council (NE/E005969/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- oxidative stress, reactive oxygen species, membrane lipid peroxidation, protein oxidation, protein aggregation, apoptosis, translation (biology), antioxidant therapy
- MeSH terms
- Actins, Humans, Models, Biological, Oxidation-Reduction, Signal Transduction, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Molecular Chaperones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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