The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration
Open accessAbstract
The hypoxia-inducible factor-1α (HIF-1α) pathway is the central regulator of adaptive responses to low oxygen availability and is required for normal skeletal development. Here, we demonstrate that the HIF-1α pathway is activated during bone repair and can be manipulated genetically and pharmacologically to improve skeletal healing. Mice lacking pVHL in osteoblasts with constitutive HIF-1α activation in osteoblasts had markedly increased vascularity and produced more bone in response to distraction osteogenesis, whereas mice lacking HIF-1 α in osteoblasts had impaired angiogenesis and bone healing. The increased vascularity and bone regeneration in the pVHL mutants were VEGF dependent and eliminated by concomitant administration of VEGF receptor antibodies. Small-molecule inhibitors of HIF prolyl hydroxylation stabilized HIF/VEGF production and increased angiogenesis in vitro . One of these molecules (DFO) administered in vivo into the distraction gap increased angiogenesis and markedly improved bone regeneration. These results identify the HIF-1α pathway as a critical mediator of neoangiogenesis required for skeletal regeneration and suggest the application of HIF activators as therapies to improve bone healing.
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Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
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Marsell, R., & Einhorn, T. A. (2011) · Injury · doi:10.1016/j.injury.2011.03.031 · Cited by 1,824
Self-citationModulation of the Inflammatory Response and Bone Healing
Maruyama, M., Rhee, C., Utsunomiya, T., Zhang, N., Ueno, M., Yao, Z., & Goodman, S. B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00386 · Cited by 541
Vascularized 3D printed scaffolds for promoting bone regeneration
Yan, Y., Chen, H., Zhang, H., Guo, C., Yang, K., Chen, K., Cheng, R., Qian, N., Sandler, N., Zhang, Y. S., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.033 · Cited by 475
Self-citationIt Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration
Grosso, A., Burger, M. G., Lunger, A., Schaefer, D. J., Banfi, A., & Di Maggio, N. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00068 · Cited by 445
Blood flow controls bone vascular function and osteogenesis
Ramasamy, S. K., Kusumbe, A. P., Schiller, M., Zeuschner, D., Bixel, M. G., Milia, C., Gamrekelashvili, J., Limbourg, A., Medvinsky, A., Santoro, M. M., et al. (2016) · Nature Communications · doi:10.1038/ncomms13601 · Cited by 429
Metadata
- Authors
- Wan, C., Gilbert, S. R., Wang, Y., Cao, X., Shen, X., Ramaswamy, G., Jacobsen, K. A., Alaql, Z. S., Eberhardt, A. W., Gerstenfeld, L. C., Einhorn, T. A., Deng, L., & Clemens, T. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-01-15
- Volume
- 105
- Issue
- 2
- Pages
- 686-691
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2139237341
- Cited by
- 515
- References
- 6
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wan, C., Gilbert, S. R., Wang, Y., Cao, X., Shen, X., Ramaswamy, G., Jacobsen, K. A., Alaql, Z. S., Eberhardt, A. W., Gerstenfeld, L. C., Einhorn, T. A., Deng, L., & Clemens, T. L. (2008). Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0708474105
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
