The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Open accessAbstract
Reactive gliosis is the universal reaction to brain injury, but the precise origin and subsequent fate of the glial cells reacting to injury are unknown. Astrocytes react to injury by hypertrophy and up-regulation of the glial-fibrillary acidic protein (GFAP). Whereas mature astrocytes do not normally divide, a subpopulation of the reactive GFAP + cells does so, prompting the question of whether the proliferating GFAP + cells arise from endogenous glial progenitors or from mature astrocytes that start to proliferate in response to brain injury. Here we show by genetic fate mapping and cell type-specific viral targeting that quiescent astrocytes start to proliferate after stab wound injury and contribute to the reactive gliosis and proliferating GFAP + cells. These proliferating astrocytes remain within their lineage in vivo , while a more favorable environment in vitro revealed their multipotency and capacity for self-renewal. Conversely, progenitors present in the adult mouse cerebral cortex labeled by NG2 or the receptor for the platelet-derived growth factor (PDGFRα) did not form neurospheres after (or before) brain injury. Taken together, the first fate-mapping analysis of astrocytes in the adult mouse cerebral cortex shows that some astrocytes acquire stem cell properties after injury and hence may provide a promising cell type to initiate repair after brain injury.
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Cites
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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The cell biology of neurogenesis
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Self-citationMultiply attenuated lentiviral vector achieves efficient gene delivery in vivo
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Astrocytes give rise to new neurons in the adult mammalian hippocampus
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“Astrocytes react to brain injury by hypertrophy of their somata and processes (5), increased synthesis of glial-fibrillary acidic protein (GFAP), or reexpression of the progenitor markers vimentin and nestin (2, 6).”
BackgroundThe role of extracellular matrix in CNS regeneration
Busch, S. A., & Silver, J. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.004 · Cited by 468
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Self-citation
Cited by
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594
Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,513
Self-citationAstrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
Metadata
- Authors
- Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-03-04
- Volume
- 105
- Issue
- 9
- Pages
- 3581-3586
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073390876
- Cited by
- 765
- References
- 8
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008). Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0709002105
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