The role of extracellular matrix in CNS regeneration
Abstract
Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.
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In healthy tissue, chondroitin sulphate proteoglycans secreted by astrocytes and oligodendrocytes create a growth-repulsive microenvironment for axons and dendrites.
“In healthy tissue, chondroitin sulphate proteoglycans are secreted by both astrocytes and oligodendrocytes to create a growth-repulsive microenvironment for axons and dendrites.1,63”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [63]
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- Authors
- Busch, S. A., & Silver, J.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Silver, Jerry
- ORCID
- Silver, Jerry
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 17
- Issue
- 1
- Pages
- 120-127
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W1970476447
- Cited by
- 468
- References
- 60
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 22 · 2020: 11 · 2019: 19 · 2018: 22 · 2017: 21 · 2016: 28 · 2015: 35 · 2014: 35 · 2013: 40 · 2012: 43
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 25713)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- extracellular matrix, central nervous system regeneration, chondroitin sulfate proteoglycans, glial scar, axon regeneration, spinal cord injury, functional recovery
- MeSH terms
- Animals, Central Nervous System, Cicatrix, Extracellular Matrix, Gliosis, Growth Inhibitors, Humans, Nerve Regeneration, Chondroitin Sulfate Proteoglycans, Spinal Cord Injuries, Growth Cones
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