The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide
Open accessAbstract
Cardiovascular (CV) research has largely been focused on two endogenously produced gaseous signaling molecules, namely, nitric oxide (NO) and carbon monoxide (CO). These gaseous messengers are both highly conserved evolutionarily and synthesized by endogenous enzyme systems. Extensive research efforts have uniformly demonstrated that CO- and NO-based therapeutics protect the brain, heart, and circulation against a number of CV disease states (1–3). However, controversy exists regarding the therapeutic value of both CO and NO, with some studies citing NO cytotoxicity at very high levels and under certain conditions (2). The toxic effects of NO are related to the highly reactive nature of NO and its interaction with superoxide to form the potent oxidant peroxynitrite (ONOO−) (2). Very recently, a third endogenously produced gaseous signaling molecule, hydrogen sulfide (H2S), has emerged as a potentially important mediator of CV homeo stasis and cytoprotection (3). In this issue of PNAS, Benavides et al. (4) reveal that the vasculoprotective and antihypertensive effects of dietary garlic (Allium sativum) are mediated in large part via the generation of H2S.
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Cites
The possible role of hydrogen sulfide as an endogenous neuromodulator
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Self-citationBoehning, D., & Snyder, S. H. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131047 · Cited by 1,225
Hydrogen sulfide mediates the vasoactivity of garlic
Benavides, G. A., Squadrito, G. L., Mills, R. W., Patel, H. D., Isbell, T. S., Patel, R. P., Darley-Usmar, V. M., Doeller, J. E., & Kraus, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705710104 · Cited by 886
Hydrogen sulfide protects neurons from oxidative stress
Kimura, Y., & Kimura, H. (2004) · The FASEB Journal · doi:10.1096/fj.04-1815fje · Cited by 874
Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation
Zanardo, R. C. O., Brancaleone, V., Distrutti, E., Fiorucci, S., Cirino, G., Wallace, J. L., Zanardo, R. C. O., Brancaleone, V., Distrutti, E., Fiorucci, S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6270fje · Cited by 859
H 2 S Induces a Suspended Animation-Like State in Mice
Blackstone, E., Morrison, M., & Roth, M. B. (2005) · Science · doi:10.1126/science.1108581 · Cited by 802
Effect of garlic on cardiovascular disorders: a review
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Free radical biology and medicine: it's a gas, man!
Pryor, W. A., Houk, K. N., Foote, C. S., Fukuto, J. M., Ignarro, L. J., Squadrito, G. L., & Davies, K. J. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00614.2005 · Cited by 465
Endogenous production of hydrogen sulfide in mammals
Kamoun, P. (2004) · Amino Acids · doi:10.1007/s00726-004-0072-x · Cited by 445
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Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Wang, Y., Zhao, X., Jin, H., Wei, H., Li, W., Bu, D., Tang, X., Ren, Y., Tang, C., & Du, J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.179333 · Cited by 307
Thiol Reactive Probes and Chemosensors
Peng, H., Chen, W., Cheng, Y., Hakuna, L., Strongin, R., & Wang, B. (2012) · Sensors · doi:10.3390/s121115907 · Cited by 275
Taking phototherapeutics from concept to clinical launch
Vickerman, B. M., Zywot, E. M., Tarrant, T. K., & Lawrence, D. S. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00326-w · Cited by 201
Metadata
- Authors
- Lefer, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-11-13
- Volume
- 104
- Issue
- 46
- Pages
- 17907-17908
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002687735
- Cited by
- 347
- References
- 18
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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