The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Flexibility in the ABC transporter MsbA: Alternating access with a twist
Open accessAbstract
ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a wide variety of substrates across cellular membranes and are conserved from bacteria to humans. Here we compare four x-ray structures of the bacterial ABC lipid flippase, MsbA, trapped in different conformations, two nucleotide-bound structures and two in the absence of nucleotide. Comparison of the nucleotide-free conformations of MsbA reveals a flexible hinge formed by extracellular loops 2 and 3. This hinge allows the nucleotide-binding domains to disassociate while the ATP-binding half sites remain facing each other. The binding of the nucleotide causes a packing rearrangement of the transmembrane helices and changes the accessibility of the transporter from cytoplasmic (inward) facing to extracellular (outward) facing. The inward and outward openings are mediated by two different sets of transmembrane helix interactions. Altogether, the conformational changes between these structures suggest that large ranges of motion may be required for substrate transport.
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4 retracted
Chang, G., & Roth, C. B. (2001) · Science · doi:10.1126/science.293.5536.1793 · Cited by 619
Self-citationRetractedChang, G. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00587-4 · Cited by 259
Self-citationRetractedStructure of the ABC Transporter MsbA in Complex with ADP·Vanadate and Lipopolysaccharide
Reyes, C. L., & Chang, G. (2005) · Science · doi:10.1126/science.1107733 · Cited by 161
Self-citationRetractedChang, G. A. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.05.001 · Cited by 22
Self-citationRetractedCrystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
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ABC Transporters: From Microorganisms to Man
Higgins, C. F. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.000435 · Cited by 3,985
Simple Allosteric Model for Membrane Pumps
JARDETZKY, O. (1966) · Nature · doi:10.1038/211969a0 · Cited by 1,291
Structure of a bacterial multidrug ABC transporter
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The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism
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Structural Biology of Rad50 ATPase
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Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P. M., Trinh, Y. T., Zhang, Q., Urbatsch, I. L., et al. (2009) · Science · doi:10.1126/science.1168750 · Cited by 1,929
Self-citationABC transporters: the power to change
Rees, D. C., Johnson, E., & Lewinson, O. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2646 · Cited by 1,450
Mechanistic diversity in ATP-binding cassette (ABC) transporters.
Locher, K. P. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3216 · Cited by 804
Function and Biogenesis of Lipopolysaccharides
Bertani, B., & Ruiz, N. (2018) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0001-2018 · Cited by 742
Biosynthesis and Export of Bacterial Lipopolysaccharides
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Metadata
- Authors
- Ward, A., Reyes, C. L., Yu, J., Roth, C. B., & Chang, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-11-27
- Volume
- 104
- Issue
- 48
- Pages
- 19005-19010
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2111935912
- Cited by
- 771
- References
- 64
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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