Cited by 241Axon Guidance and Neuronal SignalingCell death mechanisms and regulationMechanisms of cancer metastasis

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer

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Fitamant, Julien, Guenebeaud, Céline, Coissieux, Marie-May, Guix, Catherine, Treilleux, Isabelle, Scoazec, Jean-Yves, Bachelot, Thomas, Bernet, Agnès, Mehlen, Patrick·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0709810105PMC PMC2290782

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Abstract

Netrin-1, an axon navigation cue was proposed to play a crucial role during colorectal tumorigenesis by regulating apoptosis. The netrin-1 receptors DCC and UNC5H were shown to belong to the family of dependence receptors that share the ability to induce apoptosis in the absence of their ligands. Such a trait confers on these receptors a tumor suppressor activity. Expression of one of these dependence receptors at the surface of a tumor cell is indeed speculated to render this cell dependent on ligand availability for its survival, hence inhibiting uncontrolled cell proliferation or metastasis. Consequently, it is a selective advantage for a tumor cell to lose this dependence receptor activity, as previously described with losses of DCC and UNC5H expression in human cancers. However, the model predicts that a similar advantage may be obtained by gaining autocrine expression of the ligand. We describe here that, unlike human nonmetastatic breast tumors, a large fraction of metastatic breast cancers overexpress netrin-1. Moreover, we show that netrin-1-expressing mammary metastatic tumor cell lines undergo apoptosis when netrin-1 expression is experimentally decreased or when decoy soluble receptor ectodomains are added. Such treatments prevent metastasis formation both in a syngenic mouse model of lung colonization of a mammary cancer cell line and in a model of spontaneous lung metastasis of xenografted human breast tumor. Thus, netrin-1 expression observed in a large fraction of human metastatic breast tumors confers a selective advantage for tumor cell survival and potentially represents a promising target for alternative anticancer therapeutic strategies.

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RETRACTED: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion
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Retracted
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Authors: Fitamant, J., Guenebeaud, C., Coissieux, M.-M., Guix, C., Treilleux, I., Scoazec, J.-Y., Bachelot, T., Bernet, A., & Mehlen, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
Inserm (FR)
Lyon 1 Université (FR)
Corresponding author: Mehlen, Patrick
ORCID: Coissieux, Marie-May
Treilleux, Isabelle
Scoazec, Jean-Yves
Bachelot, Thomas
Bernet, Agnès
Mehlen, Patrick
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-03-25
Volume: 105
Issue: 12
Pages: 4850-4855
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0709810105
PMC: PMC2290782
OpenAlex: W1980116118
Cited by: 241
References: 36
Citations by year: 2026: 7 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 10 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 13 · 2016: 13 · 2015: 11 · 2014: 14 · 2013: 15 · 2012: 13
FWCI: 6.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Agence Nationale de la Recherche
Institut National de la Santé et de la Recherche Médicale
Ligue Contre le Cancer
Centre National de la Recherche Scientifique
Institut National Du Cancer
Université de Lyon
Goddard Space Flight Center
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: netrin-1, metastatic breast cancer, dependence receptors, DCC receptor, apoptosis, tumor cell survival, lung metastasis, tumor suppressor activity, cancer therapy targets
MeSH terms: Netrin-1, Animals, Breast Neoplasms, Cell Survival, Female, Humans, Lung Neoplasms, Neoplasm Metastasis, Neoplasm Transplantation, Nerve Growth Factors, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Cell Death, Autocrine Communication, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Cell Line, Tumor, Mice

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Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer

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