The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
Open accessAbstract
Netrin-1, an axon navigation cue was proposed to play a crucial role during colorectal tumorigenesis by regulating apoptosis. The netrin-1 receptors DCC and UNC5H were shown to belong to the family of dependence receptors that share the ability to induce apoptosis in the absence of their ligands. Such a trait confers on these receptors a tumor suppressor activity. Expression of one of these dependence receptors at the surface of a tumor cell is indeed speculated to render this cell dependent on ligand availability for its survival, hence inhibiting uncontrolled cell proliferation or metastasis. Consequently, it is a selective advantage for a tumor cell to lose this dependence receptor activity, as previously described with losses of DCC and UNC5H expression in human cancers. However, the model predicts that a similar advantage may be obtained by gaining autocrine expression of the ligand. We describe here that, unlike human nonmetastatic breast tumors, a large fraction of metastatic breast cancers overexpress netrin-1. Moreover, we show that netrin-1-expressing mammary metastatic tumor cell lines undergo apoptosis when netrin-1 expression is experimentally decreased or when decoy soluble receptor ectodomains are added. Such treatments prevent metastasis formation both in a syngenic mouse model of lung colonization of a mammary cancer cell line and in a model of spontaneous lung metastasis of xenografted human breast tumor. Thus, netrin-1 expression observed in a large fraction of human metastatic breast tumors confers a selective advantage for tumor cell survival and potentially represents a promising target for alternative anticancer therapeutic strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“(1) upregulating the expression of their cognate ligands such as NTN1 [360–362]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [360]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Hong, K., Hinck, L., Nishiyama, M., Poo, M.-M., Tessier‐Lavigne, M., & Stein, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80804-1 · Cited by 684
RetractedGene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,760
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.
Serafini, T., Kennedy, T. E., Gaiko, M. J., Mirzayan, C., Jessell, T., & Tessier-Lavigne, M. (1994) · Cell · doi:10.1016/0092-8674(94)90420-0 · Cited by 1,397
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.
Serafini, T., Colamarino, S., Leonardo, E., Wang, H., Beddington, R., Skarnes, W., & Tessier-Lavigne, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81795-x · Cited by 1,328
Aslakson, C. J., & Miller, F. R. (1992) · PubMed · Cited by 1,234
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.
Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E., Chan, S., Culotti, J., & Tessier-Lavigne, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81336-7 · Cited by 1,048
de Kok, J. B., Roelofs, R., Giesendorf, B. A. J., Pennings, J. L. A., Waas, E. T., Feuth, T. B., Swinkels, D. W., & Span, P. N. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700208 · Cited by 580
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
van Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., Parathath, S., Distel, E., Feig, J. L., Alvarez-Leite, J. I., et al. (2012) · Nature Immunology · doi:10.1038/ni.2205 · Cited by 365
Cancer-Associated Neurogenesis and Nerve-Cancer Cross-talk
Silverman, D. A., Martinez, V. K., Dougherty, P. M., Myers, J. N., Călin, G. A., & Amit, M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2793 · Cited by 304
Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
Mehlen, P., Delloye‐Bourgeois, C., & Chédotal, A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3005 · Cited by 301
Self-citationNetrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Ramkhelawon, B., Hennessy, E. J., Ménager, M. M., Ray, T. D., Sheedy, F. J., Hutchison, S. B., Wanschel, A. C. B. A., Oldebeken, S. R., Geoffrion, M., Spiro, W., et al. (2014) · Nature Medicine · doi:10.1038/nm.3467 · Cited by 280
Dependence receptors: a new paradigm in cell signaling and cancer therapy
Goldschneider, D., & Mehlen, P. (2010) · Oncogene · doi:10.1038/onc.2010.13 · Cited by 169
Self-citationGenetics of cleft lip and/or cleft palate: Association with other common anomalies
Setó‐Salvia, N., & Stanier, P. (2014) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2014.04.003 · Cited by 174
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer
Cassier, P. A., Navaridas, R., Bellina, M., Rama, N., Ducarouge, B., Hernández‐Vargas, H., Delord, J., Lengrand, J., Paradisi, A., Fattet, L., et al. (2023) · Nature · doi:10.1038/s41586-023-06367-z · Cited by 166
Self-citationThe neuronal influence on tumor progression
Mancino, M., Ametller, E., Gascón, P., & Almendro, V. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.04.005 · Cited by 159
Inhibition of Endothelial Cell Apoptosis by Netrin-1 during Angiogenesis
Castets, M., Coissieux, M., Delloye‐Bourgeois, C., Bernard, L., Delcros, J., Bernet, A., Laudet, V., & Mehlen, P. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.006 · Cited by 169
Self-citationCD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development
Tu, T., Zhang, C., Yan, H., Luo, Y., Kong, R., Wen, P., Ye, Z., Chen, J., Feng, J., Liu, F., et al. (2015) · Cell Research · doi:10.1038/cr.2015.15 · Cited by 158
UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans
Ziel, J. W., Hagedorn, E. J., Audhya, A., & Sherwood, D. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1825 · Cited by 147
Pharmacological targeting of netrin-1 inhibits EMT in cancer
Lengrand, J., Pastushenko, I., Vanuytven, S., Song, Y., Venet, D., Sarate, R. M., Bellina, M., Moers, V., Boinet, A., Sifrim, A., et al. (2023) · Nature · doi:10.1038/s41586-023-06372-2 · Cited by 163
Self-citationInterference With Netrin-1 and Tumor Cell Death in Non–Small Cell Lung Cancer
Delloye‐Bourgeois, C., Brambilla, E. M., Coissieux, M., Guenebeaud, C., Pedeux, R., Firlej, V., Cabon, F., Brambilla, C., Mehlen, P., & Bernet, A. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn491 · Cited by 171
Self-citationGuenebeaud, C., Goldschneider, D., Castets, M., Guix, C., Chazot, G., Delloye-Bourgeois, C., Eisenberg-Lerner, A., Shohat, G., Zhang, M., Laudet, V., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.021 · Cited by 137
Self-citationNetrin-1 acts as a survival factor for aggressive neuroblastoma
Delloye‐Bourgeois, C., Fitamant, J., Paradisi, A., Cappellen, D., Douc‐Rasy, S., Raquin, M., Stupack, D. G., Nakagawara, A., Rousseau, R. F., Combaret, V., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082299 · Cited by 171
Self-citationHagedorn, E. J., Yashiro, H., Ziel, J. W., Ihara, S., Wang, Z., & Sherwood, D. R. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.006 · Cited by 133
Luchino, J., Hocine, M., Amoureux, M., Gibert, B., Bernet, A., Royet, A., Treilleux, I., Lécine, P., Borg, J., Mehlen, P., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.09.010 · Cited by 129
Self-citationStructural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers
Grandin, M., Meier, M., Delcros, J. G., Nikodemus, D., Reuten, R., Patel, T. R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.01.001 · Cited by 128
Self-citationThe netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo
Hagedorn, E. J., Ziel, J. W., Morrissey, M. A., Linden, L. M., Wang, Z., Chi, Q., Johnson, S. A., & Sherwood, D. R. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201301091 · Cited by 127
Dumartin, L., Quemener, C., Laklai, H., Herbert, J. M. J., Bicknell, R., Bousquet, C., Pyronnet, S., Castronovo, V., Schilling, M. K., Bikfalvi, A., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.061 · Cited by 126
Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity
Sung, P., Rama, N., Imbach, J., Fiore, S., Ducarouge, B., Neves, D., Chen, H., Bernard, D., Yang, P., Bernet, A., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2952 · Cited by 117
Self-citationShimizu, A., Nakayama, H., Wang, P., König, C., Akino, T., Sandlund, J., Coma, S., Italiano, J. E., Mammoto, A., Bielenberg, D. R., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.397398 · Cited by 103
Ballard, M. S., & Hinck, L. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-386503-8.00005-3 · Cited by 105
Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor
Wang, R., Wei, Z., Jin, H., Wu, H., Yu, C., Wen, W., Chan, L.-N., Wen, Z., & Zhang, M. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.016 · Cited by 109
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours
Krimpenfort, P., Song, J., Proost, N., Zevenhoven, J., Jonkers, J., & Berns, A. J. M. (2012) · Nature · doi:10.1038/nature10790 · Cited by 93
Netrin-1 and its dependence receptors as original targets for cancer therapy
Mehlen, P., & Guenebeaud, C. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328333dcd1 · Cited by 103
Self-citationParadisi, A., Maisse, C., Bernet, A., Coissieux, M., Maccarrone, M., Scoazec, J., & Mehlen, P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.080 · Cited by 87
Self-citationCancer models in Caenorhabditis elegans
Kirienko, N. V., Mani, K., & Fay, D. S. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22247 · Cited by 87
Navigating Breast Cancer: Axon Guidance Molecules as Breast Cancer Tumor Suppressors and Oncogenes
Harburg, G. C., & Hinck, L. (2011) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-011-9225-1 · Cited by 81
SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane
Morrissey, M. A., Jayadev, R., Miley, G. R., Blebea, C. A., Chi, Q., Ihara, S., & Sherwood, D. R. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005905 · Cited by 78
Akino, T., Han, X., Nakayama, H., McNeish, B. L., Zurakowski, D., Mammoto, A., Klagsbrun, M., & Smith, E. R. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3116 · Cited by 79
Netrin-1 is a survival factor during commissural neuron navigation
Furne, C., Rama, N., Corset, V., Chédotal, A., & Mehlen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803645105 · Cited by 77
Self-citationNetrin-1 Simultaneously Suppresses Corneal Inflammation and Neovascularization
Han, Y., Shao, Y., Lin, Z., Qu, Y., Wang, H., Zhou, Y., Chen, W., Chen, Y., Chen, W., Hu, F., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8722 · Cited by 74
Dependence Receptors and Cancer: Addiction to Trophic Ligands
Gibert, B., & Mehlen, P. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3652 · Cited by 73
Self-citationDependence Receptors: From Basic Research to Drug Development
Mehlen, P., & Bredesen, D. E. (2011) · Science Signaling · doi:10.1126/scisignal.2001521 · Cited by 72
Self-citationNetrin-1 Overexpression Protects Kidney from Ischemia Reperfusion Injury by Suppressing Apoptosis
Wang, W., Reeves, W. B., Pays, L., Mehlen, P., & Ramesh, G. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090224 · Cited by 74
Self-citationCross-repressive interactions betweenLrig3and netrin 1 shape the architecture of the inner ear
Abraira, V. E., del Rio, T., Tucker, A. F., Slonimsky, J., Keirnes, H. L., & Goodrich, L. V. (2008) · Development · doi:10.1242/dev.029330 · Cited by 70
Plasma netrin-1 is a diagnostic biomarker of human cancers
Ramesh, G., Berg, A. S., & Jayakumar, C. (2011) · Biomarkers · doi:10.3109/1354750x.2010.541564 · Cited by 74
Dependence receptor TrkC is a putative colon cancer tumor suppressor
Genevois, A.-L., Ichim, G., Coissieux, M., Lambert, M.-P., Lavial, F., Goldschneider, D., Jarrosson, L., Lépinasse, F., Gouysse, G., Herceg, Z., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212333110 · Cited by 68
Self-citationExosomal Induction of Tumor Innervation
Vermeer, P. D. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3995 · Cited by 66
Interfering with multimerization of netrin-1 receptors triggers tumor cell death
Mille, F., Llambi, F., Guix, C., Delloye‐Bourgeois, C., Guenebeaud, C., Castro‐Obregón, S., Bredesen, D. E., Thibert, C., & Mehlen, P. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.75 · Cited by 83
Self-citationCombining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death
Paradisi, A., Creveaux, M., Gibert, B., Devailly, G., Redoulez, E., Neves, D., Cleyssac, E., Treilleux, I., Klein, C., Niederfellner, G. J., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302654 · Cited by 63
Self-citationWang, W., Reeves, W. B., & Ramesh, G. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90686.2008 · Cited by 61
Son, T., Yun, S. P., Yong, M. S., Seo, B., Ryu, J. M., Youn, H. Y., Oh, Y., & Han, H. J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.94 · Cited by 61
Liu, W., Vivian, C. J., Brinker, A. E., Hampton, K. R., Lianidou, E. S., & Welch, D. R. (2014) · Cancer Microenvironment · doi:10.1007/s12307-014-0148-4 · Cited by 60
Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation
Delloye‐Bourgeois, C., Goldschneider, D., Paradisi, A., Thérizols, G., Belin, S., Hacot, S., Rosa‐Calatrava, M., Scoazec, J., Diaz, J., Bernet, A., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2002456 · Cited by 71
Self-citationCrosstalk between the peripheral nervous system and breast cancer influences tumor progression
Hu, J., Chen, W., Shen, L., Chen, Z., & Huang, J. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188828 · Cited by 59
The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor
Wang, H., Boussouar, A., Mazelin, L., Tauszig-Delamasure, S., Sun, Y., Goldschneider, D., Paradisi, A., & Mehlen, P. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.040 · Cited by 59
Self-citationRb/E2F Regulates Expression of Neogenin during Neuronal Migration
Andrusiak, M. G., McClellan, K. A., Dugal-Tessier, D., Julian, L. M., Rodrigues, S., Park, D. S., Kennedy, T. E., & Slack, R. S. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00378-10 · Cited by 61
The functions and regulations of DAPK in cancer metastasis
Chen, H., Lee, Y.-R., & Chen, R. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0923-6 · Cited by 57
Cdo Interacts with APPL1 and Activates AKT in Myoblast Differentiation
Bae, G., Lee, J.-R., Kim, B.-G., Han, J., Leem, Y.-E., Lee, H.-J., Ho, S., Hahn, M., & Kang, J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-12-1011 · Cited by 55
The tumor-nerve circuit in breast cancer
Cui, Q., Jiang, D., Zhang, Y., & Chen, C. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10095-1 · Cited by 55
Netrin-1 overexpression is predictive of ovarian malignancies
Papanastasiou, A. D., Pampalakis, G., Katsaros, D., & Sotiropoulou, G. (2011) · Oncotarget · doi:10.18632/oncotarget.258 · Cited by 55
Dependence receptors: new targets for cancer therapy
Brisset, M., Grandin, M., Bernet, A., Mehlen, P., & Hollande, F. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114495 · Cited by 57
Self-citationNetrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression
Boussouar, A., Tortereau, A., Manceau, A., Paradisi, A., Gadot, N., Vial, J., Neves, D., Larue, L., Battistella, M., Lebœuf, C., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1590 · Cited by 56
Self-citationYin, K., Wang, L., Zhang, X., He, Z., Xia, Y., Xu, J., Wei, S., Li, B., Li, Z., Sun, G., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17750 · Cited by 51
RetractedDifferential expression of neurogenes among breast cancer subtypes identifies high risk patients
Fernández‐Nogueira, P., Bragado, P., Almendro, V., Ametller, E., Ríos, J., Choudhury, S. A., Mancino, M., & Gascón, P. (2015) · Oncotarget · doi:10.18632/oncotarget.6543 · Cited by 48
Comparison of breast cancer metastasis models reveals a possible mechanism of tumor aggressiveness
Pillar, N., Polsky, A. L., Weissglas‐Volkov, D., & Shomron, N. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1094-8 · Cited by 51
Guidance molecules in lung cancer
Nasarre, P., Potiron, V. A., Drabkin, H. A., & Roche, J. (2010) · Cell Adhesion & Migration · doi:10.4161/cam.4.1.10882 · Cited by 49
Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner
Causeret, F., Sumia, I., & Pierani, A. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.100 · Cited by 57
Netrin-1 in cancer: Potential biomarker and therapeutic target?
Kefeli, U., Kefeli, A. Ü., Çabuk, D., Işık, U., Sonkaya, A., Açıkgöz, Ö., Özden, E., & Uygun, K. (2017) · Tumor Biology · doi:10.1177/1010428317698388 · Cited by 49
Ducarouge, B., Redavid, A. R., Victoor, C., Chira, R., Fonseca, A., Hervieu, M., Bergé, R., Lengrand, J., Vieugué, P., Neves, D., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01209-x · Cited by 46
Self-citationHan, P., Fu, Y., Liu, J., Wang, Y., He, J., Gong, J., Li, M., Tan, Q., Li, D., Luo, Y., et al. (2015) · Europe PMC (PubMed Central) · Cited by 48
Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome
Auer, K., Bachmayr-Heyda, A., Aust, S., Sukhbaatar, N., Reiner, A. T., Grimm, C., Horvat, R., Zeillinger, R., & Pils, D. (2015) · Oncotarget · doi:10.18632/oncotarget.3746 · Cited by 46
Dependence receptors – the dark side awakens
Negulescu, A., & Mehlen, P. (2018) · FEBS Journal · doi:10.1111/febs.14507 · Cited by 58
Self-citationYan, W., Han, P., Zhou, Z., Tu, W., Liao, J., Li, P., Liu, M., Tian, D., & Fu, Y. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-3016-z · Cited by 45
Dependence receptors and colorectal cancer
Mehlen, P., & Tauszig-Delamasure, S. (2014) · Gut · doi:10.1136/gutjnl-2013-306704 · Cited by 44
Self-citationLarrieu-Lahargue, F., Welm, A. L., Bouchecareilh, M., Alitalo, K. K., Li, D. Y., Bikfalvi, A., & Auguste, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039540 · Cited by 44
Galardi, A., Colletti, M., Lavarello, C., Paolo, V. D., Mascio, P. D., Russo, I., Cozza, R., Romanzo, A., Valente, P., Vito, R. D., et al. (2020) · Cancers · doi:10.3390/cancers12061555 · Cited by 44
Netrin-1 promotes glioma growth by activating NF-κB via UNC5A
Chen, J.-Y., He, X.-X., Ma, C., Wu, X.-M., Wan, X.-L., Xing, Z., Pei, Q.-Q., Dong, X., Liu, D., Xiong, W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05707-0 · Cited by 42
Harter, P. N., Zinke, J., Scholz, A., Tichy, J., Zachskorn, C., Kvasnicka, H. M., Goeppert, B., Delloye-Bourgeois, C., Hattingen, E., Senft, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092311 · Cited by 41
Self-citationNetrin Family: Role for Protein Isoforms in Cancer
Bruikman, C. S., Zhang, H., Kemper, A. M., & van Gils, J. M. (2019) · Journal of Nucleic Acids · doi:10.1155/2019/3947123 · Cited by 43
Netrin-1: A regulator of cancer cell motility?
Ylivinkka, I., Keski‐Oja, J., & Hyytiäinen, M. M. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.10.002 · Cited by 41
Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference
Grandin, M., Mathot, P., Devailly, G., Bidet, Y., Ghantous, A., Favrot, C., Gibert, B., Gadot, N., Puisieux, I., Herceg, Z., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505945 · Cited by 39
Self-citationCrosstalk between cancer cells and the nervous system
Huang, M., Gong, G., Deng, Y., Long, X., Long, W., Liu, Q., Zhao, W., & Chen, R. (2023) · Medicine Advances · doi:10.1002/med4.27 · Cited by 41
Dudgeon, C., Casabianca, A., Harris, C. R., Ogier, C., Bellina, M., Fiore, S., Bernet, A., Ducarouge, B., Goldschneider, D., Su, X., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113369 · Cited by 37
Self-citationNetrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer
Lv, B., Song, C., Wu, L., Zhang, Q., Hou, D., Chen, P., Yu, S., Wang, Z., Chu, Y., Zhang, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3400 · Cited by 39
Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness
Ylivinkka, I., Sihto, H. J., Tynninen, O., Hu, Y., Laakso, A., Kivisaari, R. P., Laakkonen, P. M., Keski‐Oja, J., & Hyytiäinen, M. M. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0482-0 · Cited by 39
Netrin-1 and its receptors in tumour growth promotion
Bernet, A., & Fitamant, J. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.8.995 · Cited by 43
Self-citationCD151 mediates netrin‐1‐induced angiogenesis through the Src‐FAK‐Paxillin pathway
Yang, X., Li, S., Zhong, J., Zhang, W., Hua, X., Li, B., & Sun, H. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12939 · Cited by 38
The role of Sox6 and Netrin-1 in ovarian cancer cell growth, invasiveness, and angiogenesis
Li, Y., Xiao, M., & Guo, F.-C. (2017) · Tumor Biology · doi:10.1177/1010428317705508 · Cited by 37
Netrin-1 Promotes the Immunosuppressive Activity of MDSCs in Colorectal Cancer
Xia, X., Mao, Z., Wang, W., Ma, J., Tian, J., Wang, S., & Yin, K. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0658 · Cited by 39
Macrophage-derived netrin-1 contributes to endometriosis- associated pain
Ding, S., Guo, X., Zhu, L., Wang, J., Li, T., Yu, Q., & Zhang, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-2161 · Cited by 35
Ben-David-Naim, M., Grad, E., Aizik, G., Nordling‐David, M. M., Moshel, O., Granot, Z., & Golomb, G. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.036 · Cited by 37
MUC4-promoted neural invasion is mediated by the axon guidance factor netrin-1 in PDAC
Wang, L., Zhi, X., Zhu, Y., Zhang, Q., Wang, W., Li, Z., Tang, J., Wang, J., Wei, S., Li, B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5668 · Cited by 36
Unraveling the Role of Huntingtin in Breast Cancer Metastasis
Thion, M. S., McGuire, J. R., Sousa, C. M., Fuhrmann, L., Fitamant, J., Leboucher, S., Vacher, S., du Montcel, S. T., Bièche, I., Bernet, A., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv208 · Cited by 35
Self-citationWischhusen, J. C., Wilson, K. E., Delcros, J., Molina-Peña, R., Gibert, B., Jiang, S., Ngo, J., Goldschneider, D., Mehlen, P., Willmann, J. K., et al. (2018) · Theranostics · doi:10.7150/thno.27221 · Cited by 37
Self-citationLahlali, T., Plissonnier, M., Romero‐López, C., Michelet, M., Ducarouge, B., Berzal‐Herranz, A., Zoulim, F., Mehlen, P., & Parent, R. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.12.011 · Cited by 36
Self-citationRajarajan, D., Selvarajan, S., Raja, M. R. C., Mahapatra, S. K., & Kasiappan, R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28428 · Cited by 34
Roles for netrin signaling outside of axon guidance: A view from the worm
Ziel, J. W., & Sherwood, D. R. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22225 · Cited by 33
Wu, S., Guo, X., Zhou, J., Zhu, X., Chen, H., Zhang, K., Lu, Y., & Chen, Y. (2020) · Aging · doi:10.18632/aging.103639 · Cited by 33
Cell invasion through basement membrane
Morrissey, M. A., Hagedorn, E. J., & Sherwood, D. R. (2013) · Worm · doi:10.4161/worm.26169 · Cited by 32
Netrin-1 induced activation of Notch signaling mediates glioblastoma cell invasion
Ylivinkka, I., Hu, Y., Chen, P., Rantanen, V., Hautaniemi, S., Nyman, T. A., Keski‐Oja, J., & Hyytiäinen, M. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.120022 · Cited by 32
Ma, W., Shang, Y., Wei, Z., Wen, W., Wang, W., & Zhang, M. (2010) · Structure · doi:10.1016/j.str.2010.08.011 · Cited by 31
PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer
Liu, J., Kong, C., Gong, D.-X., Zhang, Z., & Zhu, Y. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-93 · Cited by 31
Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
Ko, S. Y., Blatch, G. L., & Dass, C. R. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9459-z · Cited by 30
Characterization and Expression of Netrin-1 and Its Receptors UNC5B and DCC in Human Placenta
Dakouane‐Giudicelli, M., Duboucher, C., Fortemps, J., Missey-Kolb, H., Brulle, D., Giudicelli, Y., & de Mazancourt, P. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953463 · Cited by 28
Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
Broutier, L., Creveaux, M., Vial, J., Tortereau, A., Delcros, J., Chazot, G., McCarron, M. J., Goddard‐Léon, S., Pangault, C., Gadot, N., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505480 · Cited by 28
Self-citationRETRACTED: Netrin-1 promotes metastasis of gastric cancer by regulating YAP activity
Yin, K., Dang, S., Cui, L., Fan, X., Xie, R., Qu, J., Shang, M., & Chen, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.170 · Cited by 28
Retracted
Metadata
- Authors
- Fitamant, J., Guenebeaud, C., Coissieux, M.-M., Guix, C., Treilleux, I., Scoazec, J.-Y., Bachelot, T., Bernet, A., & Mehlen, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Lyon 1 Université (FR)
- Corresponding author
- Mehlen, Patrick
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-03-25
- Volume
- 105
- Issue
- 12
- Pages
- 4850-4855
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2290782
- OpenAlex
- W1980116118
- Cited by
- 241
- References
- 36
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 10 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 13 · 2016: 13 · 2015: 11 · 2014: 14 · 2013: 15 · 2012: 13
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Centre National de la Recherche Scientifique
- Institut National Du Cancer
- Université de Lyon
- Goddard Space Flight Center
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- netrin-1, metastatic breast cancer, dependence receptors, DCC receptor, apoptosis, tumor cell survival, lung metastasis, tumor suppressor activity, cancer therapy targets
- MeSH terms
- Netrin-1, Animals, Breast Neoplasms, Cell Survival, Female, Humans, Lung Neoplasms, Neoplasm Metastasis, Neoplasm Transplantation, Nerve Growth Factors, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Cell Death, Autocrine Communication, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
