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Neuregulin 1 and Susceptibility to Schizophrenia

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

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Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

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Neurobiology of Schizophrenia

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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

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Bace1 modulates myelination in the central and peripheral nervous system

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Blocking the phosphatidylinositol 3-kinase pathway inhibits neuregulin-1-mediated rescue of neurotoxicity induced by Aβ1–42

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Lack of β-amyloid cleaving enzyme-1 (BACE1) impairs long-term synaptic plasticity but enhances granule cell excitability and oscillatory activity in the dentate gyrus in vivo

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The neurobiology of transition to psychosis: clearing the cache

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Translational Control of BACE1 May Go Awry in Alzheimer's Disease

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Association analysis of ANK3 gene variants with schizophrenia in a northern Chinese Han population

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Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice

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Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway

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Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis

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Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk

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Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor

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Is psychosis a dysmyelination-related information-processing disorder?

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Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801

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Increased TNFR1 expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity

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Nrg1 Reverse Signaling in Cortical Pyramidal Neurons

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Importance of Control Groups for Evaluating Long-Term Behavioral and Cognitive Outcomes of Controlled Cortical Impact in Immature Rats

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A gender dimorphism in up-regulation of BACE1 gene expression in schizophrenia

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BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?

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Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

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Biological Mechanism-based Neurology and Psychiatry: A BACE1/2 and Downstream Pathway Model

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Finding New Ways How to Control BACE1

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Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system

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Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease

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Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

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The Ups and Downs of BACE1: Walking a Fine Line between Neurocognitive and Other Psychiatric Symptoms of Alzheimer’s Disease

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Troubleshooting methods for APP processing in vitro

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Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme

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Constitutive loss and acute pharmacological manipulation of ErbB4 signaling do not affect attention and inhibitory control in mice

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Physiological and behavioral effects of amphetamine in BACE1 −/−mice

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Seizure-6 proteins highlight BACE1 functions in neurobiology

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BACE1 : Biological Functions and Involvement in the Pathophysiology of Alzheimer's Disease and Other Neurological Disorders

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Proteases in the Nervous System

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Rafts, Nanoparticles and Neural Disease

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Proposed Therapeutic Strategy to Combat Alzheimer’s Disease by Targeting Beta and Gamma Secretases

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BACE1 in PV interneuron tunes hippocampal CA1 local circuits and resets priming of fear memory extinction

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Comparative studies of amyloid properties of muscles proteins and brain Aβ-peptides and identification of approaches to destruction of their amyloids in vitro

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β-Secretase Inhibition

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Association of β-Secretase Functional Polymorphism with Risk of Schizophrenia

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Clinical Considerations: Assessment and Treatment

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Role of BACE1 in Cognitive Function, from Alzheimer’s Disease to Traumatic Brain Injury

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Aspartic Proteases of Alzheimer’s Disease: β- and γ-Secretases

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Alzheimer’s Disease and Mechanism-Based Attempts to Enhance Cognition

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Elevated peripheral Neuregulin-1 protein levels in non-medicated focal epilepsy patients

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Catabolism and Anabolism of Amyloid-β

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Targets and Strategies Toward the Development of Alzheimer Therapeutics

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Die Amyloidablagerung in einem Mausmodell der Alzheimer Demenz und die Modulation der β-Amyloid-Peptidentstehung durch membranverankerte Inhibitoren

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AMIGO and its friends in developing and adult brain

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Animal Models and Procedures for CNS Disorders

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Characterising transgenic APP mutation mouse models of amyloid pathology for use in preclinical immunotherapy

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BACE1 Inhibitors: Attractive Therapeutics for Alzheimer’s Disease

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ReducedBACE1ActivityEnhancesClearanceofMyelin DebrisandRegenerationofAxonsintheInjuredPeripheral NervousSystem

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A Non-Canonical Role for Choline Acetyltransferase in Chromatin Organization and the Response to Beta-Amyloid

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The microrna-mediated regulation of proteins implicated in the pathogenesis of Alzheimer's Disease

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Nanoparticle Based siRNA Delivery to the Central Nervous System: A Potential Therapeutic Approach

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BACE1 is a novel regulator of Th17 function in EAE

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Association and interplay of genetic and epigenetic variants in smoking behavior

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METAPLASTICITY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE AND POSSIBLE THERAPEUTIC INTERVENTIONS

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Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease

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Designing and preparation of new BACE1 inhibitors for Alzheimer's disease treatment

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Change in Ratio of Platelet Beta-Amyloid Precursor Protein (APP) Forms in Schizophrenia Compared with Control Group

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The effect of genes and diet on Alzheimer's disease-related molecular mechanisms : Influence of ubiquilin-1 and dietary lipids

Takalo, M. (2015) · UEF eRepo (University of Eastern Finland)

Differential effects on typical and atypical antipsychotics on the expression of neuregulin-1 and ErbB4 receptors

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Cleaving schizophrenia

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Aspartic Proteases of Alzheimer's Disease: β- and γ--Secretases

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Tryptamine Derivatives of Sesquiterpene Lactones as Effective β-Secretase 1 Inhibitors

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Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 gene

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Physiological and pathological roles of the amyloid precursor protein at the presynapse

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Contribution à l'étude des facteurs de risque pour la maladie d'Alzheimer : analyse de candidats identifiés par étude d'association pangénomique ou GWAS

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Beta-Secretase Inhibitors

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BACE1 Inhibitors: Design, Synthesis, Structure–Activity Relationships, and Therapeutic Applications in Alzheimer’s Disease and Beyond – An Updated Review

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Evolution of Synthetic Strategies for Lilly’s Clinical BACE Inhibitors: From Discovery Concepts to Manufacturing-Ready Routes

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Deep Mechanistic Models reveal pathway-extrinsic drivers of mammary MAPK signalling heterogeneityPreprint

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Targeting the BACE1–GSK-3β Signaling Axis in Alzheimer’s Disease: From Molecular Crosstalk to Nanotechnology-Based Translational Strategies

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Quest for specific plant BACE1 inhibitors by in silico methodsPreprint

Nahálková, J. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7610671

BindingDB Entry 50039593: New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.

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BindingDB Entry 50046923: Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

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Development and validation of transgene constructs in order to generate bi-transgenic mice models for Diabetic Peripheral Neuropathy research

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Investigation of BACE1 as a stress-induced regulator of neuronal metabolism

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BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia

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1570 – Cleavage Of Neuregulin 1 And Bace1 Expression In Frontal Cortex Of Schizophrenia Patients

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Neurological dysfunctions associated with altered BACE 1‐dependent Neuregulin‐1 signaling

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