Cited by 291Schizophrenia research and treatmentAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1 -null mice

Open access

Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., Wong, P. C.·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0710373105PMC PMC2291091

Open this paper in CoChat — free account

Abstract

beta-Site APP-cleaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-beta precursor protein (APP) leading to the generation of amyloid-beta peptides that is central to the pathogenesis of Alzheimer's disease. In addition to its role in endoproteolysis of APP, BACE1 participates in the proteolytic processing of neuregulin 1 (NRG1) and influences the myelination of central and peripheral axons. Although NRG1 has been genetically linked to schizophrenia and NRG1(+/-) mice exhibit a number of schizophrenia-like behavioral traits, it is not known whether altered BACE1-dependent NRG1 signaling can cause similar behavioral abnormalities. To test this hypothesis, we analyze the behaviors considered to be rodent analogs of clinical features of schizophrenia in BACE1(-/-) mice with impaired processing of NRG1. We demonstrate that BACE1(-/-) mice exhibit deficits in prepulse inhibition, novelty-induced hyperactivity, hypersensitivity to a glutamatergic psychostimulant (MK-801), cognitive impairments, and deficits in social recognition. Importantly, some of these manifestations were responsive to treatment with clozapine, an atypical antipsychotic drug. Moreover, although the total amount of ErbB4, a receptor for NRG1 was not changed, binding of ErbB4 with postsynaptic density protein 95 (PSD95) was significantly reduced in the brains of BACE1(-/-) mice. Consistent with the role of ErbB4 in spine morphology and synaptic function, BACE1(-/-) mice displayed reduced spine density in hippocampal pyramidal neurons. Collectively, our findings suggest that alterations in BACE1-dependent NRG1/ErbB4 signaling may participate in the pathogenesis of schizophrenia and related psychiatric disorders.

Integrity signals

Registry

Crossref · 10.1073/pnas.0710373105

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
Cai, H., Wang, Y., McCarthy, D. B., Wen, H., Borchelt, D., Price, D. L., & Wong, P. C. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 1,087
Self-citation
Neuregulins: functions, forms, and signaling strategies
Falls, D. L. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00102-7 · Cited by 1,071
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L. W., Lai, C., Schwab, M. H., & Nave, K. (2004) · Science · doi:10.1126/science.1095862 · Cited by 940
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917
Neurobiology of Schizophrenia
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 719
Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C. (2006) · Science · doi:10.1126/science.1132341 · Cited by 703
Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659
Integrative Properties of Radial Oblique Dendrites in Hippocampal CA1 Pyramidal Neurons
Losonczy, A., & Magee, J. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.016 · Cited by 641
Bace1 modulates myelination in the central and peripheral nervous system
Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience · doi:10.1038/nn1797 · Cited by 608
Self-citation

Show all 39 references

Sorted by citations

Items 101–200 of 291

Cdk5 Protein Inhibition and Aβ42 Increase BACE1 Protein Level in Primary Neurons by a Post-transcriptional Mechanism
Sadleir, K. R., & Vassar, R. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333914 · Cited by 59
Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease
Egorova, P. A., Александровна, П. Е., & Борисович, Б. И. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.03.010 · Cited by 60
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
Funamoto, S., Sasaki, T., Ishihara, S., Nobuhara, M., Nakano, M., Watanabe‐Takahashi, M., Saito, T., Kakuda, N., Miyasaka, T., Nishikawa, K., et al. (2013) · Nature Communications · doi:10.1038/ncomms3529 · Cited by 60
Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity
Wang, H., Megill, A., He, K., Kirkwood, A., & Lee, H. (2012) · Neural Plasticity · doi:10.1155/2012/272374 · Cited by 66
Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System
Shyam, R., Ren, Y., Lee, J., Braunstein, K. E., Mao, H.-Q., & Wong, P. C. (2015) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2015.15 · Cited by 58
Self-citation
Neuregulin-1 signalling and antipsychotic treatment
Deng, C., Pan, B., Engel, M., & Huang, X. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3003-2 · Cited by 59
Genetics and Smoking
Loukola, A., Hällfors, J., Korhonen, T., & Kaprio, J. A. (2014) · Current Addiction Reports · doi:10.1007/s40429-013-0006-3 · Cited by 61
RETRACTED: Gene regulation by antisense transcription: A focus on neurological and cancer diseases
Najafi, S., Tan, S. C., Raee, P., Rahmati, Y., Asemani, Y., Lee, E. H. C., Hushmandi, K., Zarrabi, A., Aref, A. R., Ashrafizadeh, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112265 · Cited by 56
Retracted
Mice mutant for genes associated with schizophrenia: Common phenotype or distinct endophenotypes?
Desbonnet, L., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.001 · Cited by 57
Expression of ErbB4 in the neurons of Alzheimer's disease brain and APP/PS1 mice, a model of Alzheimer's disease
Woo, R., Lee, J.-H., Yu, H.-N., Song, D., & Baik, T. (2011) · Anatomy & Cell Biology · doi:10.5115/acb.2011.44.2.116 · Cited by 57
Differential Neuregulin 1 Cleavage in the Prefrontal Cortex and Hippocampus in Schizophrenia and Bipolar Disorder: Preliminary Findings
Marballi, K. K., Cruz, D. A., Thompson, P., & Walss‐Bass, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036431 · Cited by 58
Functions of the Alzheimer’s Disease Protease BACE1 at the Synapse in the Central Nervous System
Munro, K. M., Nash, A., Pigoni, M., Lichtenthaler, S. F., & Gunnersen, J. M. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0800-1 · Cited by 59
BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus
Kang, E. L., Biscaro, B., Piazza, F., & Tesco, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407072 · Cited by 55
The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1
Kandalepas, P. C., & Vassar, R. J. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140604122059 · Cited by 56
Allele-specific RNAi Mitigates Phenotypic Progression in a Transgenic Model of Alzheimer's Disease
Rodríguez-Lebrón, E., Gouvion, C. M., Moore, S. A., Davidson, B. L., & Paulson, H. L. (2009) · Molecular Therapy · doi:10.1038/mt.2009.123 · Cited by 54
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin
Prox, J., Rittger, A., & Säftig, P. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2952-0 · Cited by 60
Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease
Moussa, C. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1369527 · Cited by 55
Reversible Overexpression of Bace1-Cleaved Neuregulin-1 N-Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice
Luo, X., He, W., Hu, X., & Yan, R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.026 · Cited by 54
Neurological dysfunctions associated with altered BACE 1‐dependent Neuregulin‐1 signaling
Hu, X., Fan, Q., Hou, H., & Yan, R. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13395 · Cited by 54
Proteolytic processing of Neuregulin-1
Willem, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.003 · Cited by 52
Neural functions of bisecting GlcNAc
Kizuka, Y., & Taniguchi, N. (2018) · Glycoconjugate Journal · doi:10.1007/s10719-018-9829-4 · Cited by 50
Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function
Zhu, K., Peters, F., Filser, S., & Herms, J. W. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.022 · Cited by 52
Modeling an Anti-Amyloid Combination Therapy for Alzheimer’s Disease
Chow, V. W., Savonenko, A. V., Melnikova, T., Kim, H., Price, D. L., Li, T., & Wong, P. C. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000337 · Cited by 53
Self-citation
Alzheimer's Therapeutics: Translation of Preclinical Science to Clinical Drug Development
Savonenko, A. V., Melnikova, T., Hiatt, A., Li, T., Worley, P. F., Troncoso, J. C., Wong, P. C., & Price, D. L. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.211 · Cited by 52
Self-citation
Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases
Fleck, D., Voß, M., Brankatschk, B., Giudici, C., Hampel, H., Schwenk, B. M., Edbauer, D., Fukumori, A., Steiner, H., Kremmer, E., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.697995 · Cited by 52
Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies
Ohno, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.007 · Cited by 51
BACE1 controls synaptic function through modulating release of synaptic vesicles
Das, B., Singh, N., Yao, A. Y., Zhou, J., He, W., Hu, X., & Yan, R. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01166-2 · Cited by 49
Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1*
Zhou, L., Chávez-Gutiérrez, L., Bockstael, K., Sannerud, R., Annaert, W., May, P., Karran, E., & de Strooper, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.194860 · Cited by 52
Future Therapeutics in Alzheimer’s Disease: Development Status of BACE Inhibitors
Evin, G. M. (2016) · BioDrugs · doi:10.1007/s40259-016-0168-3 · Cited by 52
Psychiatric Disorders in Toxoplasma Seropositive Patients--The CD8 Connection
Bhadra, R., Cobb, D., Weiss, L. M., & Khan, I. A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt006 · Cited by 47
Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and alzheimer’s disease
Jafari, Z., Kolb, B. E., & Mohajerani, M. H. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101028 · Cited by 43
Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex
Ohtake, N., Saito, M., Eto, M., & Seki, K. (2014) · Regulatory Peptides · doi:10.1016/j.regpep.2014.04.003 · Cited by 46
Cognitive Impairment in Schizophrenia: a Review of Developmental and Genetic Models, and Pro-cognitive Profile of the Optimised D3 > D2 Antagonist, S33138
Millan, M. J., & Brocco, M. (2008) · Therapies · doi:10.2515/therapie:2008041 · Cited by 44
Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
Hatzimanolis, A., McGrath, J. A., Wang, R., Li, T., Wong, P. C., Nestadt, G., Wolyniec, P. S., Valle, D. L., Pulver, A. E., & Avramopoulos, D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.33 · Cited by 45
Self-citation
β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins
He, W., Hu, J., Xia, Y., & Yan, R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579862 · Cited by 41
Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat
Fielden, M. R., Werner, J. A., Jamison, J. A., Coppi, A., Hickman, D., Dunn, R. T., Trueblood, E. S., Zhou, L., Afshari, C. A., & Lightfoot-Dunn, R. M. (2014) · Toxicologic Pathology · doi:10.1177/0192623314553804 · Cited by 41
Biological Evaluation and Docking Analysis of Potent BACE1 Inhibitors from Boesenbergia rotunda
Youn, K., & Jun, M. (2019) · Nutrients · doi:10.3390/nu11030662 · Cited by 42
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions
Klaver, D. W., Wilce, M. C. J., Cui, H., Hung, A. C., Gasperini, R., Foa, L. C., & Small, D. H. (2010) · Biological Chemistry · doi:10.1515/bc.2010.089 · Cited by 41
Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome
Herber, J., Njavro, J. R., Feederle, R., Schepers, U., Müller, U., Bräse, S., Müller, S. A., & Lichtenthaler, S. F. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000608 · Cited by 40
Examination of BDNF Treatment on BACE1 Activity and Acute Exercise on Brain BDNF Signaling
Baranowski, B. J., Hayward, G. C., Marko, D. M., & MacPherson, R. E. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.665867 · Cited by 41
Alzheimer's CSF markers in older schizophrenia patients
Frisoni, G. B., Prestia, A., Geroldi, C., Adorni, A., Ghidoni, R., Amicucci, G., Bonetti, M., Soricelli, A., Rasser, P. E., Thompson, P. M., et al. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2575 · Cited by 42
Genetic Approaches to Modeling Anxiety in Animals
Jacobson, L. H., & Cryan, J. F. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_31 · Cited by 40
Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models
Kvajo, M., McKellar, H., & Gogos, J. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.051 · Cited by 40
Antipsychotic treatment and neuregulin 1–ErbB4 signalling in schizophrenia
Pan, B., Huang, X., & Deng, C. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.04.002 · Cited by 39
Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer’s disease
Devi, L., & Ohno, M. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.59 · Cited by 38
Consolidation of object recognition memory requires HRI kinase‐dependent phosphorylation of eIF2α in the hippocampus
ILL‐Raga, G., Köhler, C. A., Radiske, A., Lima, R. H., Rosen, M. D., Muñoz, F. J., & Cammarota, M. (2013) · Hippocampus · doi:10.1002/hipo.22113 · Cited by 37
BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines
Blume, T., Filser, S., Jaworska, A. M., Blain, J., Koenig, G., Moschke, K., Lichtenthaler, S. F., & Herms, J. W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00229 · Cited by 37
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR Signaling Pathways in the Antipsychotic Effects of Aripiprazole and Sertindole in Ketamine-Induced Schizophrenia-Like Behaviors in Rats
Nawwar, D. A., Zaki, H. F., & Sayed, R. H. (2021) · Inflammopharmacology · doi:10.1007/s10787-022-01031-w · Cited by 40
Celecoxib and omega-3 fatty acids alone and in combination with risperidone affect the behavior and brain biochemistry in amphetamine-induced model of schizophrenia
El‐Sisi, A. E., Sokar, S. S., El‐Sayad, M. E., Ramadan, E. S., & Osman, E. Y. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.05.024 · Cited by 35
A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles
Fleming, M. S., Li, J. J., Ramos, D., Li, T., Talmage, D. A., Abé, S., Arber, S., & Luo, W. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2160-16.2016 · Cited by 35
Advancing a functional genomics for schizophrenia: Psychopathological and cognitive phenotypes in mutants with gene disruption
Kirby, B. P., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.010 · Cited by 36
BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease
Bi, D., Bao, H., Yang, X., Wu, Z., Yang, X., Xu, G., Liu, X., Wan, Z., Liu, J., He, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.030 · Cited by 32
Neuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor
Woo, R., Lee, J. H., Kim, H. J., Baek, C.-H., Song, D., Suh, Y.-H., & Baik, T. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.026 · Cited by 33
The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1
Pellegatta, M., & Taveggia, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00093 · Cited by 30
The effects of α‐secretase ADAM10 on the proteolysis of neuregulin‐1
Freese, C., Garratt, A. N., Fahrenholz, F., & Endres, K. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06889.x · Cited by 31
Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1)
Giusti‐Rodríguez, P., Gao, J., Gräff, J., Rei, D., Soda, T., & Tsai, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3588-11.2011 · Cited by 32
Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy
Wu, H., Lu, M., Wang, W., Zhang, M., Zhu, Q.-Q., Xia, Y., Xu, R., Yang, Y., Chen, L., & Ma, Q. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143162 · Cited by 31
Levels of [3H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1
Dean, B., Soulby, A., Evin, G. M., & Scarr, E. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.08.003 · Cited by 30
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia
Onouchi, T., Kobayashi, K., Sakai, K., Shimomura, A., Smits, R., Sumi‐Ichinose, C., Kurosumi, M., Takao, K., Nomura, R., Iizuka‐Kogo, A., et al. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-21 · Cited by 30
Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders
Hayes, L. N., Shevelkin, A. V., Zeledón, M., Steel, G., Chen, P., Obie, C., Pulver, A. E., Avramopoulos, D., Valle, D. L., Sawa, A., et al. (2016) · Complex Psychiatry · doi:10.1159/000445836 · Cited by 31
BACE1 partial deletion induces synaptic plasticity deficit in adult mice
Lombardo, S., Chiacchiaretta, M., Tarr, A. J., Kim, W., Cao, T., Sigal, G., Rosahl, T. W., Xia, W., Haydon, P. G., Kennedy, M. E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56329-7 · Cited by 30
Neuregulin 3 and its roles in schizophrenia risk and presentation
Avramopoulos, D. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32552 · Cited by 33
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing
Rabe, S., Reichwald, J., Ammaturo, D., Strooper, B. D., Säftig, P., Neumann, U., & Staufenbiel, M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07412.x · Cited by 28
Mossy Fiber Long-Term Potentiation Deficits in BACE1 Knock-Outs Can Be Rescued by Activation of α7 Nicotinic Acetylcholine Receptors
Wang, H., Song, L., Lee, A., Laird, F. M., Wong, P. C., & Lee, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1070-10.2010 · Cited by 28
Self-citation
BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia
Zhang, Z., Huang, J., Shen, Y., & Li, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00302 · Cited by 23
Postsynaptic Target Specific Synaptic Dysfunctions in the CA3 Area of BACE1 Knockout Mice
Wang, H., Megill, A., Wong, P. C., Kirkwood, A., & Lee, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092279 · Cited by 29
Self-citation
Complementary roles of the neuron‐enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking
Muthusamy, N., Chen, Y., Yin, D., Mei, L., & Bergson, C. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12989 · Cited by 26
The Glucose Metabolic Pathway as A Potential Target for Therapeutics: Crucial Role of Glycosylation in Alzheimer’s Disease
Bukke, V. N., Villani, R., Moola, A., Wawrzyniak, A., Balawender, K., Orkisz, S., Ferraro, L., Serviddio, G., & Cassano, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207739 · Cited by 27
Alzheimer's secretases regulate voltage-gated sodium channels
Kovacs, D. M., Gersbacher, M. T., & Kim, D. Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.048 · Cited by 27
Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease
Melnikova, T., Park, D., Becker, L. K., Lee, D., Cho, E., Sayyida, N., Tian, J., Bandeen‐Roche, K., Borchelt, D., & Savonenko, A. V. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.08.009 · Cited by 28
Self-citation
Amyloid Beta Hypothesis in Alzheimer's Disease: Major Culprits and Recent Therapeutic Strategies
Dileep, K. V., & Chandra, R. (2019) · Current Drug Targets · doi:10.2174/1389450120666190806153206 · Cited by 26
Sub-chronic Antipsychotic Drug Administration Reverses the Expression of Neuregulin 1 and ErbB4 in a Cultured MK801-Induced Mouse Primary Hippocampal Neuron or a Neurodevelopmental Schizophrenia Model
Li, C., Tang, Y., Yang, J., Zhang, X., Liu, Y., & Tang, A. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1917-x · Cited by 27
β‐Secretase cleavage is not required for generation of the intracellular C‐terminal domain of the amyloid precursor family of proteins
Frigerio, C. S., Fadeeva, J. V., Minogue, A. M., Citron, M., LEUVEN, F. V., Staufenbiel, M., Paganetti, P., Selkoe, D. J., & Walsh, D. M. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07579.x · Cited by 25
Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior
Dries, D. R., Zhu, Y., Brooks, M., Forero, D. A., Adachi, M., Cenik, B., West, J. M., Han, Y., Yu, C., Arbella, J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.715078 · Cited by 28
Pharmacotherapy of cognition in schizophrenia
Meltzer, H. Y. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.04.009 · Cited by 25
Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia
Barakat, A., Dean, B., Scarr, E., & Evin, G. M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.09.001 · Cited by 26
The Pursuit of the “Inside” of the Amyloid Hypothesis—Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?
Takasugi, N., Komai, M., Kaneshiro, N., Ikeda, A., Kamikubo, Y., & Uehara, T. (2023) · Cells · doi:10.3390/cells12030454 · Cited by 29
The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease
Ghosh, A. K., Cárdenas, E. L., & Osswald, H. L. (2016) · Topics in medicinal chemistry · doi:10.1007/7355_2016_16 · Cited by 23
Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia
Li, C., Tao, H., Yang, X., Zhang, X., Liu, Y., Tang, Y., & Tang, A. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.24346 · Cited by 23
White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia
Xu, H., & Li, X. (2011) · Schizophrenia Research and Treatment · doi:10.1155/2011/826976 · Cited by 23
ΔFosB Induction in Prefrontal Cortex by Antipsychotic Drugs is Associated with Negative Behavioral Outcomes
Dietz, D., Kennedy, P., Sun, H., Maze, I. S., Gancarz, A. M., Vialou, V., Koo, J. W., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.255 · Cited by 21
Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats
Takahashi, H., Fukumoto, H., Maeda, R., Terauchi, J., Kato, K., & Miyamoto, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.032 · Cited by 21
β-Secretase BACE1 Is Required for Normal Cochlear Function
Dierich, M., Hartmann, S., Dietrich, N., Moeser, P., Brede, F. A., Chacko, L. J., Tziridis, K., Schilling, A., Krauß, P., Hessler, S., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0028-19.2019 · Cited by 21
BACE Inhibitor Clinical Trials for Alzheimer’s Disease
Watkins, E. A., & Vassar, R. J. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231258 · Cited by 23
Cellular basis of Alzheimer′s disease
Rajendran, L., Bali, J., Halima, S. B., Felmy, B., Goodger, Z. V., & Zurbriggen, S. (2010) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.74251 · Cited by 20
Mental Illness and Amyloid: A Scoping Review of Scientific Evidence over the Last 10 Years (2011 to 2021)
Pandolfo, G., Iannuzzo, F., Genovese, G., Bruno, A., Pioggia, G., Baldari, S., & Gangemi, S. (2021) · Brain Sciences · doi:10.3390/brainsci11101352 · Cited by 18
Amyloid‐β in Alzheimer's disease: Structure, toxicity, distribution, treatment, and prospects
Yu, Y., Yu, S., Battaglia, G., & Tian, X. (2024) · Ibrain · doi:10.1002/ibra.12155 · Cited by 19
Reversing hypomyelination in BACE1‐null mice with Akt‐DD overexpression
Hu, X., Schlanger, R., He, W., Macklin, W. B., & Yan, R. (2013) · The FASEB Journal · doi:10.1096/fj.12-224212 · Cited by 19
Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome
Lin, R., Learman, L. N., Bangash, M. A., Melnikova, T., Leyder, E. C., Reddy, S. C., Naidoo, N. N., Park, J. M., Savonenko, A. V., & Worley, P. F. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110014 · Cited by 18
Self-citation
Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
Kaneshiro, N., Komai, M., Imaoka, R., Ikeda, A., Kamikubo, Y., Saito, T., Saido, T. C., Tomita, T., Hashimoto, T., Iwatsubo, T., et al. (2022) · iScience · doi:10.1016/j.isci.2022.103869 · Cited by 16
Peptide p3 may play a neuroprotective role in the brain
Han, W., Ji, T., Mei, B., & Su, J. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2010.12.013 · Cited by 17
Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells
Kamikubo, Y., Takasugi, N., Niisato, K., Hashimoto, Y., & Sakurai, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160806 · Cited by 17
Nrg1 haploinsufficiency alters inhibitory cortical circuits
Navarro-González, C., Carceller, H., Benito, M., Serra, I., Navarrete, M., Domínguez-Canterla, Y., Rodríguez-Prieto, Á., González-Manteiga, A., & Fazzari, P. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105442 · Cited by 16
Alzheimer Disease
Savonenko, A. V., Melnikova, T., Li, T., Price, D. L., & Wong, P. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398270-4.00021-5 · Cited by 20
Self-citation
Beta secretase activity in peripheral nerve regeneration
Farah, M. H., & Tallon, C. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217319 · Cited by 16
Penetrating Ballistic-Like Brain Injury Leads to MicroRNA Dysregulation, BACE1 Upregulation, and Amyloid Precursor Protein Loss in Lesioned Rat Brain Tissues
Thangavelu, B., Wilfred, B. R., Johnson, D., Gilsdorf, J. S., Shear, D. A., & Boutté, A. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00915 · Cited by 16
BACE1-Deficient Mice Exhibit Alterations in Immune System Pathways
Stertz, L., Contreras‐Shannon, V., Monroy‐Jaramillo, N., Sun, J., & Walss‐Bass, C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0341-1 · Cited by 15
Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia
Zhang, Z., Li, Y., He, F., Cui, Y., Zheng, Y., & Li, R. (2020) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2020.152176 · Cited by 15
Molecular Genetic Models Related to Schizophrenia and Psychotic Illness: Heuristics and Challenges
O’Tuathaigh, C. M. P., Desbonnet, L., Moran, P. M., Kirby, B. P., & Waddington, J. L. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_111 · Cited by 13
BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
Weber, M., Wu, T. Z., Meilandt, W. J., Domínguez, S. L., Solanoy, H. O., Maloney, J. A., Ngu, H., Baca, M., Kung, C., Lima, L. M., et al. (2017) · Scientific Reports · doi:10.1038/srep44249 · Cited by 14

Authors: Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., & Wong, P. C.
Affiliations: Johns Hopkins University (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Wong, P. C.
ORCID: Savonenko, A. V.
Wong, P. C.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-04-08
Volume: 105
Issue: 14
Pages: 5585-5590
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0710373105
PMC: PMC2291091
OpenAlex: W2063978545
Cited by: 290
References: 39
Citations by year: 2026: 8 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 6 · 2019: 12 · 2018: 10 · 2017: 16 · 2016: 27 · 2015: 24 · 2014: 23 · 2013: 20 · 2012: 24
FWCI: 21.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
Bristol-Myers Squibb Foundation
Bristol-Myers Squibb
National Institutes of Health
National Institute on Aging (P50AG005146, P50AG05146)
National Institute of Neurological Disorders and Stroke (R01 NS41438, P01NS047308, R01NS041438)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: BACE1, neuregulin-1, ERBB4 signaling, schizophrenia, prepulse inhibition, cognitive impairment, social recognition, clozapine, PSD-95, dendritic spine density, hippocampal pyramidal neurons, synaptic function
MeSH terms: Animals, Behavior, Animal, Hippocampus, Schizophrenia, Signal Transduction, Aspartic Acid Endopeptidases, Mice, Knockout, Neuregulin-1, Mice, Amyloid Precursor Protein Secretases, ErbB Receptors, Receptor, ErbB-4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1 -null mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks