Wong, Philip C.

Amyloid Precursor Protein Processing and Alzheimer's Disease

O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 2,061

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

Freibaum, B. D., Lu, Y., Lopez-Gonzalez, R., Kim, N. C., Almeida, S., Lee, K.-H., Badders, N., Valentine, M., Miller, B. L., Wong, P. C., et al. (2015) · Nature

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 841

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 729

An overview of APP processing enzymes and products.

Chow, V. W., Mattson, M. P., Wong, P. C., & Gleichmann, M. (2010) · NeuroMolecular Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 684

Bace1 modulates myelination in the central and peripheral nervous system

Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 608

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C. (2009) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 577

BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 521

Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

Vetrivel, K. S., Cheng, H., Lin, W., Sakurai, T., Li, T., Nukina, N., Wong, P. C., Xu, H., & Thinakaran, G. (2004) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsLipid Membrane Structure and Behavior

Cited by 413

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., et al. (1998) · Neuron

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 355

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1 -null mice

Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., & Wong, P. C. (2008) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentAlzheimer's disease research and treatments

Cited by 290

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

Hu, X., Zhou, X., He, W., Yang, J., Xiong, W., Wong, P., Wilson, C. G., & Yan, R. (2010) · Journal of Neuroscience

Alzheimer's disease research and treatmentsEpilepsy research and treatment

Cited by 162

Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

Vetrivel, K. S., Meckler, X., Chen, Y., Nguyen, P. D., Seidah, N. G., Vassar, R., Wong, P. C., Fukata, M., Kounnas, M. Z., & Thinakaran, G. (2009) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsLipid Membrane Structure and Behavior

Cited by 153

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

Li, T., Braunstein, K. E., Zhang, J., Lau, A., Sibener, L., Deeble, C., & Wong, P. C. (2016) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 114

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

LaClair, K. D., Manaye, K. F., Lee, D. L., Allard, J. S., Savonenko, A. V., Troncoso, J. C., & Wong, P. C. (2013) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 83

Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System

Shyam, R., Ren, Y., Lee, J., Braunstein, K. E., Mao, H.-Q., & Wong, P. C. (2015) · Molecular Therapy - Nucleic Acids

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 58

An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks

Bedont, J. L., LeGates, T. A., Buhr, E., Bathini, A., Ling, J. P., Bell, B., Wu, M. N., Wong, P. C., Van Gelder, R. N., Mongrain, V., et al. (2017) · Current Biology

Circadian rhythm and melatoninSleep and Wakefulness Research

Cited by 41

Elevated nuclear TDP-43 induces constitutive exon skipping

Carmen-Orozco, R. P., Tsao, W., Ye, Y., Sinha, I. R., Chang, K., Trinh, V., Chung, W., Bowden, K., Troncoso, J. C., Blackshaw, S., et al. (2023) · Molecular Neurodegeneration

Amyotrophic Lateral Sclerosis ResearchRNA Research and Splicing

Cited by 27

Elevated nuclear TDP-43 induces constitutive exon skipping

Carmen-Orozco, R. P., Tsao, W., Ye, Y., Sinha, I. R., Chang, K., Trinh, V. T., Chung, W., Bowden, K., Troncoso, J. C., Blackshaw, S., et al. (2024) · Molecular Neurodegeneration

Amyotrophic Lateral Sclerosis ResearchRNA Research and Splicing

Cited by 27

Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis

Kumar, S., Song, K., Wang, J., Baghel, M. S., Zeng, Y., Shen, K., Zheng, J., Crane, J., Demehri, S., Gao, P., et al. (2025) · Nature Aging

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 16