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Cited by 1,021Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchAdvanced Neuroimaging Techniques and Applications

Large-scale model of mammalian thalamocortical systems

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Izhikevich, Eugene M., Edelman, Gerald M.·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0712231105PMC PMC2265160
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Abstract

The understanding of the structural and dynamic complexity of mammalian brains is greatly facilitated by computer simulations. We present here a detailed large-scale thalamocortical model based on experimental measures in several mammalian species. The model spans three anatomical scales. ( i ) It is based on global (white-matter) thalamocortical anatomy obtained by means of diffusion tensor imaging (DTI) of a human brain. ( ii ) It includes multiple thalamic nuclei and six-layered cortical microcircuitry based on in vitro labeling and three-dimensional reconstruction of single neurons of cat visual cortex. ( iii ) It has 22 basic types of neurons with appropriate laminar distribution of their branching dendritic trees. The model simulates one million multicompartmental spiking neurons calibrated to reproduce known types of responses recorded in vitro in rats. It has almost half a billion synapses with appropriate receptor kinetics, short-term plasticity, and long-term dendritic spike-timing-dependent synaptic plasticity (dendritic STDP). The model exhibits behavioral regimes of normal brain activity that were not explicitly built-in but emerged spontaneously as the result of interactions among anatomical and dynamic processes. We describe spontaneous activity, sensitivity to changes in individual neurons, emergence of waves and rhythms, and functional connectivity on different scales.

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  • Adaptive resonance can account for binding among visual feature maps, a basic property of visual perception.

    “Adaptive resonance has many useful properties, as shown in modeling studies like the Darwin autonomous robot series, where it can account for binding among visual feature maps, a basic property of visual perception (Figure 2) (Izhikevich and Edelman, 2008).”

    From Global Workspace Dynamics: Cortical “Binding and Propagation” Enables Conscious Contents (2013) · cites this paper as Izhikevich and Edelman, 2008

    The Abstract describes a large-scale thalamocortical simulation, and the Discussion describes its spontaneous rhythms, propagating waves, and functional connectivity. Searches for adaptive resonance, the Darwin autonomous robot series, and binding among visual feature maps found no passage in our copy addressing the attributed claim. (LLM, conf=0.76)

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  • Spatiotopic activity maps can bind into coherent gestalts using adaptive resonance (reentry).

    “Spatiotopic activity maps can bind into coherent gestalts using adaptive resonance (reentry).”

    From Global Workspace Dynamics: Cortical “Binding and Propagation” Enables Conscious Contents (2013) · cites this paper as Izhikevich and Edelman, 2008

    The Discussion (page not provided) reports spontaneous rhythms, propagating waves, and anticorrelated functional clusters, but does not say that spatiotopic maps bind into gestalts. Searches for spatiotopic maps, binding, adaptive resonance, and reentry found no passage addressing that mechanism. (LLM, conf=0.74)

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Authors
Izhikevich, E. M., & Edelman, G. M.
Affiliations
Neurosciences Institute (US)
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2008-03-04
Volume
105
Issue
9
Pages
3593-3598
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0712231105
PMC
PMC2265160
OpenAlex
W2152502378
Cited by
1,021
References
4
Citations by year
2026: 18 · 2025: 28 · 2024: 40 · 2023: 58 · 2022: 44 · 2021: 44 · 2020: 45 · 2019: 54 · 2018: 70 · 2017: 67 · 2016: 53 · 2015: 55 · 2014: 66 · 2013: 88 · 2012: 85
FWCI
35.60
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Max Planck School of Photonics
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
thalamocortical system, large-scale neural models, short-term plasticity, diffusion tensor imaging, thalamic nuclei, cat visual cortex, spontaneous brain activity, neural oscillations, functional connectivity, receptor kinetics
MeSH terms
Action Potentials, Animals, Brain, Cats, Cerebral Cortex, Computer Simulation, Humans, Mammals, Models, Biological, Models, Neurological, Neurons, Synapses, Thalamic Nuclei, Visual Cortex

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