Cited by 303Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Adult neurogenesis: integrating theories and separating functions

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Aimone, James B., Deng, Wei, Gage, Fred H.·2010·Trends in Cognitive Sciences

Abstract

The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.

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Crossref · 10.1016/j.tics.2010.04.003

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  • In vivo detectability of neurogenesis in humans has been difficult, and due to impaired comparability between species, opinions on its functional relevance in humans diverge.

    “In vivo detectability of neurogenesis in humans has been difficult and due to impaired comparability between species, opinions on the functional relevance in humans diverge (Aimone et al., 2010;Powers, 2013).”

    From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Aimone et al., 2010

    The Conclusions and Future Directions section says that quantifying and tracking new neurons in humans remain significant challenges and that tracing methods used in animals are not applicable to human studies. It also calls the extent of new-neuron integration into the human brain controversial. It does not say that poor comparability between species causes divergent opinions about neurogenesis’s functional relevance in humans; no page number is available in our copy. (LLM, conf=0.82)

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  1. [109]Hasselmo ME 1996 Encoding and retrieval of episodic memories: role of cholinergic and GABAergic modulation in the hippocampus Hippocampus 6 693 708 9034856

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Authors
Aimone, J. B., Deng, W., & Gage, F. H.
Affiliations
Salk Institute for Biological Studies (US)
Corresponding author
Gage, Fred H.
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2010-07
Volume
14
Issue
7
Pages
325-337
ISSN
1364-6613 (ISSN-L)
OpenAlex
W1974225650
Cited by
303
References
133
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 25 · 2016: 31 · 2015: 29 · 2014: 46 · 2013: 27 · 2012: 28
FWCI
2.79
Type
journal article
Language
en
Open access
Locations
  • Trends in Cognitive Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH090258, MH090258)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult neurogenesis, dentate gyrus, hippocampus, pattern separation, pattern integration, computational model, granule cells, learning and memory, environmental experience
MeSH terms
Adult, Animals, Hippocampus, Humans, Models, Biological, Neurons, Cell Proliferation, Adult Stem Cells, Neurogenesis

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