Adult neurogenesis: integrating theories and separating functions
Open accessAbstract
The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.
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In vivo detectability of neurogenesis in humans has been difficult, and due to impaired comparability between species, opinions on its functional relevance in humans diverge.
“In vivo detectability of neurogenesis in humans has been difficult and due to impaired comparability between species, opinions on the functional relevance in humans diverge (Aimone et al., 2010;Powers, 2013).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Aimone et al., 2010
The Conclusions and Future Directions section says that quantifying and tracking new neurons in humans remain significant challenges and that tracing methods used in animals are not applicable to human studies. It also calls the extent of new-neuron integration into the human brain controversial. It does not say that poor comparability between species causes divergent opinions about neurogenesis’s functional relevance in humans; no page number is available in our copy. (LLM, conf=0.82)
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- Authors
- Aimone, J. B., Deng, W., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Gage, Fred H.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 14
- Issue
- 7
- Pages
- 325-337
- ISSN
- 1364-6613 (ISSN-L)
- PMC
- PMC2904863
- OpenAlex
- W1974225650
- Cited by
- 303
- References
- 133
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 25 · 2016: 31 · 2015: 29 · 2014: 46 · 2013: 27 · 2012: 28
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cognitive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH090258, MH090258)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus, hippocampus, pattern separation, pattern integration, computational model, granule cells, learning and memory, environmental experience
- MeSH terms
- Adult, Animals, Hippocampus, Humans, Models, Biological, Neurons, Cell Proliferation, Adult Stem Cells, Neurogenesis
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