The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Suppression of non-small cell lung tumor development by the let-7 microRNA family
Open accessAbstract
Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis, such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has been proposed to function in tumor suppression, because reduced expression of let-7 family members is common in non-small cell lung cancer (NSCLC). Here, we show that let-7 functionally inhibits non-small cell tumor development. Ectopic expression of let-7g in K-Ras G12D -expressing murine lung cancer cells induced both cell cycle arrest and cell death. In tumor xenografts, we observed significant growth reduction of both murine and human non-small cell lung tumors when overexpression of let-7g was induced from lentiviral vectors. In let-7g expressing tumors, reductions in Ras family and HMGA2 protein levels were detected. Importantly, let-7g-mediated tumor suppression was more potent in lung cancer cell lines harboring oncogenic K-Ras mutations than in lines with other mutations. Ectopic expression of K-Ras G12D largely rescued let-7g mediated tumor suppression, whereas ectopic expression of HMGA2 was less effective. Finally, in an autochthonous model of NSCLC in the mouse, let-7g expression substantially reduced lung tumor burden.
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Self-citationControl of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
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Metadata
- Authors
- Kumar, M. S., Erkeland, S. J., Pester, R. E., Chen, C. Y., Ebert, M. S., Sharp, P. A., & Jacks, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-03-11
- Volume
- 105
- Issue
- 10
- Pages
- 3903-3908
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137649483
- Cited by
- 843
- References
- 6
- FWCI
- 24.66
- Type
- journal article
- Language
- en
- Open access
- green
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