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Cited by 287

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Macula densa cell signaling involves ATP release through a maxi anion channel

Open access
Bell, Phillip Darwin, Lapointe, Jean-Yves, Sabirov, Ravshan, Hayashi, Seiji, Peti-Peterdi, Janos, Manabe, Ken-ichi, Kovacs, Gergely, Okada, Yasunobu·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0736323100
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Abstract

Macula densa cells are unique renal biosensor cells that detect changes in luminal NaCl concentration ([NaCl] L ) and transmit signals to the mesangial cell/afferent arteriolar complex. They are the critical link between renal salt and water excretion and glomerular hemodynamics, thus playing a key role in regulation of body fluid volume. Since identification of these cells in the early 1900s, the nature of the signaling process from macula densa cells to the glomerular contractile elements has remained unknown. In patch–clamp studies of macula densa cells, we identified an [NaCl] L -sensitive ATP-permeable large-conductance (380 pS) anion channel. Also, we directly demonstrated the release of ATP (up to 10 μM) at the basolateral membrane of macula densa cells, in a manner dependent on [NaCl] L , by using an ATP bioassay technique. Furthermore, we found that glomerular mesangial cells respond with elevations in cytosolic Ca 2+ concentration to extracellular application of ATP (EC 50 0.8 μM). Importantly, we also found increases in cytosolic Ca 2+ concentration with elevations in [NaCl] L , when fura-2-loaded mesangial cells were placed close to the basolateral membrane of macula densa cells. Thus, cell-to-cell communication between macula densa cells and mesangial cells, which express P2Y 2 receptors, involves the release of ATP from macula densa cells via maxi anion channels at the basolateral membrane. This mechanism may represent a new paradigm in cell-to-cell signal transduction mediated by ATP.

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Metadata

Authors
Bell, P. D., Lapointe, J.-Y., Sabirov, R., Hayashi, S., Peti-Peterdi, J., Manabe, K.-I., Kovacs, G., & Okada, Y.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2003-03-24
Volume
100
Issue
7
Pages
4322-4327
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0736323100
OpenAlex
W2142045542
Cited by
287
References
31
FWCI
12.55
Type
journal article
Language
en
Open access
green

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The paper
Bell, P. D., Lapointe, J.-Y., Sabirov, R., Hayashi, S., Peti-Peterdi, J., Manabe, K.-I., Kovacs, G., & Okada, Y. (2003). Macula densa cell signaling involves ATP release through a maxi anion channel. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0736323100

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