The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The protist, Monosiga brevicollis , has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan
Open accessAbstract
Tyrosine kinase signaling has long been considered a hallmark of intercellular communication, unique to multicellular animals. Our genomic analysis of the unicellular choanoflagellate Monosiga brevicollis discovers a remarkable count of 128 tyrosine kinases, 38 tyrosine phosphatases, and 123 phosphotyrosine (pTyr)-binding SH2 proteins, all higher counts than seen in any metazoan. This elaborate signaling network shows little orthology to metazoan counterparts yet displays many innovations reminiscent of metazoans. These include extracellular domains structurally related to those of metazoan receptor kinases, alternative methods for membrane anchoring and phosphotyrosine interaction in cytoplasmic kinases, and domain combinations that link kinases to small GTPase signaling and transcription. These proteins also display a wealth of combinations of known signaling domains. This uniquely divergent and elaborate signaling network illuminates the early evolution of pTyr signaling, explores innovative ways to traverse the cellular signaling circuitry, and shows extensive convergent evolution, highlighting pervasive constraints on pTyr signaling.
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<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
Protein Tyrosine Phosphatases in the Human Genome
Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., & Mustelin, T. (2004) · Cell · doi:10.1016/j.cell.2004.05.018 · Cited by 1,886
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139
Self-citationEvolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins
King, N., Hittinger, C. T., & Carroll, S. B. (2003) · Science · doi:10.1126/science.1083853 · Cited by 424
A receptor tyrosine kinase from choanoflagellates: Molecular insights into early animal evolution
King, N., & Carroll, S. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261477698 · Cited by 234
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Self-citationTyrosine phosphorylation: thirty years and counting
Hunter, T. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.028 · Cited by 658
The Multiple Origins of Complex Multicellularity
Knoll, A. H. (2011) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.031208.100209 · Cited by 562
The origin of Metazoa: a unicellular perspective
Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332
The Capsaspora genome reveals a complex unicellular prehistory of animals
Suga, H., Chen, Z., de Mendoza, A., Sebé-Pedrós, A., Brown, M. W., Kramer, E., Carr, M., Kerner, P., Vervoort, M., Sánchez-Pons, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms3325 · Cited by 317
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Metadata
- Authors
- Manning, G., Young, S. L., Miller, W. T., & Zhai, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-07-15
- Volume
- 105
- Issue
- 28
- Pages
- 9674-9679
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2030828466
- Cited by
- 209
- References
- 5
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Manning, G., Young, S. L., Miller, W. T., & Zhai, Y. (2008). The protist, Monosiga brevicollis , has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0801314105
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