The Capsaspora genome reveals a complex unicellular prehistory of animals
Open accessAbstract
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filasterean Capsaspora owczarzaki, the closest known unicellular relative of metazoans besides choanoflagellates. Analyses of this genome alter our understanding of the molecular complexity of metazoans’ unicellular ancestors showing that they had a richer repertoire of proteins involved in cell adhesion and transcriptional regulation than previously inferred only with the choanoflagellate genome. Some of these proteins were secondarily lost in choanoflagellates. In contrast, most intercellular signalling systems controlling development evolved later concomitant with the emergence of the first metazoans. We propose that the acquisition of these metazoan-specific developmental systems and the co-option of pre-existing genes drove the evolutionary transition from unicellular protists to metazoans. Unicellular ancestors of metazoans can provide significant insights into the origin of multicellularity. Suga et al. present the first complete genome of the filasterean Capsaspora owczarzakiand suggest an evolutionary mechanism for the transition from unicellular protists to metazoans.
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Most structural components of the post-synaptic density are present in the sponge Amphimedon, and some have homologs in choanoflagellates and other unicellular holozoans.
“most of the structural components of the post-synaptic density (PSD) are present in the sponge Amphimedon [22,28], and some have clear homologs in choanoflagellates and other unicellular holozoans [29,30]”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [29]
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Losing Complexity: The Role of Simplification in Macroevolution
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Self-citationGlycoprotein Hormones and Their Receptors Emerged at the Origin of Metazoans
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The evolution of animal genomes
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Asexual Amoebae Escape Muller's Ratchet through Polyploidy
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Self-citationUnicellular origin of the animal microRNA machinery
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Tracing the evolutionary history of blood cells to the unicellular ancestor of animals
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- Authors
- Suga, H., Chen, Z., de Mendoza, A., Sebé-Pedrós, A., Brown, M. W., Kramer, E., Carr, M., Kerner, P., Vervoort, M., Sánchez-Pons, N., Torruella, G., Derelle, R., Manning, G., Lang, B. F., Russ, C., Haas, B. J., Roger, A. J., Nusbaum, C., & Ruiz-Trillo, I.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Broad Institute (US)
- Dalhousie University (CA)
- Salk Institute for Biological Studies (US)
- University of Huddersfield (GB)
- Centre National de la Recherche Scientifique (FR)
- Centre for Genomic Regulation (ES)
- Université de Montréal (CA)
- ORCID
- Venue
- Nature Communications
- Published
- 2013-08-14
- Volume
- 4
- Issue
- 1
- Pages
- 2325-2325
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC3753549
- OpenAlex
- W2114418309
- Cited by
- 317
- References
- 53
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 26 · 2023: 20 · 2022: 28 · 2021: 17 · 2020: 18 · 2019: 25 · 2018: 20 · 2017: 29 · 2016: 29 · 2015: 36 · 2014: 25 · 2013: 5
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Huddersfield Repository (University of Huddersfield) (acceptedVersion, cc-by-nc-nd)
- RePEc: Research Papers in Economics (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- Huddersfield Research Portal (University of Huddersfield) (submittedVersion, cc-by-nc-nd)
- Funders
- Broad Institute
- Agence Nationale de la Recherche (ANR grant BLAN-0294, BLAN-0294)
- Institució Catalana de Recerca i Estudis Avançats
- Centre National de la Recherche Scientifique
- Institut Universitaire de France
- National Human Genome Research Institute (HG003067-06, HG003067-08, U54HG003067, HG003067-10, HG003067, HG003067-09, HG003067-07, HG003067-05)
- FP7 Ideas: European Research Council (206883)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protist diversity and phylogeny
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Capsaspora owczarzaki, origin of multicellularity, animal evolution, genome sequencing, cell adhesion proteins, transcriptional regulation, intercellular communication, gene co-option, choanoflagellates, Monosiga brevicollis, gene loss
- MeSH terms
- Animals, Base Sequence, Cell Adhesion, Biological Evolution, Mitochondria, Phylogeny, Transcription, Genetic, Signal Transduction, Genome, Apoptosis, Sequence Analysis, DNA, Protein Structure, Tertiary, Evolution, Molecular, Intercellular Signaling Peptides and Proteins, Mesomycetozoea, Choanoflagellata
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