The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
miR-34a repression of SIRT1 regulates apoptosis
Open accessAbstract
MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation is not completely understood. We now show that the microRNA miR-34a regulates silent information regulator 1 (SIRT1) expression. MiR-34a inhibits SIRT1 expression through a miR-34a-binding site within the 3′ UTR of SIRT1. MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. Furthermore, miR-34 suppression of SIRT1 ultimately leads to apoptosis in WT human colon cancer cells but not in human colon cancer cells lacking p53. Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway.
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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
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Self-citation
Cited by
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Mammalian Sirtuins: Biological Insights and Disease Relevance
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Sirtuins as regulators of metabolism and healthspan
Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008
The miR-34 family in cancer and apoptosis
Hermeking, H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236
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Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156
Metadata
- Authors
- Yamakuchi, M., Ferlito, M., & Lowenstein, C. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-09-09
- Volume
- 105
- Issue
- 36
- Pages
- 13421-13426
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006173503
- Cited by
- 1,342
- References
- 12
- FWCI
- 23.85
- Type
- journal article
- Language
- en
- Open access
- green
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