The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
Open accessAbstract
Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the ανβ3-expressing tumor vasculature. We observed real-time targeting of this NP to tumor vessels and noted selective apoptosis in regions of the ανβ3-expressing tumor vasculature. In clinically relevant pancreatic and renal cell orthotopic models of spontaneous metastasis, targeted delivery of Dox produced an antimetastatic effect. In fact, ανβ3-mediated delivery of this drug to the tumor vasculature resulted in a 15-fold increase in antimetastatic activity without producing drug-associated weight loss as observed with systemic administration of the free drug. These findings reveal that NP-based delivery of cytotoxic drugs to the ανβ3-positive tumor vasculature represents an approach for treating metastatic disease.
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Metadata
- Authors
- Murphy, E. A., Majeti, B. K., Barnes, L. A., Makale, M., Weis, S. M., Lutu-Fuga, K., Wrasidlo, W., & Cheresh, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-07-08
- Volume
- 105
- Issue
- 27
- Pages
- 9343-9348
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113676592
- Cited by
- 455
- References
- 30
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- green
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