Stabilization of HIF-1α is critical to improve wound healing in diabetic mice

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600

The global burden of diabetic foot disease

Boulton, A. J. M., Vileikytė, L., Tennvall, G. R., & Apelqvist, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67698-2 · Cited by 2,578

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

Frank, S., Hübner, G., Breier, G., Longaker, M. T., Greenhalgh, D. G., & Werner, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12607 · Cited by 764

Current and promising applications of MOF composites in the healing of diabetes wounds

Deng, L.-E., Qiu, Y., Zeng, Y., Zou, J., Kumar, A., Pan, Y. H., Nezamzadeh‐Ejhieh, A., Liu, J., & Liu, X. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00232f · Cited by 38

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

Rafehi, H., El‐Osta, A., & Karagiannis, T. C. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.05.015 · Cited by 37

Is Diabetic Skeletal Fragility Associated with Microvascular Complications in Bone?

Fajardo, R. J. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0341-8 · Cited by 38

Two-dimensional nanovermiculite and polycaprolactone electrospun fibers composite scaffolds promoting diabetic wound healing

Huang, X., Wang, Q., Mao, R., Wang, Z., Shen, S. G., Mou, J., & Dai, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01556-w · Cited by 38

Antibacterial, Adhesive, and Conductive Hydrogel for Diabetic Wound Healing

Lin, Z., Fan, D., Li, G., He, L., Qin, X., Zhao, B., Wang, Q., & Liang, W. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202200349 · Cited by 37

The Tissue Response to Hypoxia: How Therapeutic Carbon Dioxide Moves the Response toward Homeostasis and Away from Instability

Rivers, R. J., & Meininger, C. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065181 · Cited by 44

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma

Haller, B. K., Bråve, A., Wallgard, E., Roswall, P., Sunkari, V. G., Mattson, U., Hallengärd, D., Catrina, S., Hellström, M., & Pietras, K. (2010) · Oncogene · doi:10.1038/onc.2010.176 · Cited by 36

Hypoxia stimulates collagen hydroxylation in gingival fibroblasts and periodontal ligament cells

Morimoto, C., Takedachi, M., Kawasaki, K., Shimomura, J., Murata, M., Hirai, A., Kawakami, K., Sawada, K., Iwayama, T., & Murakami, S. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0670 · Cited by 36

Polyphenol-driven facile assembly of a nanosized acid fibroblast growth factor-containing coacervate accelerates the healing of diabetic wounds

Tong, M., Lu, C., Huang, L., Yang, J., Yang, S.-T., Chen, H.-B., Xue, P., Luo, L.-Z., Yao, Q., Xu, H., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.11.054 · Cited by 34

Single Intraosseous Injection of Simvastatin Promotes Endothelial Progenitor Cell Mobilization, Neovascularization, and Wound Healing in Diabetic Rats

Liu, C., Zhu, J., Hai, B., Zhang, W., Wang, H., Leng, H., Xu, Y., & Song, C. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000006502 · Cited by 34

Elevated glucose increases genomic instability by inhibiting nucleotide excision repair

Ciminera, A. K., Shuck, S. C., & Termini, J. S. (2021) · Life Science Alliance · doi:10.26508/lsa.202101159 · Cited by 33

Testosterone and Voluntary Exercise Promote Angiogenesis in Hearts of Rats with Diabetes by Enhancing Expression of VEGF-A and SDF-1a

Chodari, L., Mohammadi, M., Ghorbanzadeh, V., Dariushnejad, H., & Mohaddes, G. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.03.004 · Cited by 32

Microfluidic wound bandage: Localized oxygen modulation of collagen maturation

Lo, J. F., Brennan, M., Merchant, Z., Chen, L., Guo, S., Eddington, D., & DiPietro, L. A. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12021 · Cited by 33

Argon Mitigates Impaired Wound Healing Process and Enhances Wound Healing In Vitro and In Vivo

Ning, J., Zhao, H., Chen, B., Mi, E., Yang, Z. L., Qing, W., Lam, K. W. J., Yi, B., Chen, Q., Gu, J., et al. (2019) · Theranostics · doi:10.7150/thno.29361 · Cited by 33

Dimethyloxalylglycine, a small molecule, synergistically increases the homing and angiogenic properties of human mesenchymal stromal cells when cultured as 3D spheroids

Costa, M. H., Serra, J., McDevitt, T. C., Cabral, J. M. S., da Silva, C. L., & Ferreira, F. C. (2021) · Biotechnology Journal · doi:10.1002/biot.202000389 · Cited by 33

In-situ oxygen-supplying ROS nanopurifier for enhanced healing of MRSA-infected diabetic wounds via microenvironment modulation

Wang, Q., Luo, Z., Li, Z., Hu, H., Lin, Y., Fan, X., Li, Z., & Wu, Y. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.044 · Cited by 32

Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling

Qiu, S., Jia, Y., Sun, Y., Han, P., Xu, J., Wen, G., & Chai, Y. (2019) · Journal of Diabetes Research · doi:10.1155/2019/1897174 · Cited by 31

Hypoxia suppresses myofibroblast differentiation by changing RhoA activity

Leinhos, L., Peters, J., Krull, S., Helbig, L., Vogler, M., Levay, M., van Belle, G. J., Ridley, A. J., Lutz, S., Katschinski, D. M., et al. (2019) · Journal of Cell Science · doi:10.1242/jcs.223230 · Cited by 30

Single-cell transcriptomics of human-skin-equivalent organoids

Stabell, A. R., Lee, G. E., Jia, Y., Wong, K. N., Wang, S., Ling, J., Nguyen, S. D., Sen, G. L., Nie, Q., & Atwood, S. X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112511 · Cited by 30

Photosynthetic and Self‐Draining Biohybrid Dressing for Accelerating Healing of Diabetic Wound

Ren, X., Hou, Z., Pang, B., Gao, C., & Tang, R. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302287 · Cited by 30

Dibutyl Phthalate Inhibits the Effects of Follicle-Stimulating Hormone on Rat Granulosa Cells Through Down-Regulation of Follicle-Stimulating Hormone Receptor1

Wang, X.-J., Xiong, G.-P., Luo, X., Huang, S., Liu, J., Huang, X., Xie, Y., & Lin, W. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.136002 · Cited by 30

Bioactive multi-engineered hydrogel offers simultaneous promise against antibiotic resistance and wound damage

Zhang, J., Ge, J., Xu, Y., Chen, J., Zhou, A., Sun, L., Gao, Y., Zhang, Y., Gu, T., & Ning, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.247 · Cited by 30

The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis

Hourigan, S. T., Solly, E. L., Nankivell, V. A., Ridiandries, A., Weimann, B. M., Henriquez, R., Tepper, E. R., Zhang, J. Q. J., Tsatralis, T., Clayton, Z. E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32016-x · Cited by 30

Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities

Al-Taweel, R., Hammad, A. S., Tajammul, A., Crovella, S., & Al‐Asmakh, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311365 · Cited by 35

Role of HIF-1α in maternal hyperglycemia-induced embryonic vasculopathy

Yang, P., & Reece, E. A. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.01.012 · Cited by 29

Expressional changes in growth and inflammatory mediators during Achilles tendon repair in diabetic rats: new insights into a possible basis for compromised healing

Ahmed, A. S., Li, J., Schizas, N., Ahmed, M., Östenson, C., SALO, P. T., Hewitt, C., Hart, D. A., & Ackermann, P. W. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1871-3 · Cited by 29

Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting

Lim, S. H., Kim, C., Aref, A. R., Kamm, R. D., & Raghunath, M. (2013) · Integrative Biology · doi:10.1039/c3ib40082d · Cited by 29

High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages

Terán, G., Li, H., Catrina, S., Liu, R., Brighenti, S., Zheng, X., Grünler, J., Nylén, S., Carow, B., & Rottenberg, M. E. (2022) · mBio · doi:10.1128/mbio.01086-22 · Cited by 29

Role of Hypoxia in Mesenchymal Stem Cells from Dental Pulp: Influence, Mechanism and Application

Ma, M. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01274-0 · Cited by 34

Controlled delivery of HIF-1α via extracellular vesicles with collagen-binding activity for enhanced wound healing

Jeon, S., Cho, S., Yoo, S., Lee, Y., Goo, J., Jeong, Y. J., Nam, G., Shin, H., Park, J., Jeong, C., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.02.010 · Cited by 28

Molecular mechanisms of skin wound healing in non-diabetic and diabetic mice in excision and pressure experimental wounds

Baldassarro, V. A., Lorenzini, L., Giuliani, A., Cescatti, M., Alastra, G., Pannella, M., Imbimbo, B. P., Villetti, G., Calzà, L., & Giardino, L. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03624-x · Cited by 28

Prevention of skin flap necrosis by use of adipose-derived stromal cells with light-emitting diode phototherapy

Park, I., Mondal, A., Chung, P., & Ahn, J. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.10.017 · Cited by 28

High glucose concentrations attenuate hypoxia-inducible factor-1α expression and signaling in non-tumor cells

Dehne, N., Hintereder, G., & Brüne, B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.019 · Cited by 28

Hypoxia, hypoxia-inducible factor-1α and vascular endothelial growth factor in a murine model of Schistosoma mansoni infection

Araújo, A. P., Frezza, T. F., Allegretti, S. M., & Giorgio, S. (2010) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.09.003 · Cited by 28

Hypoxia in Skin Cancer: Molecular Basis and Clinical Implications

Jeon, S., Jeon, M., Choi, S., Yoo, S., Park, S.-H., Lee, M., & Kim, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054430 · Cited by 27

Hypoxic environment of wounds and photosynthesis-based oxygen therapy

Tian, S., Tan, S., Fan, M., Gong, W., Yang, T., Jiao, F., & Qiao, H. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae012 · Cited by 32

Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges

Schneider, M., Harnoss, J. M., Strowitzki, M. J., Radhakrishnan, P., Platzer, L. K., Harnoss, J. C., Hank, T. P., Cai, J., & Ulrich, A. B. (2015) · Hypoxia · doi:10.2147/hp.s60872 · Cited by 26

NF-κB suppresses HIF-1α response by competing for P300 binding

Mendonça, D. B. S., Mendonça, G., Aragão, F. J. L., & Cooper, L. F. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.098 · Cited by 27

Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells

Sabatini, P. V., Speckmann, T., Nian, C., Glavas, M. M., Wong, C. K., Yoon, J. S., Kin, T., Shapiro, A. M. J., Gibson, W. T., Verchere, C. B., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.033 · Cited by 28

Antimycotic Ciclopirox Olamine in the Diabetic Environment Promotes Angiogenesis and Enhances Wound Healing

Ko, S. H., Nauta, A., Morrison, S. D., Zhou, H., Zimmermann, A. S., Gurtner, G. C., Ding, S., & Longaker, M. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027844 · Cited by 27

JinChan YiShen TongLuo Formula ameliorate mitochondrial dysfunction and apoptosis in diabetic nephropathy through the HIF-1α-PINK1-Parkin pathway

Zheng, Q., Zhang, X., Guo, J., Wang, Y., Jiang, Y., Li, S., Liu, Y., & Liu, W. J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117863 · Cited by 28

Nanoscale Systems for Local Activation of Hypoxia-Inducible Factor-1 Alpha: A New Approach in Diabetic Wound Management

Saber, S., Abdelhady, R., Elhemely, M. A., Elmorsy, E. A., Hamad, R. S., Abdel‐Reheim, M. A., El-kott, A. F., AlShehri, M. A., Morsy, K., Negm, S., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s497041 · Cited by 30

Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells

Sarkar, K., Rey, S., Zhang, X., Sebastian, R., Marti, G. P., Fox-Talbot, K., Cardona, A. V., Du, J., Tan, Y. S., Liu, L., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr282 · Cited by 28

Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy

Ekberg, N. R., Eliasson, S., Li, Y. W., Zheng, X., Chatzidionysiou, K., Falhammar, H., Gu, H. F., & Catrina, S. (2019) · Journal of Diabetes Research · doi:10.1155/2019/2936962 · Cited by 26

Insulin-Containing Wound Dressing Promotes Diabetic Wound Healing Through Stabilizing HIF-1α

Yang, P., Wang, D., Shi, Y., Li, M., Gao, M., Yu, T., Liu, D., Zhang, J., Wang, J., Zhang, X., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.592833 · Cited by 26

Non-Invasive Assessment of Vascular Circulation Based on Flow Mediated Skin Fluorescence (FMSF)

Marcinek, A., Katarzyńska, J., Sieroń, L., Skokowski, R., Zieliński, J., & Gebicki, J. L. (2023) · Biology · doi:10.3390/biology12030385 · Cited by 25

Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications

Solanki, A. K., Autefage, H., Rodriguez, A. R., Agarwal, S., Penide, J., Mahat, M., Whittaker, T. E., Nommeots‐Nomm, A., Littmann, E., Payne, D. J., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1125060 · Cited by 26

Effects of Transient Hypoxia versus Prolonged Hypoxia on Satellite Cell Proliferation and Differentiation In Vivo

Jash, S., & Adhya, S. (2015) · Stem Cells International · doi:10.1155/2015/961307 · Cited by 26

Does Diabetes Mellitus Affect Tendon Healing?

Ahmed, A. S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-33943-6_16 · Cited by 26

Physiology and Pathophysiology of Wound Healing in Diabetes

Pastar, I., Balukoff, N. C., Sawaya, A. P., Vecin, N. M., & Tomic‐Canic, M. (2024) · Contemporary diabetes · doi:10.1007/978-3-031-55715-6_7 · Cited by 27

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate

Botusan, I. R., Zheng, X., Narayanan, S., Grünler, J., Sunkari, V. G., Calissendorff, F. S., Ansurudeen, I., Illies, C., Svensson, J., Jansson, J., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193084 · Cited by 25

LOXL2 upregulates hypoxia‑inducible factor‑1α signaling through Snail‑FBP1 axis in hepatocellular carcinoma cells

Fan, Z., Zheng, W., Li, H., Wu, W., Liu, X., Sun, Z., Hu, H., Du, L., Jia, Q., & Liu, Q. (2020) · Oncology Reports · doi:10.3892/or.2020.7541 · Cited by 25

Four‐Arm Polymer‐Guided Formation of Curcumin‐Loaded Flower‐Like Porous Microspheres as Injectable Cell Carriers for Diabetic Wound Healing

Yuan, X., Yang, W. B., Fu, Y., Tao, Z., Xiao, L., Zheng, Q., Wu, D., Zhang, M., Li, L., Lu, Z., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301486 · Cited by 25

Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes

Savu, O., Sunkari, V. G., Botusan, I. R., Grünler, J., Nikoshkov, A., & Catrina, S. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1203 · Cited by 25

Epidermal Deletion of HIF-2α Stimulates Wound Closure

Cowburn, A. S., Alexander, L. E. C., Southwood, M. R., Nizet, V., Chilvers, E. R., & Johnson, R. S. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.395 · Cited by 25

Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration

Tang, D., Yan, T., Zhang, J., Jiang, X., Zhang, D., & Huang, Y. (2017) · Scientific Reports · doi:10.1038/srep43926 · Cited by 26

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment

Marín-Luevano, P., Trujillo, V., Rodríguez-Carlos, A., Gonzalez-Curiel, I. E., Enciso‐Moreno, J. A., Hancock, R. E. W., & Rivas-Santiago, B. T. (2018) · Peptides · doi:10.1016/j.peptides.2018.01.010 · Cited by 25

Gene-engineered polypeptide hydrogels with on-demand oxygenation and ECM-cell interaction mimicry for diabetic wound healing

Xie, X., Gao, C., Tan, L.-F., Chen, L., Fan, J., Xiong, W. H., Cheng, K., Zhao, Y., & Лю, Б. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122984 · Cited by 25

Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells

Mittal, K., Choi, D. H., Ogden, A., Donthamsetty, S., Melton, B. D., Gupta, M. V., Pannu, V., Cantuaria, G. H., Varambally, S., Reid, M. D., et al. (2017) · Scientific Reports · doi:10.1038/srep43984 · Cited by 24

Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats

Qayoom, A., Aneesha, V. A., Anagha, S., Dar, J. A., Kumar, P., & Kumar, D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172478 · Cited by 24

Skin well-being in diabetes: Role of macrophages

Yaseen, H., & Khamaisi, M. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104154 · Cited by 24

Photothermal Controlled‐Release Immunomodulatory Nanoplatform for Restoring Nerve Structure and Mechanical Nociception in Infectious Diabetic Ulcers

Jiang, L., Wu, X., Wang, Y., Liu, C., Wu, Y., Wang, J., Xu, N., He, Z., Wang, S., Zhang, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202300339 · Cited by 24

Vascular regeneration effect of adipose-derived stem cells with light-emitting diode phototherapy in ischemic tissue

Park, I., Mondal, A., Chung, P., & Ahn, J. (2015) · Lasers in Medical Science · doi:10.1007/s10103-014-1699-9 · Cited by 24

William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award

Hurst, J. H. (2016) · Journal of Clinical Investigation · doi:10.1172/jci90055 · Cited by 27

Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?

Pirri, D., Fragiadaki, M., & Evans, P. C. (2020) · Bioscience Reports · doi:10.1042/bsr20200026 · Cited by 26

Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention

Guillemot‐Legris, O., Buisseret, B., Mutemberezi, V., Hermans, E., Deumens, R., Alhouayek, M., & Muccioli, G. G. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.022 · Cited by 23

PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation

Qiu, J., Shu, C., Li, X., & Zhang, W.-C. (2022) · Laboratory Investigation · doi:10.1038/s41374-022-00786-8 · Cited by 23

High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes

Rahmoon, M. A., Elghaish, R. A., Ibrahim, A. A., Alaswad, Z., Gad, M. Z., El‐Khamisy, S. F., & Elserafy, M. (2023) · Genes · doi:10.3390/genes14010144 · Cited by 25

A Sequential Dual Functional Supramolecular Hydrogel with Promoted Drug Release to Scavenge ROS and Stabilize HIF‐1α for Myocardial Infarction Treatment

Wang, K., Yao, S., Wang, Z., Shen, L., Guo, D., Zhu, Y., Yang, X., Yu, Q., & Gao, C. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302940 · Cited by 23

L‐mimosine increases the production of vascular endothelial growth factor in human tooth slice organ culture model

Trimmel, K., Cvikl, B., Müller, H. ‐., Nürnberger, S., Gruber, R., Moritz, A., & Agis, H. (2014) · International Endodontic Journal · doi:10.1111/iej.12307 · Cited by 24

Mono-epoxy-tocotrienol-α enhances wound healing in diabetic mice and stimulates in vitro angiogenesis and cell migration

Xu, C., Bentinger, M., Savu, O., Moshfegh, A., Sunkari, V. G., Dallner, G., Świeżewska, E., Catrina, S., Brismar, K., & Tekle, M. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.010 · Cited by 24

Tibial Cortex Transverse Transport Facilitates Severe Diabetic Foot Wound Healing via HIF-1α-Induced Angiogenesis

Liu, J., Huang, X., Su, H., Yu, J., Nie, X., Liu, K., Qin, W., Zhao, Y., Su, Y., Kuang, X., et al. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s456590 · Cited by 22

Bioengineered Skin Substitute Considerations in the Diabetic Foot Ulcer

Widgerow, A. D. (2013) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e31826eac22 · Cited by 22

Prolyl hydroxylase domain inhibitors: can multiple mechanisms be an opportunity for ischemic stroke?

Lanigan, S. M., & O'Connor, J. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.021 · Cited by 22

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Lang, X., Li, L., Li, Y., & Feng, X. (2024) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s457498 · Cited by 22

Synergistic Effect of Prolonged Oxygenation and Reactive Oxygen Species Scavenging on Diabetic Wound Healing Using an Injectable Thermoresponsive Hydrogel

Lee, J., Kim, J., Kim, J., & Song, S. (2025) · Small · doi:10.1002/smll.202502399 · Cited by 22

Multi‐Enzyme Mimetic Microneedles with Spatiotemporal Control: Eradicating Biofilms, Resolving Oxidative Stress, and Revascularizing Diabetic Wounds

Zhang, J., Luo, X., Hu, Y., Gao, B., Tang, X., Fang, S., Ou, B., Sheng, X., Su, J., & Feng, J. (2025) · Small · doi:10.1002/smll.202505277 · Cited by 21

Hif‐1alpha stabilisation is protective against infection in zebrafish comorbid models

Schild, Y., Mohamed, A., Wootton, E. J., Lewis, A., & Elks, P. M. (2020) · FEBS Journal · doi:10.1111/febs.15433 · Cited by 21

Pro- and Anti-Angiogenic Factors: Their Relevance in Diabetic Foot Syndrome—A Review

Schönborn, M., Łączak, P., Pasieka, P., Borys, S., Płotek, A., & Maga, P. (2021) · Angiology · doi:10.1177/00033197211042684 · Cited by 21

Roxadustat, a HIF-PHD inhibitor with exploitable potential on diabetes-related complications

Fang, T., Ma, C., Zhang, Z., Sun, L., & Zheng, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1088288 · Cited by 24

The Prolyl Hydroxylase Inhibitor Dimethyloxalylglycine Enhances Dentin Sialophoshoprotein Expression through VEGF-Induced Runx2 Stabilization

Rahman, S. U., Lee, M.-S., Baek, J., Ryoo, H., & Woo, K. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112078 · Cited by 22

Spatiotemporal variations of vascular endothelial growth factor in the brain of diabetic cognitive impairment

Yin, Q., Ma, J., Han, X., Zhang, H., Wang, F., Zhuang, P., & Zhang, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105234 · Cited by 21

Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits

Matsuura, Y., Yamashita, A., Zhao, Y., Iwakiri, T., Yamasaki, K., Sugita, C., Koshimoto, C., Kitamura, K., Kawai, K., Tamaki, N., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175976 · Cited by 20

The Role of miR-181c in Mechanisms of Diabetes-Impaired Angiogenesis: An Emerging Therapeutic Target for Diabetic Vascular Complications

Solly, E. L., Psaltis, P. J., Bursill, C. A., & Tan, J. T. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.718679 · Cited by 20

PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF‐1α protein stability and gene expression

Ma, Z., Mo, R., Yang, P., Ding, Y., Zhang, H., Dong, Z. F., Chen, Y., & Tan, Q. (2023) · The FASEB Journal · doi:10.1096/fj.202300874rr · Cited by 21

The sweet side of HIF

Haase, V. H. (2010) · Kidney International · doi:10.1038/ki.2010.112 · Cited by 20

Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice

Bohuslavová, R., Kolář, F., Sedmera, D., Skvorova, L., Papoušek, F., Neckář, J., & Pavlínková, G. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-11 · Cited by 23

Angiogenic Synergistic Effect of Adipose-Derived Stromal Cell Spheroids with Low-Level Light Therapy in a Model of Acute Skin Flap Ischemia

Park, I., Chung, P., & Ahn, J. (2016) · Cells Tissues Organs · doi:10.1159/000445710 · Cited by 20

Hypoxia-based strategies for regenerative dentistry—Views from the different dental fields

Müller, A. S., Janjić, K., Lilaj, B., Edelmayer, M., & Agis, H. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.04.029 · Cited by 20

Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs

Gaspar, D., Peixoto, R., Pieri, A. D., Striegl, B., Zeugolis, D. I., & Raghunath, M. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.06.002 · Cited by 21

Non-invasive monitoring of pharmacodynamics during the skin wound healing process using multimodal optical microscopy

Rico-Jimenez, J. J., Lee, J. H., Alex, A., Musaad, S. M. A., Chaney, E. J., Barkalifa, R., Spillman, D. R., Olson, E., Adams, D. F., Marjanović, M., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000974 · Cited by 20

Oxygen-Releasing Composites: A Promising Approach in the Management of Diabetic Foot Ulcers

Lim, D., & Insoo, J. (2021) · Polymers · doi:10.3390/polym13234131 · Cited by 21

Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases

Lee, M. J., Kim, J. W., & Yang, E. G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.099 · Cited by 19

Using systems biology approaches to identify signalling pathways activated during chronic wound initiation

Basu, P., Kim, J. H., Saeed, S., & Martins‐Green, M. M. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12963 · Cited by 20

Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 improves diabetic wound healing

Yue, H., Song, P., Sutthammikorn, N., Umehara, Y., Trujillo-Páez, J. V., Nguyen, H. L. T., Takahashi, M., Peng, G., Ikutama, R., Okumura, K., et al. (2022) · Wound Repair and Regeneration · doi:10.1111/wrr.12997 · Cited by 19

Mangiferin alleviates hyperglycemia-induced endothelial impairment via Nrf2 signaling pathway

Jayasuriya, R., & Ramkumar, K. M. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175359 · Cited by 19

Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing

Scott, C., Bonner, J. G., Min, D., Boughton, P. C., Stokes, R., Cha, K. M., Walters, S. N., Maslowski, K. M., Sierro, F., Grey, S. T., et al. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00306.2013 · Cited by 19

Constitutive expression of hypoxia‐inducible factor‐1 α in keratinocytes during the repair of skin wounds in horses

Deschêne, K., Céleste, C., Boerboom, D., & Theoret, C. L. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00663.x · Cited by 19

Impaired response of mature adipocytes of diabetic mice to hypoxia

Hong, S. J., Jin, D. P., Buck, D. W., Galiano, R. D., & Mustoe, T. A. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.07.004 · Cited by 19

Hypoxia inducible factor HIF-1α stabilization as a transformative approach in overcoming diabetic wound healing challenges

Bogadi, S., Uddin, M. E., Karri, V. V. S. R., Begum, R., kader, M. A., Abullais, S. S., Reza, M. S., & Haque, M. S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107296 · Cited by 15

Sustained expression of Hif‐1α in the diabetic environment promotes angiogenesis and cutaneous wound repair

Mace, K. A., Yu, D. H., Paydar, K. Z., Boudreau, N. J., & Young, D. M. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00278.x · Cited by 182

A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Li, G., Ko, C.-N., Li, D., Yang, C., Wang, W., Yang, G., Primo, C. D., Wong, V. K. W., Xiang, Y., Lin, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23448-7 · Cited by 263

Harnessing HIF-1α for Diabetic Wound Healing: From Molecular Insights to Therapeutic Strategies

Mariappan, E., Swaroop, A. K., RajanBabu, S., Natarajan, J., Kunjiappan, S., Thangavelu, P., & Selvaraj, J. (2026) · Current Drug Targets · doi:10.2174/0113894501394451251128123942 · Cited by 1

Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function

Catrina, S., Okamoto, K., Pereira, T., Brismar, K., & Poellinger, L. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3226 · Cited by 394