Cited by 534Wound Healing and TreatmentsCancer, Hypoxia, and MetabolismDiabetic Foot Ulcer Assessment and Management

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Stabilization of HIF-1α is critical to improve wound healing in diabetic mice

Open access

Botusan, Ileana Ruxandra, Sunkari, Vivekananda Gupta, Savu, Octavian, Catrina, Anca Irinel, Grünler, Jacob, Lindberg, Stina, Pereira, Teresa, Ylä-Herttuala, Seppo, Poellinger, Lorenz, Brismar, Kerstin, Catrina, Sergiu-Bogdan·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0805230105PMC PMC2614777

Open this paper in CoChat — free account

Abstract

Relative hypoxia is essential in wound healing since it normally plays a pivotal role in regulation of all the critical processes involved in tissue repair. Hypoxia-inducible factor (HIF) 1α is the critical transcription factor that regulates adaptive responses to hypoxia. HIF-1α stability and function is regulated by oxygen-dependent soluble hydroxylases targeting critical proline and asparaginyl residues. Here we show that hyperglycemia complexly affects both HIF-1α stability and activation, resulting in suppression of expression of HIF-1 target genes essential for wound healing both in vitro and in vivo . However, by blocking HIF-1α hydroxylation through chemical inhibition, it is possible to reverse this negative effect of hyperglycemia and to improve the wound healing process (i.e., granulation, vascularization, epidermal regeneration, and recruitment of endothelial precursors). Local adenovirus-mediated transfer of two stable HIF constructs demonstrated that stabilization of HIF-1α is necessary and sufficient for promoting wound healing in a diabetic environment. Our findings outline the necessity to develop specific hydroxylase inhibitors as therapeutic agents for chronic diabetes wounds. In conclusion, we demonstrate that impaired regulation of HIF-1α is essential for the development of diabetic wounds, and we provide evidence that stabilization of HIF-1α is critical to reverse the pathological process.

Integrity signals

Registry

Crossref · 10.1073/pnas.0805230105

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
The global burden of diabetic foot disease
Boulton, A. J. M., Vileikytė, L., Tennvall, G. R., & Apelqvist, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67698-2 · Cited by 2,578
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558
Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350
Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.
Frank, S., Hübner, G., Breier, G., Longaker, M. T., Greenhalgh, D. G., & Werner, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12607 · Cited by 764

Show all 39 references

Sorted by citations

Items 401–500 of 534

Effect of N-acyl-dopamines on beta cell differentiation and wound healing in diabetic mice
Jiménez‐Jiménez, C., Lara‐Chica, M., Palomares, B., Collado, J. A., López‐Miranda, J., Muñóz, E., & Calzado, M. A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.08.008 · Cited by 6
Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice
Scott, C. H., Cha, K. M., Ngai, J., Jiang, C., Cheng, K., Stokes, R., Ho, K., George, J., Gonzalez, F. J., & Gunton, J. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186543 · Cited by 6
Changing the Wound: Covalent Immobilization of the Epidermal Growth Factor
Raghunathan, V. K., Park, S. A., Shah, N. M., Reilly, C. M., Teixeira, L. B. C., Dubielzig, R. R., Chang, Y.-R., Motta, M. J., Schurr, M. J., McAnulty, J. F., et al. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00192 · Cited by 7
[Effect of Cordyceps sinensis on expressions of HIF-1α and VEGF in the kidney of rats with diabetic nephropathy].
Yuan, M., Tang, R., Zhou, Q., Liu, K., Xiao, Z. S., & Veeraragoo, P. (2013) · PubMed · doi:10.3969/j.issn.1672-7347.2013.05.003 · Cited by 6
Evaluation of angiogenesis in diabetic lower limb wound healing using a natural medicine: A quantitative approach
Barui, A., Banerjee, P., Chaudhary, A., Conjeti, S., Mondal, B., Dey, S., & Chatterjee, J. (2014) · Wound Medicine · doi:10.1016/j.wndm.2014.09.003 · Cited by 6
Neovascularization in diabetes
Glotzbach, J. P., Wong, V., & Gurtner, G. C. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.57 · Cited by 6
Nanozyme-based Therapeutic Systems for Diabetic Wound Treatment
Luo, Z., Jiang, S., Wu, Y., & Li, Z. (2023) · Therapeutic Delivery · doi:10.4155/tde-2023-0008 · Cited by 6
FG-4592 combined with PRP significantly accelerates the healing of refractory diabetic wounds by upregulating HIF-1α
Tang, D., Lin, Q., Li, P.-W., Wang, S., Xu, K., Huang, Y., & Lu, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-99356-3 · Cited by 6
Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes
Conboy, J. J. M. J. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000289 · Cited by 5
Artificial intelligence-aided discovery of prolyl hydroxylase 2 inhibitors to stabilize hypoxia inducible factor-1α and promote angiogenesis
Zhu, J., Chen, C. Y., Dong, J., Cheng, S., Li, G., Wang, C., Ouyang, D., Leung, C., & Lin, L. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.05.028 · Cited by 5
Analysis of Bulk Transcriptome Sequencing Data and in vitro Experiments Reveal SIN3A as a Potential Target for Diabetic Foot Ulcer
Chen, R., Deng, H., & Zou, L. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s439924 · Cited by 5
Graphene oxide-loaded rapamycin coating on airway stents inhibits stent-related granulation tissue hyperplasia
Li, Z., Lu, X., Wu, K., Wang, J., Li, Y., Li, Y., Ren, K., & Han, X. (2024) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezae270 · Cited by 5
Roles of Chinese medicine bioactive ingredients in the regulation of cellular function of endothelial progenitor cells
Zhao, Q., Li, B., & Kong, H. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60075-3 · Cited by 5
Deferoxamine enhances the migration of dental pulp cells via hypoxia-inducible factor 1α.
Du, R., Zhao, J., Wen, Y., Zhu, Y., & Jiang, L. (2021) · PubMed Central · Cited by 5
Reciprocal role of PLAP‐1 in HIF‐1α‐mediated responses to hypoxia
Takedachi, M., Yamamoto, S., Kawasaki, K., Shimomura, J., Murata, M., Morimoto, C., Hirai, A., Kawakami, K., Bhongsatiern, P., Iwayama, T., et al. (2022) · Journal of Periodontal Research · doi:10.1111/jre.12976 · Cited by 5
Challenges and Opportunities in Drug Delivery for Wound Healing
Aitzetmüller, M. M., Machens, H., & Duscher, D. (2018) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_91 · Cited by 5
Role of HIF1α and PKCβ in mediating the effect of oxygen and glucose in a novel wound assay
Gadad, P. C., Matthews, K. H., & Knott, R. M. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.03.008 · Cited by 5
Nutrient Matrix-Supplying Hydrogel for Chlorella vulgaris Promotes Diabetic Wound Healing
Zhang, H., Liu, D., Lv, Y., Liu, C., Cao, X., Dai, J., Chai, Y., & Chen, W. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01857 · Cited by 4
Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair
Kwak, M., Choi, E., Jo, Y., Kim, B., Lim, C. B., Lim, J., Choi, Y. H., Lee, J. H., Kim, K.-P., Koo, B., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69047-2 · Cited by 5
The adverse effects of persistent wound stress on patients with type 2 diabetes. Part 1: Pathophysiological mechanisms and multi-organ impacts
Gao, C., Cai, X., Li, J., Jiang, J., Bo, Q. I. A. N., Yang, R., & Xiong, F. (2026) · Burns · doi:10.1016/j.burns.2026.107874 · Cited by 4
Revascularization-driven nanozyme Therapy: Disrupting the vicious cycle of ROS and insufficient vascularization for chronic non-healing wound treatment
Jiang, Q., Zhang, M., Yang, Y., Jin, M., Zhao, J., Chen, D., Jiang, B., Li, M., Ma, J., Li, J., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124081 · Cited by 4
Assessment of the Polyphenolic Profile and Beneficial Effects of Red and Green Propolis in Skin Inflammatory Conditions and Oxidative Stress
Magnavacca, A., Martinelli, G., Maranta, N., Pozzoli, C., Fumagalli, M., Beretta, G., Piazza, S., Dell’Agli, M., & Sangiovanni, E. (2025) · Biomedicines · doi:10.3390/biomedicines13092229 · Cited by 4
Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy
Vestergaard, M. B., Laursen, J. C., Heinrich, N. S., Rossing, P. R., Hansen, T. W., & Larsson, H. B. W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1229509 · Cited by 4
Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression
Saienko, Y. A., Gonchar, O. O., Im, M., Drevytska, T., Bratus, L. V., & Mankovsky, B. (2023) · The Ukrainian Biochemical Journal · doi:10.15407/ubj95.02.048 · Cited by 4
NRP-1 Receptor Expression Mismatch in Skin of Subjects with Experimental and Diabetic Small Fiber Neuropathy
Acker, N. V., Ragé, M., Vermeirsch, H., Schrijvers, D. M., Nuydens, R., Byttebier, G., Timmers, M., Schepper, S. D., Streffer, J. R., Andries, L. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161441 · Cited by 4
Dimethyloxalylglycine (DMOG) and the Caspase Inhibitor “Ac-LETD-CHO” Protect Neuronal ND7/23 Cells of Gluocotoxicity
Mukhopadhyay, D., Hammami, M. B., Khalouf, A., Shaikh, Y. A., Mohammed, A. K., Hamad, M. A., Salehi, A. A., & Taneera, J. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0919-4489 · Cited by 4
Peptides and Wound Healing: From Monomer to Combination
Liu, C., Yang, Q., & Zhou, Y. L. (2024) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-024-10627-5 · Cited by 3
Therapeutic potential of copper II oxide in treating diabetic wounds: an emerging approach for enhanced healing
Bogadi, S., Uddin, M. E., Karri, V. V. S. R., Begum, R., Kader, M. A., Abullais, S. S., Reza, M. S., Alexiou, A. T., & Papadakis, M. (2025) · Acta Diabetologica · doi:10.1007/s00592-025-02582-4 · Cited by 3
Non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy promote diabetic wound healing
Huang, Y., Qin, P., Zhou, P., Long, B., Zhang, S., Gao, R., Zhu, B., Li, Y., & Li, Q. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00344-9 · Cited by 3
β-Cell Deletion of Hypoxia-Inducible Factor 1α (HIF-1α) Increases Pancreatic β-Cell Susceptibility to Streptozotocin
Yu, J., Lalwani, A., & Gunton, J. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413451 · Cited by 4
Design and Development of Fiber Patch to Prevent Reperfusion Injury and Provide Thermal Stimulation for Treating Severe Frostbite
Li, X., Pan, J., Liu, M., Zhang, E., Li, Y., He, Y., Yang, G., & Zhou, S. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202503172 · Cited by 3
The impact of diabetes on treatment in general dental practice
Yeung, V., & Chandan, J. S. (2018) · Dental Update · doi:10.12968/denu.2018.45.2.120 · Cited by 3
Extracellular HSP90α Versus Intracellular HSP90β in Wound Healing and Cancer
Lincoln, V., Tang, X., Chen, M., & Li, W. S. (2019) · Heat shock proteins · doi:10.1007/978-3-030-03952-3_15 · Cited by 3
Longitudinal physiological remoulding of lower limb skin as a cause of diabetic foot ulcer: a histopathological examination
Imamura, Y., Suzuki, K., Saijo, H., & Tanaka, K. (2022) · Journal of Wound Care · doi:10.12968/jowc.2022.31.sup8.s29 · Cited by 3
Phloridzin's Diabetic Wound Healing Potential through DPP-4 Enzyme Inhibition: A Review Article
Sharma, K., Ramachandran, V., Sharma, A., Mohanasundaram, T., & Magesh, H. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998291941240416053855 · Cited by 3
Potential roles of histone deacetylases in diabetic wound healing
Zhang, F., Ma, H., Zhang, B., Jiang, L.-L., Nie, K., Deng, C., & Liu, Y. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i10.108346 · Cited by 3
Biochemical and Immunomorphological Evaluation of Hepatocyte Growth Factor and c-Met Pathway in Patients with Critical Limb Ischemia
Vasuri, F., Fittipaldi, S., Abualhin, M., Degiovanni, A., Gargiulo, M., Stella, A., & Pasquinelli, G. (2014) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2014.05.002 · Cited by 3
Challenges and Opportunities in Drug Delivery and Wound Healing
Aitzetmüller, M. M., Machens, H., & Duscher, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-19962-3_3 · Cited by 3
Formulating curcumin in a biodegradable polymeric composite material: a step towards wound healing applications
Shahnia, M. (2017) · Minerva Access (University of Melbourne) · Cited by 3
Insight into the research frontier of hypoxia in skin health and diseases: a bibliometric analysis
Huang, C., Li, X., Li, J., Wang, W., Mou, X., Huoshen, W., Liu, N., Xiong, X., Yi, S., Zhong, G., et al. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000003303 · Cited by 2
Pre-Vascularized 3-Dimensional Skin Substitutes Promote Angiogenesis and Tissue Repair in a Murine Model of Refractory Skin Ulcers
Tojo, S., Miyazaki, H., Saiki, T., Tsunoi, Y., Nakamura, S., & Azuma, R. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16110409 · Cited by 2
Hypoxia-Inducible Factor 1-α in Autoimmune Diseases—Insights from the Paradigm of Hashimoto’s Thyroiditis: A Narrative Review
Srb, N., Milostić-Srb, A., Sarić, L., Holik, D., Šapina, M., Fureš, R., Talapko, J., Škrlec, I., Katalinić, D., & Kovačić, B. (2026) · Medical Sciences · doi:10.3390/medsci14010061 · Cited by 2
Branch-chain amino acid accumulation: multiple roles in the pathogenesis of diabetic foot ulcers
Tang, M., Feng, J., Ni, Y., Zhang, W., Zhou, M., & Zhao, C. (2026) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2026.113255 · Cited by 2
Local stabilization of HIF-1α via deferoxamine-loaded collagen–chitosan sponge scaffold accelerates healing of type 2 diabetic wounds in rats
Alshaghdali, K., Alghamdi, S. A., Binshaya, A. S., Juraybi, T. N., Alghamdi, A. A., Abalkhail, A., Altarjami, L. R., & Alissa, M. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103538 · Cited by 2
Hypoxia-mimetic activation of HIF-1α by a DMOG-loaded collagen scaffold enhances angiogenesis and tissue remodeling in type 2 diabetic wounds
Hjazi, A. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103721 · Cited by 2
A study of the genotyping and vascular endothelial growth factor polymorphism differences in diabetic and diabetic retinopathy patients
Wagih, S., Hussein, M. M., Rizk, K. A., Azeem, A. A. A., & El-Habit, O. H. (2022) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-022-00277-x · Cited by 2
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection
Tu, Y., Pan, C., Huang, Y., Ye, Y., Zheng, Y., Cao, D., & Lv, Y. (2025) · Lasers in Medical Science · doi:10.1007/s10103-025-04294-1 · Cited by 2
New pathogenic mechanisms in diabetic wound healing
Sunkari, V. G. (2012) · Figshare · Cited by 2
Self-citation
Tendon Homeostasis: Overview
Ilaltdinov, A. W., Gong, Y., Leong, D. J., Fung, D. T. H., & Sun, H. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11580-6 · Cited by 2
Vascularization of 3D Engineered Tissues
Ju, Y. M., Atala, A., & Yoo, J. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-05336-9_22 · Cited by 1
Combination Strategy of Two Hydrogels Loaded with Prussian Blue Nanoparticles and Calcium Peroxide Separately for Diabetic Wound Repair
Chai, S., Li, F., Zhang, C., Liu, T., Han, C., Zhang, Q., & Sui, X. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c02549 · Cited by 1
Selective Autophagy: A Potential Player in Cutaneous Wound Healing
Jin, W., Ren, D., Yu, M., Li, Y., Zhang, W., & Guo, S. (2025) · Advances in Wound Care · doi:10.1177/21621918251372954 · Cited by 1
Retinal detachment risk in a cohort of von Hippel-Lindau patients at a Major U.S. tertiary care facility
Baroutis, K. G., Sakuno, G., Hoyek, S., Patel, N. A., Miller, J. W., & Vavvas, D. G. (2025) · AJO International · doi:10.1016/j.ajoint.2025.100183 · Cited by 1
Exosomes from adipose-derived stem cells: A potential therapeutic strategy for diabetic foot ulcers
Mao, J.-X., Chen, S., Li, J., Wang, H., & Zhao, M. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i10.109763 · Cited by 3
WITHDRAWN: The Adverse Effects of Persistent Wound Stress on Patients with Type 2 Diabetes
Gao, C., Cai, X., Li, J., Jiang, J., Qian, B., Yang, R., & Xiong, F. (2025) · Burns · doi:10.1016/j.burns.2025.107765 · Cited by 1
Retracted
The Interplay Between Stiffness and Hyperglycemia on Diabetic Foot Ulcer Wound Closure
Albeltagy, N., Patten, J., & Wang, K. (2026) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-025-00877-8 · Cited by 1
Therapeutic Hydrogel Microneedle Patch for Burn Wound Field Care
Thompson, M. A., Saul‐McBeth, J., Sadeqi, A., Zuniga, K., Sonkusale, S., Stavena-Holik, M., Brizzi, L., Larson, D. A., McGinnis, K., Chambers-Wilson, R., et al. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01136 · Cited by 1
CD73+ mesenchymal stem cell (MSC) transplantation improves pressure ulcer healing by promoting angiogenesis through the HIF-1α/VEGF pathway in diabetic mice
Hou, H., Zhang, D., Wang, S., Zheng, M., Bai, X., Wang, G., Xu, X., Guo, Z., Li, Z., & Li, Q. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.114971 · Cited by 1
Smart Nanocarrier Systems for Diabetic Wound Healing: Preclinical Innovations and Clinical Progress in Drug and Gene Delivery
Bhat, P., Satapathy, A., Yadav, N., Satapathy, A., Chandrakar, K., Satapathy, A., Bhardwaj, S. K., & Patel, N. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i3.7630 · Cited by 1
Platelet-membrane-coated photosynthetic oxygen production system for diabetic wound repair
Pan, K., Huang, Z., Tian, H., Dai, Z., Yu, J., Yang, K., Wang, Y., Zhu, J., Wang, Q., Fan, S., et al. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2026.103401 · Cited by 1
Hypoxia-Inducible Factor 1α in Type 2 Diabetes Mellitus: Mechanisms and Therapeutic Perspectives
Jia, J., Lu, Q., Zhang, Y., & Zhao, Y. (2026) · Biology · doi:10.3390/biology15151241 · Cited by 1
The ROS Gatekeeper Hypothesis: A Conceptual Framework for Gasotransmitter Signaling in Pressure Ulcers
Shinkai, R., Tsukase, N., Nishizawa, Y., Nomura, A., & Tomita, T. (2026) · Oxygen · doi:10.3390/oxygen6030024 · Cited by 1
Bioadhesive hydrogels as immunomodulatory interfaces for chronic wound healing: from microenvironmental regulation mechanism to engineering strategies
Son, K., Kim, S. A., Kang, M., Jo, Y., Kim, C., Park, K., Jung, Y., Kim, T. Y., & Seo, J. (2026) · Burns & Trauma · doi:10.1093/burnst/tkag055 · Cited by 1
Effect of hypoxia and hyperglycemia on cell bioenergetics
Del Sole, M. <. (2012) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/4732 · Cited by 1
After Conventional Wisdom Has Failed, What Drives Wound Healing?
Lincoln, V., Tang, X., Chen, M., & Li, W. (2019) · European Medical Journal · doi:10.33590/emj/10314712 · Cited by 1
Palatoplasty using skin autograft and bovine skin xenograft for reconstituting an induced cleft in the hard palate of puppies: A comparative study
Al-Anaaz, M. T., & Al-Hyani, O. H. (2023) · Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences · doi:10.33899/ijvs.2023.137243.2659 · Cited by 1
Heat Shock Protein 90 Versus Conventional Growth Factors in Acute and Diabetic Wound Healing
Li, W., O’Brien, K., Woodley, D. T., & Chen, M. (2012) · Heat shock proteins · doi:10.1007/978-94-007-4740-1_17 · Cited by 1
Does a “thiol shield” protect tumors from natural IgM antibody, and, if so, how can it be suppressed?
Jones, P. C. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2012.12.034 · Cited by 1
Understanding regulatory pathways of neovascularization in diabetes
Maan, Z. N., Rodrigues, M., Rennert, R. C., Whitmore, A. J., Duscher, D., Januszyk, M., Hu, M. S.-M., Whittam, A. J., Davis, C. R., & Gurtner, G. C. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.938054 · Cited by 1
Engineered Proteins for Controlling Gene Expression
Gersbach, C. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10008-2 · Cited by 1
Diabetes, hypoxia and cardiovascular disease: From molecular mechanism to treatment
Ferreira, J. V. (2017) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2017.04.008 · Cited by 1
Targeting the Cellular “Oxygen Sensors”: Hypoxia Pre-Conditioning and Stabilization of Hypoxia-Inducible Factors
Agis, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-21056-8_5-1 · Cited by 1
The role of hypoxia-induced factor in the regulation of oxygen homeostasis during reparative regeneration in compromised microcirculation
Izmaylov, S. G., Beschastnov, V. V., Ryabkov, M. G., Leontev, A. E., Lukoyanychev, E. E., Bagryantsev, M. V., & Orlinskaya, N. Y. (2018) · Almanac of Clinical Medicine · doi:10.18786/2072-0505-2017-45-8-674-680 · Cited by 1
Engineered Proteins for Controlling Gene Expression
Gersbach, C. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00013-5 · Cited by 1
Diabetes, hipoxia e doenças cardiovasculares: do mecanismo molecular ao tratamento
Ferreira, J. V. (2017) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2017.03.003 · Cited by 1
Smart dressings for wound monitoring and treatment: new-type skin bioelectronic systems applicated in wound repairPreprint
Zhong, Y., Wang, Y., Hu, Y., Wang, X., Xu, F.-W., Liu, Y., Fang, Q., Zhao, W.-Y., Kuo, T.-W., Xue, Y., et al. (2021) · doi:10.22541/au.163474828.80764310/v1 · Cited by 1
Novel Cell-Based Therapies for the Treatment of Diabetic Ulceration
O’Loughlin, A. (2012) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16518
Epidermal Deletion of HIF-2a Stimulates Wound
Cowburn, C. S., Alexander, L. E. C., Southwood, M. A., Nizet, V., Chilvers, E. R., & Johnson, R. S. (2014)
Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type
DiabetesJeong, I., Conboy, M. J., & Conboy, I. M. (2013)
Wound Tissue Oximetry: A Cornerstone in Wound Care
Banerjee, J., & Sen, C. K. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2987-5_12
Rilevazione di ossigeno, omeostasi e malattia
Semenza, G. L. (2011)
Article Open Access
Lawford‐Smith, H. (2015)
Wound healing process and dipeptidyl peptidase IV
Batičić, L., Grčić, A., Pugel, E. P., Detel, D., & Varljen, J. (2017) · Medicina · doi:10.21860/medflum2017_173375
Discussion: Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention
Strong, A. L., & Lévi, B. (2018) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000004186
Therapeutic effects of Hypoxia-Inducible Factor-1α (HIF-1α) on bone formation around implants in diabetic micePreprint
Oh, S., Shin, J.-S., Kim, I.-K., Moon, J., Kim, J.-H., Lee, S.-K., & Lee, J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/392670
Quantitative characterization of cellular dynamics in wound healing using multimodal microscopy
Li, J. (2019) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Vascularization of 3D Engineered Tissues
Ju, Y. M., Atala, A., & Yoo, J. J. (2020) · Springer eBooks · doi:10.1007/978-3-319-71530-8_22-1
Commentary on: Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation
Walsh, M. D. (2020) · Aesthetic Surgery Journal · doi:10.1093/asj/sjaa205
The Roles of HIFs in the Complications of Diabetes
Yazıhan, N., & Kocak, M. K. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_8
Oxygen Sensing, Homeostasis, and Disease
Bels, D. D., Corazza, F., & Balestra, C. (2011) · New England Journal of Medicine · doi:10.1056/nejmc1110602
Dimension Controlled Polymeric Matrices and Graphene Filler-Based Nanofibres by Electrospinning
Mishra, S., Singh, A., & Singh, S. K. (2021) · Carbon nanostructures · doi:10.1007/978-3-030-75456-3_3
Targeting the Cellular “Oxygen Sensors”: Hypoxia Pre-conditioning and Stabilization of Hypoxia-Inducible Factors
Agis, H. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-319-54586-8_5
Insight into the research frontier of hypoxia in skin health and diseases: a bibliometric analysis (Preprint)Preprint
Huang, C., Li, X., Mou, X., Wang, W., Wang, W., Li, J., Liu, N., Xiong, X., Yi, S., Zhong, G., et al. (2024) · doi:10.2196/preprints.62925
Zuyangping formula promotes skin wound healing in diabetic rats.
Junhua, M., Zhang, H., Yuling, C., Zhang, Y. L., Wang, X., Bi, S., Ai, J., & Yonggang, C. (2024) · PubMed Central · doi:10.19852/j.cnki.jtcm.2024.06.008
Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Accelerates Wound Healing in a Mouse Hind limb Lymphedema Model
Ishikawa, K., Hoshino, Y., Osawa, M., Funayama, E., Miura, T., Hojo, M., Sasaki, Y., Sasaki, S., Yamamoto, Y., & Maeda, T. (2025) · Advances in Wound Care · doi:10.1089/wound.2024.0237
Investigating the Therapeutic Potential of Salvianolic Acid B in Ischemic Wound Healing: In Vivo and In Vitro Study
Tsai, Y.-T., Sun, J., Liu, Y., Chong, C.-H., Zheng, D., Zhang, Y., & Li, Y. (2025) · Aesthetic Plastic Surgery · doi:10.1007/s00266-025-04816-w
Phytomedicine as a Promising Alternative for Targeting Chronic Wounds in DiabetesPreprint
Chintala, S., & Sahu, P. K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5392548
Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive DiseasePreprint
Villar-Vesga, J., Clément, P., Hove, H. V., Meuffels, E., Bugada, V., Kim, J., Greis, D., Jorba-Adolff, P., Mayoux, M., Lasne, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.15.670462
Hypoxia inducible factor 1-α (HIF-1α) mRNA expression as a potential molecular biomarker to determine the wound age
Febrianty, A., Jerni, D. A. S. E., Muthaher, A. A., Nelwan, B. J., LAWRANCE, G. S., Achmad, D., Arsyadi, G., Dwiyanti, R., Junita, A. R., Azhar, A., et al. (2025) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.24.05722-x
Additional file 2 of Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers
Kerstan, A., Dieter, K., Niebergall‐Roth, E., Klingele, S., Jünger, M., Hasslacher, C., Daeschlein, G., Stemler, L., Meyer-Pannwitt, U., Schubert, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20967818

Authors: Botusan, I. R., Sunkari, V. G., Savu, O., Catrina, A. I., Grünler, J., Lindberg, S., Pereira, T., Ylä-Herttuala, S., Poellinger, L., Brismar, K., & Catrina, S.-B.
Affiliations: Carol Davila University of Medicine and Pharmacy (RO)
Karolinska Institutet (SE)
Karolinska University Hospital (SE)
Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
ORCID: Botusan, Ileana Ruxandra
Sunkari, Vivekananda Gupta
Savu, Octavian
Catrina, Anca Irinel
Grünler, Jacob
Pereira, Teresa
Brismar, Kerstin
Catrina, Sergiu-Bogdan
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-12-09
Volume: 105
Issue: 49
Pages: 19426-19431
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0805230105
PMC: PMC2614777
OpenAlex: W2163809998
Cited by: 533
References: 39
Citations by year: 2026: 38 · 2025: 36 · 2024: 35 · 2023: 33 · 2022: 35 · 2021: 38 · 2020: 37 · 2019: 36 · 2018: 30 · 2017: 31 · 2016: 29 · 2015: 27 · 2014: 31 · 2013: 30 · 2012: 21
FWCI: 16.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Åke Wiberg Stiftelse
Vetenskapsrådet
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords: HIF-1α, hypoxia-inducible factor, wound healing, diabetic wounds, hyperglycemia, protein stabilization, chronic wounds, granulation tissue, vascularization, epidermal regeneration, endothelial precursors, adenoviral gene transfer, diabetic mice
MeSH terms: Amino Acids, Dicarboxylic, Animals, Hypoxia, Chronic Disease, Disease Models, Animal, Enzyme Inhibitors, Fibroblasts, Humans, Mixed Function Oxygenases, Hyperglycemia, Kidney Neoplasms, Mice, Inbred C57BL, Mice, Mutant Strains, Wound Healing, Gene Expression, 3T3 Cells, Diabetic Foot, Dermis, Cell Line, Tumor, Mice, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stabilization of HIF-1α is critical to improve wound healing in diabetic mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks