The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Differential degradation of PIN2 auxin efflux carrier by retromer-dependent vacuolar targeting
Open accessAbstract
All eukaryotic cells present at the cell surface a specific set of plasma membrane proteins that modulate responses to internal and external cues and whose activity is also regulated by protein degradation. We characterized the lytic vacuole-dependent degradation of membrane proteins in Arabidopsis thaliana by means of in vivo visualization of vacuolar targeting combined with quantitative protein analysis. We show that the vacuolar targeting pathway is used by multiple cargos including PIN-FORMED (PIN) efflux carriers for the phytohormone auxin. In vivo visualization of PIN2 vacuolar targeting revealed its differential degradation in response to environmental signals, such as gravity. In contrast to polar PIN delivery to the basal plasma membrane, which depends on the vesicle trafficking regulator ARF-GEF GNOM, PIN sorting to the lytic vacuolar pathway requires additional brefeldin A-sensitive ARF-GEF activity. Furthermore, we identified putative retromer components SORTING NEXIN1 (SNX1) and VACUOLAR PROTEIN SORTING29 (VPS29) as important factors in this pathway and propose that the retromer complex acts to retrieve PIN proteins from a late/pre-vacuolar compartment back to the recycling pathways. Our data suggest that ARF GEF- and retromer-dependent processes regulate PIN sorting to the vacuole in an antagonistic manner and illustrate instrumentalization of this mechanism for fine-tuning the auxin fluxes during gravitropic response.
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Cites
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,633
Self-citationEfflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R., & Jürgens, G. (2003) · Nature · doi:10.1038/nature02085 · Cited by 1,894
Self-citationRegulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
Self-citationLateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis
Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., & Palme, K. (2002) · Nature · doi:10.1038/415806a · Cited by 1,426
Self-citationAuxin transport inhibitors block PIN1 cycling and vesicle trafficking
Geldner, N., Friml, J., Stierhof, Y.-D., Jürgens, G., & Palme, K. (2001) · Nature · doi:10.1038/35096571 · Cited by 1,241
Self-citationGeldner, N., Anders, N., Wolters, H., Keicher, J., Kornberger, W., Muller, P., Delbarre, A., Ueda, T., Nakano, A., & Jürgens, G. (2003) · Cell · doi:10.1016/s0092-8674(03)00003-5 · Cited by 1,122
Cutler, S. R., Ehrhardt, D. W., Griffitts, J. S., & Somerville, C. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3718 · Cited by 985
PIN Proteins Perform a Rate-Limiting Function in Cellular Auxin Efflux
Petrášek, J., Mravec, J., Bouchard, R., Blakeslee, J. J., Abas, M., Seifertová, D., Wiśniewska, J., Tadele, Z., Kubeš, M., Čovanová, M., et al. (2006) · Science · doi:10.1126/science.1123542 · Cited by 921
Self-citationPolar PIN Localization Directs Auxin Flow in Plants
Wiśniewska, J., Xu, J., Seifertová, D., Brewer, P. B., Růžička, K., Blilou, I., Rouquié, D., Benková, E., Scheres, B., & Friml, J. (2006) · Science · doi:10.1126/science.1121356 · Cited by 882
Self-citationVacuolar H+-ATPase Activity Is Required for Endocytic and Secretory Trafficking in Arabidopsis
Dettmer, J., Hong-Hermesdorf, A., Stierhof, Y.-D., & Schumacher, K. (2006) · The Plant Cell · doi:10.1105/tpc.105.037978 · Cited by 852
Cited by
Temkin, P., Lauffer, B., Jäger, S., Cimermancic, P., Krogan, N. J., & von Zastrow, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2252 · Cited by 459
ABP1 Mediates Auxin Inhibition of Clathrin-Dependent Endocytosis in Arabidopsis
Robert, S., Kleine-Vehn, J., Barbez, E., Sauer, M., Paciorek, T., Baster, P., Vanneste, S., Zhang, J., Simon, S., Čovanová, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.027 · Cited by 420
Self-citationSorting nexins provide diversity for retromer-dependent trafficking events
Cullen, P. J., & Korswagen, H. C. (2012) · Nature Cell Biology · doi:10.1038/ncb2374 · Cited by 330
Root apex transition zone: a signalling–response nexus in the root
Baluška, F., Mancuso, S., Volkmann, D., & Barlow, P. W. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.04.007 · Cited by 286
Vandenbussche, F., Petrášek, J., Žádníková, P., Hoyerová, K., Pešek, B., Raz, V., Swarup, R., Bennett, M., Zažímalová, E., Benková, E., et al. (2010) · Development · doi:10.1242/dev.040790 · Cited by 272
Metadata
- Authors
- Kleine-Vehn, J., Leitner, J., Zwiewka, M., Sauer, M., Abas, L., Luschnig, C., & Friml, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-11-18
- Volume
- 105
- Issue
- 46
- Pages
- 17812-17817
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068588120
- Cited by
- 386
- References
- 47
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- green
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