The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Insulin levels control female germline stem cell maintenance via the niche in Drosophila
Open accessAbstract
Stem cell maintenance depends on local signals provided by specialized microenvironments, or niches, in which they reside. The potential role of systemic factors in stem cell maintenance, however, has remained largely unexplored. Here, we show that insulin signaling integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual regulation of cap cell number (via Notch signaling) and cap cell–GSC interaction (via E-cadherin) and that the normal process of GSC and niche cell loss that occurs with age can be suppressed by increased levels of insulin-like peptides. These results underscore the importance of systemic factors for the regulation of stem cell niches and, thereby, of stem cell numbers.
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Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis
Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268
Effects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal
Ryu, B.-Y., Orwig, K. E., Oatley, J. M., Avarbock, M. R., & Brinster, R. L. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0580 · Cited by 265
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Pan, L., Chen, S., Weng, C., Call, G., Zhu, D., Tang, H., Zhang, N., & Xie, T. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.09.010 · Cited by 211
Cited by
Reproduction–Immunity Trade-Offs in Insects
Schwenke, R. A., Lazzaro, B. P., & Wolfner, M. F. (2016) · Annual Review of Entomology · doi:10.1146/annurev-ento-010715-023924 · Cited by 632
When stem cells grow old: phenotypes and mechanisms of stem cell aging
Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331
Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
Partridge, L., Alic, N., Bjedov, I., & Piper, M. D. W. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.003 · Cited by 316
Emerging models and paradigms for stem cell ageing
Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-506 · Cited by 256
dFOXO‐independent effects of reduced insulin‐like signaling in Drosophila
Slack, C., Giannakou, M. E., Foley, A., Goss, M., & Partridge, L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00707.x · Cited by 204
Metadata
- Authors
- Hsu, H.-J., & Drummond-Barbosa, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-01-27
- Volume
- 106
- Issue
- 4
- Pages
- 1117-1121
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069290496
- Cited by
- 235
- References
- 4
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Hsu, H.-J., & Drummond-Barbosa, D. (2009). Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0809144106
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