Emerging models and paradigms for stem cell ageing
Open accessAbstract
Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.
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HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in telomere-related and other key biologic pathways.
“HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in these and other key biologic pathways (33–40).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [35]
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- Authors
- Jones, D. L., & Rando, T. A.
- Affiliations
- Salk Institute for Biological Studies (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Rando, Thomas A.
- Venue
- Nature Cell Biology
- Published
- 2011-05
- Volume
- 13
- Issue
- 5
- Pages
- 506-512
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC3257978
- OpenAlex
- W2060975420
- Cited by
- 256
- References
- 25
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 15 · 2022: 12 · 2021: 22 · 2020: 19 · 2019: 15 · 2018: 23 · 2017: 14 · 2016: 19 · 2015: 23 · 2014: 23 · 2013: 30 · 2012: 20
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DP1OD000392)
- National Institute on Aging (R37AG023806, R01AG023806, R37AG23806, R01AG028092)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056849)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- stem cell aging, invertebrate models, tissue homeostasis, tissue repair, stem cell self-renewal, aberrant differentiation
- MeSH terms
- Animals, Cell Differentiation, DNA Damage, Humans, Models, Biological, Stem Cells, Transcription, Genetic, Cellular Senescence, Apoptosis, Genomic Instability, Epigenesis, Genetic
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