The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
Open accessAbstract
A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways involved have often proved to sense nutrients and to match costly activities of organisms, such as growth, metabolism and reproduction, to nutrient status. For instance, the insulin/insulin-like growth factor and Target of Rapamycin signalling network has proved to play a function in ageing, from yeast to mammals, seemingly including humans. In the fruit fly Drosophila, altered activity of several components of this network can increase lifespan and improve locomotor and cardiac function during ageing. The fly brain, fat body (equivalent of mammalian liver and white adipose tissue) and the germ line are important in determination of lifespan, with considerable communication between different tissues. Cellular detoxification pathways, increased autophagy and altered protein synthesis have all been implicated in increased lifespan from reduced IIS/TOR activity, with the role of defence against oxidative stress unresolved. Reduced IIS/TOR signalling can alter or block the response of lifespan to dietary restriction. Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it.
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Citations
Cites
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Self-citationKenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
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Self-citationRegulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
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“…of both of these pathways, whether through genetic manipulation or chemical inhibition, can extend the lifespan in mice (reviewed in (Fontana et al., 2010; Kenyon, 2010), and can produce a remarkably broad-spectrum improvement in health during middle and old age (Selman et al., 2008, 2009).”
Self-citationInfluence of TOR kinase on lifespan in C. elegans
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster
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Self-citationDrosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
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Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822
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Cited by
Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956
Genetics of longevity in model organisms: debates and paradigm shifts
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Self-citationDrosophila as a model for ageing
Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.016 · Cited by 273
Self-citationLatitudinal clines: an evolutionary view on biological rhythms,
Hut, R. A., Paolucci, S., Dor, R., Kyriacou, C. P., & Daan, S. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.0433 · Cited by 241
Circadian autophagy drives iTRF-mediated longevity
Ulgherait, M., Midoun, A. M., Park, S. J., Gatto, J. A., Tener, S. J., Siewert, J., Klickstein, N., Canman, J. C., Ja, W. W., & Shirasu-Hiza, M. (2021) · Nature · doi:10.1038/s41586-021-03934-0 · Cited by 226
Metadata
- Authors
- Partridge, L., Alic, N., Bjedov, I., & Piper, M. D. W.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 46
- Issue
- 5
- Pages
- 376-381
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2128655116
- Cited by
- 316
- References
- 54
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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