The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates
Open accessAbstract
MicroRNAs (miRNAs) inhibit the translation of target mRNAs and affect, directly or indirectly, the expression of a large portion of the protein-coding genes. This study focuses on miRNAs that are expressed in the mouse cochlea and vestibule, the 2 inner ear compartments. A conditional knock-out mouse for Dicer1 demonstrated that miRNAs are crucial for postnatal survival of functional hair cells of the inner ear. We identified miRNAs that have a role in the vertebrate developing inner ear by combining miRNA transcriptome analysis, spatial and temporal expression patterns, and bioinformatics. Microarrays revealed similar miRNA profiles in newborn-mouse whole cochleae and vestibules, but different temporal and spatial expression patterns of six miRNAs (miR-15a, miR-18a, miR-30b, miR-99a, miR-182, and miR-199a) may reflect their roles. Two of these miRNAs, miR-15a-1 and miR-18a, were also shown to be crucial for zebrafish inner ear development and morphogenesis. To suggest putative target mRNAs whose translation may be inhibited by selected miRNAs, we combined bioinformatics-based predictions and mRNA expression data. Finally, we present indirect evidence that Slc12a2, Cldn12, and Bdnf mRNAs may be targets for miR-15a. Our data support the hypothesis that inner ear tissue differentiation and maintenance are regulated and controlled by conserved sets of cell-specific miRNAs in both mouse and zebrafish.
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Cites
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus
Davis, T. H., Cuellar, T. L., Koch, S. M., Barker, A. J., Harfe, B. D., McManus, M. T., & Ullian, E. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4815-07.2008 · Cited by 447
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice
Lewis, M. A., Quint, E., Glazier, A. M., Fuchs, H., De Angelis, M. H., Langford, C., van Dongen, S., Abreu-Goodger, C., Piipari, M., Redshaw, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.369 · Cited by 302
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Soukup, G. A., Fritzsch, B., Pierce, M. L., Weston, M. D., Jahan, I., McManus, M. T., & Harfe, B. D. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.01.037 · Cited by 125
Cited by
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF
Varendi, K., Kumar, A., Härma, M.-A., & Andressoo, J.-O. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1628-x · Cited by 170
MicroRNA-183 family members regulate sensorineural fates in the inner ear
Li, H., Kloosterman, W., & Fekete, D. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4948-09.2010 · Cited by 140
Self-citationmiR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells
Kuhn, S., Johnson, S. L., Furness, D. N., Chen, J., Ingham, N., Hilton, J. M., Steffes, G., Lewis, M. A., Zampini, V., Hackney, C. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016646108 · Cited by 114
MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a
Li, Y., Li, A., Wu, J., He, Y., Yu, H., Chai, R., & Li, H. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.246 · Cited by 46
Metadata
- Authors
- Friedman, L. M., Dror, A. A., Mor, E., Tenne, T., Toren, G., Satoh, T., Biesemeier, D. J., Shomron, N., Fekete, D. M., Hornstein, E., & Avraham, K. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-05-12
- Volume
- 106
- Issue
- 19
- Pages
- 7915-7920
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983611264
- Cited by
- 172
- References
- 8
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Friedman, L. M., Dror, A. A., Mor, E., Tenne, T., Toren, G., Satoh, T., Biesemeier, D. J., Shomron, N., Fekete, D. M., Hornstein, E., & Avraham, K. B. (2009). MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0812446106
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