miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF
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MiR-1 and miR-10b were previously reported to regulate BDNF, an important protein involved in synaptogenesis, memory, and learning.
“MiR-1 and miR-10b were previously reported to regulate BDNF (brain-derived neurotrophic factor) an important protein involved in synaptogenesis, memory, and leaning23.”
From A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase (2025) · cites this paper as [23]
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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 4,408 · cited 1× · see citing works
“The 3′ untranslated regions (3′UTRs) of mammalian genes contain highly conserved sequences [60] important in the regulation of translational efficiency, polyadenylation, and stability of the mRNA.”
BackgroundA Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works
The role of site accessibility in microRNA target recognition
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460 · see citing works
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965 · see citing works
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067 · see citing works
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819 · see citing works
Cardoso, A. L., Guedes, J. R., Pereira de Almeida, L., & Pedroso de Lima, M. C. (2012) · Immunology · doi:10.1111/j.1365-2567.2011.03514.x · Cited by 336 · see citing works
Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277 · see citing works
BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation
Mousavi, K., & Jasmin, B. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5398-05.2006 · Cited by 210 · see citing works
Brain‐derived neurotrophic factor expression is repressed during myogenic differentiation by miR‐206
Miura, P., Amirouche, A., Clow, C., Bélanger, G., & Jasmin, B. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07583.x · Cited by 92 · see citing works
Flagged first, then by citations
Research works printed but not linked: 58
- [1]Abidin I Eysel UT Lessmann V Mittmann T Impaired GABAergic inhibition in the visual cortex of brain-derived neurotrophic factor heterozygous knockout mice J Physiol 2008 586 1885 1901 10.1113/jphysiol.2007.148627 18238806 PMC2375720 · DOI
- [2]Abidin I Kohler T Weiler E Zoidl G Eysel UT Lessmann V Mittmann T Reduced presynaptic efficiency of excitatory synaptic transmission impairs LTP in the visual cortex of BDNF-heterozygous mice Eur J Neurosci 2006 24 3519 3531 10.1111/j.1460-9568.2006.05242.x 17229100 · DOI
- [3]An JJ Gharami K Liao GY Woo NH Lau AG Vanevski F Torre ER Jones KR Feng Y Lu B Xu B Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons Cell 2008 134 175 187 10.1016/j.cell.2008.05.045 18614020 PMC2527207 · DOI
- [4]Arvey A Larsson E Sander C Leslie CS Marks DS Target mRNA abundance dilutes microRNA and siRNA activity Mol Syst Biol 2010 6 363 10.1038/msb.2010.24 20404830 PMC2872614 · DOI
- [5]Baquet ZC Bickford PC Jones KR Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta J Neurosci 2005 25 6251 6259 10.1523/JNEUROSCI.4601-04.2005 15987955 PMC6725062 · DOI
- [6]Barrett LW Fletcher S Wilton SD Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements Cell Mol Life Sci 2012 69 3613 3634 10.1007/s00018-012-0990-9 22538991 PMC3474909 · DOI
- [7]Bartel DP MicroRNAs: genomics, biogenesis, mechanism, and function Cell 2004 116 281 297 10.1016/S0092-8674(04)00045-5 14744438 · DOI
- [8]Calabrese F Molteni R Maj PF Cattaneo A Gennarelli M Racagni G Riva MA Chronic duloxetine treatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein Neuropsychopharmacology 2007 32 2351 2359 10.1038/sj.npp.1301360 17327885 · DOI
- [10]Castren E Berninger B Leingartner A Lindholm D Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity Prog Brain Res 1998 117 57 64 10.1016/S0079-6123(08)64007-8 9932400 · DOI
- [11]Chan JP Unger TJ Byrnes J Rios M Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice Neuroscience 2006 142 49 58 10.1016/j.neuroscience.2006.06.002 16844311 · DOI
- [12]Chen JF Mandel EM Thomson JM Wu Q Callis TE Hammond SM Conlon FL Wang DZ The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation Nat Genet 2006 38 228 233 10.1038/ng1725 16380711 PMC2538576 · DOI
- [13]Clow C Jasmin BJ Brain-derived neurotrophic factor regulates satellite cell differentiation and skeletal muscle regeneration Mol Biol Cell 2010 21 2182 2190 10.1091/mbc.E10-02-0154 20427568 PMC2893983 · DOI
- [15]Dluzen DE Anderson LI McDermott JL Kucera J Walro JM Striatal dopamine output is compromised within ± BDNF mice Synapse 2002 43 112 117 10.1002/syn.10027 11754489 · DOI
- [16]Donovan MJ Lin MI Wiegn P Ringstedt T Kraemer R Hahn R Wang S Ibanez CF Rafii S Hempstead BL Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization Development 2000 127 4531 4540 11023857
- [17]Dunn KC Aotaki-Keen AE Putkey FR Hjelmeland LM ARPE-19, a human retinal pigment epithelial cell line with differentiated properties Exp Eye Res 1996 62 155 169 10.1006/exer.1996.0020 8698076 · DOI
- [18]Ebert MS Neilson JR Sharp PA MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells Nat Methods 2007 4 721 726 10.1038/nmeth1079 17694064 PMC3857099 · DOI · Paper page
- [19]Egan MF Kojima M Callicott JH Goldberg TE Kolachana BS Bertolino A Zaitsev E Gold B Goldman D Dean M Lu B Weinberger DR The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 2003 112 257 269 10.1016/S0092-8674(03)00035-7 12553913 · DOI · Paper page
- [20]Ernfors P Ibanez CF Ebendal T Olson L Persson H Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain Proc Natl Acad Sci USA 1990 87 5454 5458 10.1073/pnas.87.14.5454 2164684 PMC54343 · DOI · Paper page
- [23]Ferrer I Goutan E Marin C Rey MJ Ribalta T Brain-derived neurotrophic factor in Huntington disease Brain Res 2000 866 257 261 10.1016/S0006-8993(00)02237-X 10825501 · DOI
- [24]Filipowicz W Bhattacharyya SN Sonenberg N Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008 9 102 114 10.1038/nrg2290 18197166 · DOI
- [25]Friedman LM Dror AA Mor E Tenne T Toren G Satoh T Biesemeier DJ Shomron N Fekete DM Hornstein E Avraham KB MicroRNAs are essential for development and function of inner ear hair cells in vertebrates Proc Natl Acad Sci USA 2009 106 7915 7920 10.1073/pnas.0812446106 19416898 PMC2683084 · DOI
- [26]Fukuchi M Tsuda M Involvement of the 3′-untranslated region of the brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization J Neurochem 2010 115 1222 1233 10.1111/j.1471-4159.2010.07016.x 20874756 · DOI
- [27]Funakoshi H Frisen J Barbany G Timmusk T Zachrisson O Verge VM Persson H Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve J Cell Biol 1993 123 455 465 10.1083/jcb.123.2.455 8408225 PMC2119843 · DOI
- [28]Gentner B Schira G Giustacchini A Amendola M Brown BD Ponzoni M Naldini L Stable knockdown of microRNA in vivo by lentiviral vectors Nat Methods 2009 6 63 66 10.1038/nmeth.1277 19043411 · DOI
- [29]Grimson A Farh KK Johnston WK Garrett-Engele P Lim LP Bartel DP MicroRNA targeting specificity in mammals: determinants beyond seed pairing Mol Cell 2007 27 91 105 10.1016/j.molcel.2007.06.017 17612493 PMC3800283 · DOI · Paper page
- [31]Hofer M Pagliusi SR Hohn A Leibrock J Barde YA Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain EMBO J 1990 9 2459 2464 2369898 PMC552273
- [32]Huang EJ Reichardt LF Neurotrophins: roles in neuronal development and function Annu Rev Neurosci 2001 24 677 736 10.1146/annurev.neuro.24.1.677 11520916 PMC2758233 · DOI · Paper page
- [33]John B Enright AJ Aravin A Tuschl T Sander C Marks DS Human MicroRNA targets PLoS Biol 2004 2 e363 10.1371/journal.pbio.0020363 15502875 PMC521178 · DOI · Paper page
- [35]Kim HK Lee YS Sivaprasad U Malhotra A Dutta A Muscle-specific microRNA miR-206 promotes muscle differentiation J Cell Biol 2006 174 677 687 10.1083/jcb.200603008 16923828 PMC2064311 · DOI
- [36]Konopka W Kiryk A Novak M Herwerth M Parkitna JR Wawrzyniak M Kowarsch A Michaluk P Dzwonek J Arnsperger T Wilczynski G Merkenschlager M Theis FJ Kohr G Kaczmarek L Schutz G MicroRNA loss enhances learning and memory in mice J Neurosci 2010 30 14835 14842 10.1523/JNEUROSCI.3030-10.2010 21048142 PMC6633640 · DOI · Paper page
- [37]Korte M Carroll P Wolf E Brem G Thoenen H Bonhoeffer T Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor Proc Natl Acad Sci USA 1995 92 8856 8860 10.1073/pnas.92.19.8856 7568031 PMC41066 · DOI · Paper page
- [38]Krek A Grun D Poy MN Wolf R Rosenberg L Epstein EJ MacMenamin P da Piedade I Gunsalus KC Stoffel M Rajewsky N Combinatorial microRNA target predictions Nat Genet 2005 37 495 500 10.1038/ng1536 15806104 · DOI · Paper page
- [39]Lagos-Quintana M Rauhut R Yalcin A Meyer J Lendeckel W Tuschl T Identification of tissue-specific microRNAs from mouse Curr Biol 2002 12 735 739 10.1016/S0960-9822(02)00809-6 12007417 · DOI · Paper page
- [41]Lau AG Irier HA Gu J Tian D Ku L Liu G Xia M Fritsch B Zheng JQ Dingledine R Xu B Lu B Feng Y Distinct 3′UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF) Proc Natl Acad Sci USA 2010 107 15945 15950 10.1073/pnas.1002929107 20733072 PMC2936648 · DOI
- [42]Lee ST Chu K Jung KH Kim JH Huh JY Yoon H Park DK Lim JY Kim JM Jeon D Ryu H Lee SK Kim M Roh JK miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model Ann Neurol 2012 72 269 277 10.1002/ana.23588 22926857 · DOI · Paper page
- [43]Lewis BP Burge CB Bartel DP Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 2005 120 15 20 10.1016/j.cell.2004.12.035 15652477 · DOI · Paper page
- [44]Lu B BDNF and activity-dependent synaptic modulation Learn Mem 2003 10 86 98 10.1101/lm.54603 12663747 PMC5479144 · DOI · Paper page
- [45]Lyons WE Mamounas LA Ricaurte GA Coppola V Reid SW Bora SH Wihler C Koliatsos VE Tessarollo L Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities Proc Natl Acad Sci USA 1999 96 15239 15244 10.1073/pnas.96.26.15239 10611369 PMC24804 · DOI
- [46]Mellios N Huang HS Grigorenko A Rogaev E Akbarian S A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex Hum Mol Genet 2008 17 3030 3042 10.1093/hmg/ddn201 18632683 PMC2722882 · DOI · Paper page
- [48]Moore MJ From birth to death: the complex lives of eukaryotic mRNAs Science 2005 309 1514 1518 10.1126/science.1111443 16141059 · DOI
- [50]Nakajo Y Miyamoto S Nakano Y Xue JH Hori T Yanamoto H Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory Brain Res 2008 1241 103 109 10.1016/j.brainres.2008.08.080 18801341 · DOI · Paper page
- [51]Park H Poo MM Neurotrophin regulation of neural circuit development and function Nat Rev Neurosci 2013 14 7 23 10.1038/nrn3379 23254191 · DOI · Paper page
- [52]Peltier HJ Latham GJ Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues RNA 2008 14 844 852 10.1261/rna.939908 18375788 PMC2327352 · DOI · Paper page
- [53]Poliseno L Salmena L Zhang J Carver B Haveman WJ Pandolfi PP A coding-independent function of gene and pseudogene mRNAs regulates tumour biology Nature 2010 465 1033 1038 10.1038/nature09144 20577206 PMC3206313 · DOI
- [54]Radzikinas K Aven L Jiang Z Tran T Paez-Cortez J Boppidi K Lu J Fine A Ai X A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle J Neurosci 2011 31 15407 15415 10.1523/JNEUROSCI.2745-11.2011 22031887 PMC3222097 · DOI
- [55]Rios M Fan G Fekete C Kelly J Bates B Kuehn R Lechan RM Jaenisch R Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity Mol Endocrinol 2001 15 1748 1757 10.1210/mend.15.10.0706 11579207 · DOI
- [56]Saetrom P Heale BS Snove O Jr Aagaard L Alluin J Rossi JJ Distance constraints between microRNA target sites dictate efficacy and cooperativity Nucleic Acids Res 2007 35 2333 2342 10.1093/nar/gkm133 17389647 PMC1874663 · DOI
- [57]Salmena L Poliseno L Tay Y Kats L Pandolfi PP A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 2011 146 353 358 10.1016/j.cell.2011.07.014 21802130 PMC3235919 · DOI · Paper page
- [58]Sandberg R Neilson JR Sarma A Sharp PA Burge CB Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites Science 2008 320 1643 1647 10.1126/science.1155390 18566288 PMC2587246 · DOI · Paper page
- [61]Timmusk T Palm K Metsis M Reintam T Paalme V Saarma M Persson H Multiple promoters direct tissue-specific expression of the rat BDNF gene Neuron 1993 10 475 489 10.1016/0896-6273(93)90335-O 8461137 · DOI · Paper page
- [62]Timmusk T Persson H Metsis M Analysis of transcriptional initiation and translatability of brain-derived neurotrophic factor mRNAs in the rat brain Neurosci Lett 1994 177 27 31 10.1016/0304-3940(94)90036-1 7824176 · DOI
- [63]Trang T Beggs S Salter MW Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain Neuron Glia Biology 2011 7 99 108 10.1017/S1740925X12000087 22613083 PMC3748035 · DOI · Paper page
- [64]Tyler WJ Alonso M Bramham CR Pozzo-Miller LD From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning Learn Mem 2002 9 224 237 10.1101/lm.51202 12359832 PMC2806479 · DOI
- [65]Yaffe D Saxel O Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle Nature 1977 270 725 727 10.1038/270725a0 563524 · DOI
- [66]Yajima Y Narita M Usui A Kaneko C Miyatake M Yamaguchi T Tamaki H Wachi H Seyama Y Suzuki T Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice J Neurochem 2005 93 584 594 10.1111/j.1471-4159.2005.03045.x 15836617 · DOI
- [67]Zhao Y Ransom JF Li A Vedantham V von Drehle M Muth AN Tsuchihashi T McManus MT Schwartz RJ Srivastava D Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2 Cell 2007 129 303 317 10.1016/j.cell.2007.03.030 17397913 · DOI
- [68]Zhao Y Samal E Srivastava D Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis Nature 2005 436 214 220 10.1038/nature03817 15951802 · DOI
- [69]Zuccato C Ciammola A Rigamonti D Leavitt BR Goffredo D Conti L MacDonald ME Friedlander RM Silani V Hayden MR Timmusk T Sipione S Cattaneo E Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease Science 2001 293 493 498 10.1126/science.1059581 11408619 · DOI
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- Authors
- Varendi, K., Kumar, A., Härma, M.-A., & Andressoo, J.-O.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2014-05-08
- Volume
- 71
- Issue
- 22
- Pages
- 4443-4456
- ISSN
- 1420-682X
- 1420-9071
- PMC
- PMC4207943
- Cited by
- 144
- References
- 11
- Language
- en
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