The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus
Open accessAbstract
Hepatitis C virus (HCV) infects nearly 3% of the population of the world and is a major cause of liver disease. However, the mechanism whereby the virus targets the liver for infection remains unknown, because none of the putative cellular receptors for HCV are both expressed specifically in the liver and capable of binding HCV envelope glycoproteins. Liver/lymph node-specific intercellular adhesion molecule-3-grabbing integrin (L-SIGN) is a calcium-dependent lectin expressed on endothelial cells of liver and lymph nodes. Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), a homologous molecule expressed on dendritic cells, binds HIV and promotes infection. By using a virus-binding assay, we demonstrate that L-SIGN and DC-SIGN specifically bind naturally occurring HCV present in the sera of infected individuals. Further studies demonstrate that binding is mediated by the HCV envelope glycoprotein E2 and is blocked by specific inhibitors, including mannan, calcium chelators, and Abs to the lectin domain of the SIGN molecules. Thus, L-SIGN represents a liver-specific receptor for HCV, and L-SIGN and DC-SIGN may play important roles in HCV infection and immunity.
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Cites
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
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DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
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Binding of Hepatitis C Virus to CD81
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The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
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Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
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C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans
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Cited by
Bartosch, B., Vitelli, A., Granier, C., Goujon, C., Dubuisson, J., Pascale, S., Scarselli, E., Cortese, R., Nicosia, A., & Cosset, F.-L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305289200 · Cited by 631
Living in the liver: hepatic infections
Protzer, U., Maini, M. K., & Knolle, P. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3169 · Cited by 560
Self- and nonself-recognition by C-type lectins on dendritic cells
Geijtenbeek, T. B. H., van Vliet, S. J., Engering, A., 't Hart, B. A., & van Kooyk, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104558 · Cited by 503
Koutsoudakis, G., Kaul, A., Steinmann, E., Kallis, S., Lohmann, V., Pietschmann, T., & Bartenschlager, R. (2006) · Journal of Virology · doi:10.1128/jvi.02460-05 · Cited by 414
Marzi, A., Gramberg, T., Simmons, G., Möller, P., Rennekamp, A. J., Krumbiegel, M., Geier, M., Eisemann, J., Turza, N., Saunier, B., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.21.12090-12095.2004 · Cited by 377
Metadata
- Authors
- Gardner, J. P., Durso, R. J., Arrigale, R. R., Donovan, G. P., Maddon, P. J., Dragic, T., & Olson, W. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-03
- Volume
- 100
- Issue
- 8
- Pages
- 4498-4503
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052588752
- Cited by
- 306
- References
- 40
- FWCI
- 21.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Gardner, J. P., Durso, R. J., Arrigale, R. R., Donovan, G. P., Maddon, P. J., Dragic, T., & Olson, W. C. (2003). L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0831128100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
