The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rapid detection and profiling of cancer cells in fine-needle aspirates
Open accessAbstract
There is a growing need for fast, highly sensitive and quantitative technologies to detect and profile unaltered cells in biological samples. Technologies in current clinical use are often time consuming, expensive, or require considerable sample sizes. Here, we report a diagnostic magnetic resonance (DMR) sensor that combines a miniaturized NMR probe with targeted magnetic nanoparticles for detection and molecular profiling of cancer cells. The sensor measures the transverse relaxation rate of water molecules in biological samples in which target cells of interest are labeled with magnetic nanoparticles. We achieved remarkable sensitivity improvements over our prior DMR prototypes by synthesizing new nanoparticles with higher transverse relaxivity and by optimizing assay protocols. We detected as few as 2 cancer cells in 1-μL sample volumes of unprocessed fine-needle aspirates of tumors and profiled the expression of several cellular markers in <15 min.
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Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Cited by
Tassa, C., Shaw, S. Y., & Weissleder, R. (2011) · Accounts of Chemical Research · doi:10.1021/ar200084x · Cited by 653
Self-citationAptamers from Cell-Based Selection for Bioanalytical Applications
Tan, W., Donovan, M. J., & Jiang, J. (2013) · Chemical Reviews · doi:10.1021/cr300468w · Cited by 649
Conde, J., Dias, J. T., Grazú, V., Moros, M., Baptista, P. V., & de la Fuente, J. M. (2014) · Frontiers in Chemistry · doi:10.3389/fchem.2014.00048 · Cited by 425
Liu, H.-L., Hua, M.-Y., Yang, H.-W., Huang, C.-Y., Chu, P.-C., Wu, J.-S., Tseng, I.-C., Wang, J.-J., Yen, T.-C., Chen, P.-Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003388107 · Cited by 395
New forms of superparamagnetic nanoparticles for biomedical applications
Xu, C., & Sun, S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.008 · Cited by 349
Metadata
- Authors
- Lee, H., Yoon, T.-J., Figueiredo, J.-L., Swirski, F. K., & Weissleder, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-07-28
- Volume
- 106
- Issue
- 30
- Pages
- 12459-12464
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059989708
- Cited by
- 187
- References
- 3
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, H., Yoon, T.-J., Figueiredo, J.-L., Swirski, F. K., & Weissleder, R. (2009). Rapid detection and profiling of cancer cells in fine-needle aspirates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0902365106
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