Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy
Open accessAbstract
Advances in our understanding of the genetic basis of disease susceptibility coupled with prominent successes for molecular targeted therapies have resulted in an emerging strategy of personalized medicine. This approach envisions risk stratification and therapeutic selection based on an individual's genetic makeup and physiologic state (the latter assessed through cellular or molecular phenotypes). Molecularly targeted nanoparticles can play a key role in this vision through noninvasive assessments of molecular processes and specific cell populations in vivo, sensitive molecular diagnostics, and targeted delivery of therapeutics. A superparamagnetic iron oxide nanoparticle with a cross-linked dextran coating, or CLIO, is a powerful and illustrative nanoparticle platform for these applications. These structures and their derivatives support diagnostic imaging by magnetic resonance (MRI), optical, and positron emission tomography (PET) modalities and constitute a versatile platform for conjugation to targeting ligands. A variety of conjugation methods exist to couple the dextran surface to different functional groups; in addition, a robust bioorthogonal [4 + 2] cycloaddition reaction between 1,2,4,5-tetrazene (Tz) and trans-cyclooctene (TCO) can conjugate nanoparticles to targeting ligands or label pretargeted cells. The ready availability of conjugation methods has given rise to the synthesis of libraries of small molecule modified nanoparticles, which can then be screened for nanoparticles with specificity for a specific cell type. Since most nanoparticles display their targeting ligands in a multivalent manner, a detailed understanding of the kinetics and affinity of a nanoparticle's interaction with its target (as determined by surface plasmon resonance) can yield functionally important insights into nanoparticle design. In this Account, we review applications of the CLIO platform in several areas relevant to the mission of personalized medicine. We demonstrate rapid and highly sensitive molecular profiling of cancer markers ex vivo, as part of detailed, individualized molecular phenotyping. The CLIO platform also facilitates targeted magnetic resonance and combined modality imaging (such as MR/PET/fluorescence/CT) to enable multiplexed measurement of molecular phenotypes in vivo for early diagnosis and disease classification. Finally, the targeted delivery of a photodynamic therapy agent as part of a theranostic nanoparticle successfully increased local cell toxicity and minimized systemic side effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
While dextran has no direct cytotoxic effects, degradation of the dextran shell may influence certain cellular processes.
“It has to be kept in mind in this regard that while dextran has no direct cytotoxic effects, the degradation of the dextran shell may influence certain cellular processes [30, 65, 86, 87].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [65]
Several other variations of this probe have been developed, including for hybrid PET-optical or trimodal imaging.
“Several other variations of this probe have been developed, including probes used for hybrid PET–optical imaging or even trimodal imaging149.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [149]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076 · see citing works
Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Sun, S., Zeng, H., Robinson, D., Raoux, S., Rice, P. M., Wang, S. X., & Li, G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0380852 · Cited by 3,441 · see citing works
Hyeon, T., Lee, S. S., Park, J., Chung, Y., & Na, H. B. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016812s · Cited by 2,040 · see citing works
The role of porphyrin chemistry in tumor imaging and photodynamic therapy
Ethirajan, M., Chen, Y., Joshi, P., & Pandey, R. K. (2010) · Chemical Society Reviews · doi:10.1039/b915149b · Cited by 2,038 · see citing works
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022749 · Cited by 1,971 · see citing works
Self-citationSynthesis of Monodisperse Spherical Nanocrystals
Park, J., Joo, J. S., Kwon, S. G., Jang, Y., & Hyeon, T. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200603148 · Cited by 1,948 · see citing works
Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity
Blackman, M. L., Royzen, M., & Fox, J. M. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8053805 · Cited by 1,691 · see citing works
Weissleder, R. (2006) · Science · doi:10.1126/science.1125949 · Cited by 1,107 · see citing works
Self-citationSuperparamagnetic iron oxide: pharmacokinetics and toxicity
Weissleder, R., Stark, D., Engelstad, B. L., Bacon, B., Compton, C. C., White, D., Jacobs, P. M., & Lewis, J. M. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.1.167 · Cited by 1,045 · see citing works
Self-citationCell-specific targeting of nanoparticles by multivalent attachment of small molecules
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T., & Josephson, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1159 · Cited by 898 · see citing works
Self-citationMultifunctional magnetic nanoparticles for targeted imaging and therapy
MCCARTHY, J., & WEISSLEDER, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.014 · Cited by 892 · see citing works
Self-citationMagnetic relaxation switches capable of sensing molecular interactions
Pérez, J. M. S., Josephson, L., O'Loughlin, T., Högemann, D., & Weissleder, R. (2002) · Nature Biotechnology · doi:10.1038/nbt720 · Cited by 889 · see citing works
Self-citationHigh-Efficiency Intracellular Magnetic Labeling with Novel Superparamagnetic-Tat Peptide Conjugates
Josephson, L., Tung, C., Moore, A. V., & Weissleder, R. (1999) · Bioconjugate Chemistry · doi:10.1021/bc980125h · Cited by 882 · see citing works
Self-citationTetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging
Devaraj, N. K., Weissleder, R., & Hilderbrand, S. A. (2008) · Bioconjugate Chemistry · doi:10.1021/bc8004446 · Cited by 859 · see citing works
Self-citationIn vivo magnetic resonance imaging of transgene expression
Weissleder, R., Moore, A. V., Mahmood, U., Bhorade, R. M., Benveniste, H., Chiocca, E. A., & Basilion, J. P. (2000) · Nature Medicine · doi:10.1038/73219 · Cited by 776 · see citing works
Self-citationChip–NMR biosensor for detection and molecular analysis of cells
Lee, H., Sun, E., Ham, D., & Weissleder, R. (2008) · Nature Medicine · doi:10.1038/nm.1711 · Cited by 621 · see citing works
Self-citationSurface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy
Kievit, F. M., & Zhang, M. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000277 · Cited by 606 · see citing works
Nahrendorf, M., Jaffer, F. A., Kelly, K. A., Sosnovik, D. E., Aikawa, E., Libby, P., & Weissleder, R. (2006) · Circulation · doi:10.1161/circulationaha.106.646380 · Cited by 602 · see citing works
Self-citationMagnetic nanoparticle biosensors
Haun, J. B., Yoon, T., Lee, H., & Weissleder, R. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.84 · Cited by 554 · see citing works
Self-citationMonocrystalline iron oxide nanocompounds (MION): Physicochemical properties
Shen, T. T., Weissleder, R., Papisov, M. I., Bogdanov, A. A., Jr., & Brady, T. J. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290504 · Cited by 496 · see citing works
Self-citationBioorthogonal Turn‐On Probes for Imaging Small Molecules inside Living Cells
Devaraj, N. K., Hilderbrand, S. A., Upadhyay, R., et al. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906120 · Cited by 457 · see citing works
Long-circulating iron oxides for MR imaging
Weissleder, R., Bogdanov, A. A., Jr., Neuwelt, E. A., & Papisov, M. I. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00033-4 · Cited by 399 · see citing works
Self-citationDevaraj, N. K., Upadhyay, R., Haun, J. B., Hilderbrand, S. A., & Weissleder, R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200903233 · Cited by 380 · see citing works
Self-citationMolecular Imaging in the Clinical Arena
Jaffer, F. A. (2005) · JAMA · doi:10.1001/jama.293.7.855 · Cited by 364 · see citing works
Santra, S., Kaittanis, C., Grimm, J., & Perez, J. M. (2009) · Small · doi:10.1002/smll.200900389 · Cited by 353 · see citing works
Haun, J. B., Devaraj, N. K., Hilderbrand, S. A., Lee, H., & Weissleder, R. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.148 · Cited by 344 · see citing works
Self-citationUse of magnetic nanoparticles as nanosensors to probe for molecular interactions
Perez, J. M., Josephson, L., & Weissleder, R. (2004) · ChemBioChem · doi:10.1002/cbic.200300730 · Cited by 268 · see citing works
Self-citation18 F Labeled Nanoparticles for in Vivo PET-CT Imaging
Devaraj, N. K., Keliher, E. J., Thurber, G. M., Nahrendorf, M., & Weissleder, R. (2009) · Bioconjugate Chemistry · doi:10.1021/bc8004649 · Cited by 243 · see citing works
Self-citationMagnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto‐optical nanoparticle
Sosnovik, D. E., Schellenberger, E., Nahrendorf, M., Novikov, M. S., Matsui, T., Dai, G., Reynolds, F., Grazette, L., Rosenzweig, A., Weissleder, R., et al. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20617 · Cited by 242 · see citing works
Self-citationTargeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma
Kelly, K. A., Bardeesy, N. M., Anbazhagan, R., Gurumurthy, S., Berger, J. H., Alencar, H., DePinho, R. A., Mahmood, U., & Weissleder, R. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050085 · Cited by 242 · see citing works
Self-citationMagnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications
Sosnovik, D. E., Nahrendorf, M., & Weissleder, R. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0710-7 · Cited by 229 · see citing works
Self-citationEmerging concepts in molecular MRI
Sosnovik, D. E., & Weissleder, R. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.11.001 · Cited by 225 · see citing works
Self-citationFactors determining antibody distribution in tumors
Thurber, G. M., Schmidt, M., & Wittrup, K. D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.11.004 · Cited by 224 · see citing works
Hybrid PET-optical imaging using targeted probes
Nahrendorf, M., Keliher, E. J., Marinelli, B. S., Waterman, P. R., Feruglio, P. F., Fexon, L., Pivovarov, M., Świrski, F. K., Pittet, M. J., Vinegoni, C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915163107 · Cited by 222 · see citing works
Self-citationSpikes, J. D. (1990) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(90)85096-f · Cited by 219 · see citing works
One-Step, Nanoparticle-Mediated Bacterial Detection with Magnetic Relaxation
Kaittanis, C., Naser, S. A., & Perez, J. M. (2006) · Nano Letters · doi:10.1021/nl062553z · Cited by 214 · see citing works
Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples
Haun, J. B., Castro, C. M., Wang, R., Peterson, V. M., Marinelli, B. S., Lee, H., & Weissleder, R. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002048 · Cited by 214 · see citing works
Self-citationHan, H., Devaraj, N. K., Lee, J., Hilderbrand, S. A., Weissleder, R., & Bawendi, M. G. (2010) · Journal of the American Chemical Society · doi:10.1021/ja101677r · Cited by 211 · see citing works
Self-citationMagneto/Optical Annexin V, a Multimodal Protein
Schellenberger, E. A., Sosnovik, D. E., Weissleder, R., & Josephson, L. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049905i · Cited by 207 · see citing works
Self-citationBinding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles
Tassa, C., Duffner, J. L., Lewis, T. A., Weissleder, R., Schreiber, S. L., Koehler, A. N., & Shaw, S. Y. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900438a · Cited by 202 · see citing works
Self-citationUltrasensitive Detection of Bacteria Using Core–Shell Nanoparticles and an NMR‐Filter System
Lee, H., Yoon, T., & Weissleder, R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901791 · Cited by 196 · see citing works
Self-citationRapid detection and profiling of cancer cells in fine-needle aspirates
Lee, H., Yoon, T., Figueiredo, J., Świrski, F. K., & Weissleder, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902365106 · Cited by 187 · see citing works
Self-citationImaging inflammation of the pancreatic islets in type 1 diabetes
Denis, M. C., Mahmood, U., Benoist, C. O., Mathis, D. J., & Weissleder, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404307101 · Cited by 176 · see citing works
Self-citationCrosslinked Iron Oxides (CLIO)
Wunderbaldinger, P., Josephson, L., & Weissleder, R. (2002) · Academic Radiology · doi:10.1016/s1076-6332(03)80210-6 · Cited by 169 · see citing works
Self-citationMorishige, K., Kacher, D. F., Libby, P., Josephson, L., Ganz, P., Weissleder, R., & Aikawa, M. (2010) · Circulation · doi:10.1161/circulationaha.109.891804 · Cited by 168 · see citing works
Self-citationNovel Nanosensors for Rapid Analysis of Telomerase Activity
Grimm, J., Pérez, J. M. S., Josephson, L., & Weissleder, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2798 · Cited by 166 · see citing works
Self-citationA Macrophage‐Targeted Theranostic Nanoparticle for Biomedical Applications
McCarthy, J. R., Jaffer, F. A., & Weissleder, R. (2006) · Small · doi:10.1002/smll.200600139 · Cited by 158 · see citing works
Self-citationImaging Pancreatic Cancer with a Peptide−Nanoparticle Conjugate Targeted to Normal Pancreas
Montet, X., Weissleder, R., & Josephson, L. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060035+ · Cited by 151 · see citing works
Self-citationMcCarthy, J. R., Korngold, E., Weissleder, R., & Jaffer, F. A. (2010) · Small · doi:10.1002/smll.201000596 · Cited by 151 · see citing works
Self-citationCellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
Jaffer, F. A., Nahrendorf, M., Sosnovik, D. E., Kelly, K. A., Aikawa, E. R., & Weissleder, R. (2006) · Molecular Imaging · doi:10.2310/7290.2006.00009 · Cited by 149 · see citing works
Self-citationMolecular Imaging: Principles and Practice
Kim, E. E. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.092270 · Cited by 144 · see citing works
Nahrendorf, M., Keliher, E. J., Marinelli, B. S., Leuschner, F., Robbins, C. S., Gerszten, R. E., Pittet, M. J., Świrski, F. K., & Weissleder, R. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221499 · Cited by 140 · see citing works
Self-citationHigh Throughput Magnetic Resonance Imaging for Evaluating Targeted Nanoparticle Probes
Högemann, D., Ntziachristos, V., Josephson, L., & Weissleder, R. (2002) · Bioconjugate Chemistry · doi:10.1021/bc015549h · Cited by 136 · see citing works
Self-citationKorosoglou, G., Weiss, R. G., Kedziorek, D., Walczak, P., Gilson, W. D., Schär, M., Sosnovik, D. E., Kraitchman, D. L., Boston, R. C., Bulte, J. W. M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.03.063 · Cited by 118 · see citing works
Self-citationLeimgruber, A., Berger, C., Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Waterman, P. R., de Figueiredo, J. L., Köhler, R. H., Elpek, N. M., Mempel, T. R., et al. (2009) · Neoplasia · doi:10.1593/neo.09356 · Cited by 115 · see citing works
Self-citationReiner, T., Keliher, E. J., Earley, S., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006579 · Cited by 102 · see citing works
Kaittanis, C., Santra, S., & Pérez, J. M. S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9041077 · Cited by 101 · see citing works
Sosnovik, D. E., Garanger, É., Aikawa, E. R., Nahrendorf, M., Figueiredo, J., Dai, G., Reynolds, F., Rosenzweig, A., Weissleder, R., & Josephson, L. (2009) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.109.859678 · Cited by 99 · see citing works
Self-citationUtility of a New Bolus-injectable Nanoparticle for Clinical Cancer Staging
Harisinghani, M. G., Ross, R. W., Guimarães, A. R., & Weissleder, R. (2007) · Neoplasia · doi:10.1593/neo.07940 · Cited by 97 · see citing works
Self-citationKaittanis, C., Nath, S., & Perez, J. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003253 · Cited by 93 · see citing works
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
Turvey, S. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25048 · Cited by 92 · see citing works
High‐Yielding, Two‐Step 18F Labeling Strategy for 18F‐PARP1 Inhibitors
Keliher, E. J., Reiner, T., Turetsky, A., Hilderbrand, S. A., & Weissleder, R. (2011) · ChemMedChem · doi:10.1002/cmdc.201000426 · Cited by 78 · see citing works
Self-citationHaun, J. B., Devaraj, N. K., Marinelli, B. S., Lee, H., & Weissleder, R. (2011) · ACS Nano · doi:10.1021/nn200333m · Cited by 71 · see citing works
Self-citationCarboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications
Liong, M., Shao, H., Haun, J. B., Lee, H., & Weissleder, R. (2010) · Advanced Materials · doi:10.1002/adma.201002219 · Cited by 68 · see citing works
Self-citationBioorthogonal Small‐Molecule Ligands for PARP1 Imaging in Living Cells
Reiner, T., Earley, S., Turetsky, A., & Weissleder, R. (2010) · ChemBioChem · doi:10.1002/cbic.201000477 · Cited by 58 · see citing works
Self-citationSosnovik, D. E., Nahrendorf, M., Panizzi, P. R., Matsui, T., Aïkawa, E., Dai, G., Li, L., Reynolds, F., Dorn, G. W., Weissleder, R., et al. (2009) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.109.863779 · Cited by 56 · see citing works
Self-citationIntegrated Nanosensors to Determine Levels and Functional Activity of Human Telomerase
Pérez, J. M. S., Grimm, J., Josephson, L., & Weissleder, R. (2008) · Neoplasia · doi:10.1593/neo.08350 · Cited by 39 · see citing works
Self-citationMRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition
Guimarães, A. R., Ross, R. W., Figuereido, J. L., Waterman, P. R., & Weissleder, R. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0357-2 · Cited by 23 · see citing works
Self-citationGuimarães, A. R., Rakhlin, E. Y., Weissleder, R., et al. (2008) · Pancreas · doi:10.1097/mpa.0b013e31817c5113 · Cited by 23 · see citing works
Self-citationPositive contrast MR‐lymphography using inversion recovery with ON‐resonant water suppression (IRON)
Korosoglou, G., Tang, L., Kedziorek, D., Cosby, K., Gilson, W. D., Vonken, E.-J. P. A., Schär, M., Sosnovik, D. E., Kraitchman, D. L., Weiss, R. G., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21337 · Cited by 22 · see citing works
Self-citationUnbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries
Kelly, K. A., Shaw, S. Y., Nahrendorf, M., Kristoff, K., Aikawa, E. R., Schreiber, S. L., Clemons, P. A., & Weissleder, R. (2009) · Integrative Biology · doi:10.1039/b821775k · Cited by 19 · see citing works
Self-citationIdentification of Molecular-Mimicry-Based Ligands for Cholera Diagnostics using Magnetic Relaxation
Kaittanis, C., Banerjee, T., Santra, S., et al. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100442q · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Imaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809 · see citing works
Magnetic nanoparticles for environmental and biomedical applications: a review
Mohammed, L., Gomaa, H. G., Ragab, D., & Zhu, J. (2017) · Particuology · doi:10.1016/j.partic.2016.06.001 · Cited by 682 · see citing works
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570 · see citing works
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Jin, R., Lin, B., Li, D., & Ai, H. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.08.002 · Cited by 305 · see citing works
Scioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281 · see citing works
Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics
Santhosh, P. B., & Ulrih, N. P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.04.032 · Cited by 236 · see citing works
Nanoparticles for Imaging: top or Flop?
Kiessling, F., Mertens, M. E., Grimm, J., & Lammers, T. (2014) · Radiology · doi:10.1148/radiol.14131520 · Cited by 228 · see citing works
Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics
Li, K., Nejadnik, H., & Daldrup-Link, H. E. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.04.008 · Cited by 139 · see citing works
Advances in Microbial Exopolysaccharides: Present and Future Applications
Nguyen, H.-T., Pham, T.-T., Nguyen, P.-T., Le-Buanec, H., Rabetafika, H. N., & Razafindralambo, H. L. (2024) · Biomolecules · doi:10.3390/biom14091162 · Cited by 101 · see citing works
Al Faraj, A., Sultana Shaik, A., Afzal, S., Al Sayed, B., & Halwani, R. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s59394 · Cited by 83 · see citing works
Prediction of anti-cancer nanotherapy efficacy by imaging
Miller, M. A., Arlauckas, S., & Weissleder, R. (2017) · Nanotheranostics · doi:10.7150/ntno.20564 · Cited by 74 · see citing works
Self-citationImproving nanotherapy delivery and action through image-guided systems pharmacology
Ng, T. S. C., Garlin, M. A., Weissleder, R., & Miller, M. A. (2020) · Theranostics · doi:10.7150/thno.37215 · Cited by 60 · see citing works
Self-citationRahmi, G., Pidial, L., Silva, A. K. A., Blondiaux, E., Meresse, B., Gazeau, F., Autret, G., Balvay, D., Cuenod, C. A., Perretta, S., et al. (2016) · Theranostics · doi:10.7150/thno.14064 · Cited by 26 · see citing works
- Authors
- Tassa, C., Shaw, S. Y., & Weissleder, R.
- Affiliations
- Harvard University (US)
- Corresponding author
- Weissleder, Ralph
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-06-10
- Volume
- 44
- Issue
- 10
- Pages
- 842-852
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- PMC
- PMC3182289
- OpenAlex
- W2001338329
- Cited by
- 653
- References
- 73
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 29 · 2023: 40 · 2022: 42 · 2021: 39 · 2020: 44 · 2019: 35 · 2018: 40 · 2017: 41 · 2016: 52 · 2015: 62 · 2014: 76 · 2013: 73 · 2012: 48
- FWCI
- 26.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Accounts of Chemical Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (2r01eb010011-05)
- National Heart, Lung, and Blood Institute (HHSN268201000044C)
- National Institute of Biomedical Imaging and Bioengineering (R01 EB-010 011, R01EB004626)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- superparamagnetic iron oxide nanoparticles, targeted molecular imaging, molecular diagnosis, theranostics, personalized medicine, surface plasmon resonance, multiplexed imaging, targeted photodynamic therapy, targeted drug delivery, magnetic resonance imaging, positron emission tomography, fluorescence imaging
- MeSH terms
- Animals, Dextrans, Ferric Compounds, Humans, Nanomedicine, Nanoparticles, Molecular Imaging, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
