Cited by 262Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersSchizophrenia research and treatment

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Comparative genomics of autism and schizophrenia

Open access

Crespi, Bernard, Stead, Philip, Elliot, Michael·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0906080106PMC PMC2868282

Open this paper in CoChat — free account

Abstract

We used data from studies of copy-number variants (CNVs), single-gene associations, growth-signaling pathways, and intermediate phenotypes associated with brain growth to evaluate four alternative hypotheses for the genomic and developmental relationships between autism and schizophrenia: ( i ) autism subsumed in schizophrenia, ( ii ) independence, ( iii ) diametric, and ( iv ) partial overlap. Data from CNVs provides statistical support for the hypothesis that autism and schizophrenia are associated with reciprocal variants, such that at four loci, deletions predispose to one disorder, whereas duplications predispose to the other. Data from single-gene studies are inconsistent with a hypothesis based on independence, in that autism and schizophrenia share associated genes more often than expected by chance. However, differentiation between the partial overlap and diametric hypotheses using these data is precluded by limited overlap in the specific genetic markers analyzed in both autism and schizophrenia. Evidence from the effects of risk variants on growth-signaling pathways shows that autism-spectrum conditions tend to be associated with up-regulation of pathways due to loss of function mutations in negative regulators, whereas schizophrenia is associated with reduced pathway activation. Finally, data from studies of head and brain size phenotypes indicate that autism is commonly associated with developmentally-enhanced brain growth, whereas schizophrenia is characterized, on average, by reduced brain growth. These convergent lines of evidence appear most compatible with the hypothesis that autism and schizophrenia represent diametric conditions with regard to their genomic underpinnings, neurodevelopmental bases, and phenotypic manifestations as reflecting under-development versus dysregulated over-development of the human social brain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0906080106

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Untitled work
(1943) · The Nervous child · Cited by 8,870
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
The weak coherence account: detail-focused cognitive style in autism spectrum disorders
Happé, F., & Frith, U. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0039-0 · Cited by 2,884
Strong association of de novo copy number mutations with autism
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Autistic disturbances of affective contact.
Kanner, L. (1968) · PubMed · Cited by 2,282
Structural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · cited 1×
“2 to 15q13 (and sometimes including these four genes) are awell-documented risk factor for autism, with seven such duplications reported in the autism studies considered here (16, 25, 26, 28).”
Background
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745

Flagged first, then by citations

Show all 106 references

Sorted by citations

Items 101–200 of 262

DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases
Quick, V. B. S., Davis, J. M., D, A. O. M., & Sikela, J. M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.192 · Cited by 41
Revisiting Bleuler: relationship between autism and schizophrenia
Crespi, B. J. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.196.6.495 · Cited by 41
Self-citation
Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder
Gadow, K. D., DeVincent, C. J., Siegal, V. I., Olvet, D. M., Kibria, S., Kirsch, S. F., & Hatchwell, E. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.019 · Cited by 43
Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk
Kulminski, A. M., Philipp, I., Shu, L., & Culminskaya, I. V. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.09.009 · Cited by 40
Annual Research Review: Impact of advances in genetics in understanding developmental psychopathology
Addington, A. M., & Rapoport, J. L. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02478.x · Cited by 41
Religious Studies as a Life Science
Bulbulia, J. A., Bulbulia, J. A., & Slingerland, E. (2012) · Numen · doi:10.1163/15685276-12341240 · Cited by 39
New mutations and intellectual function
Lupski, J. R. (2010) · Nature Genetics · doi:10.1038/ng1210-1036 · Cited by 37
Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis
de Jong, S., Newhouse, S., Patel, H., Lee, S., Dempster, D., Curtis, C. J. C., Paya-Cano, J. L., Murphy, D., Wilson, C., Horder, J., et al. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.115.175471 · Cited by 37
Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
Onaivi, E. S., Benno, R. H., Halpern, T., Mehanovic, M., Schanz, N., Sanders, C., Yan, X., Ishiguro, H., Liu, Q.-R., Llorente‐Berzal, A., et al. (2011) · Current Neuropharmacology · doi:10.2174/157015911795017047 · Cited by 37
Animal model integration to AutDB, a genetic database for autism
Kumar, A., Wadhawan, R., Swanwick, C. C., Kollu, R., Basu, S. N., & Banerjee‐Basu, S. (2011) · BMC Medical Genomics · doi:10.1186/1755-8794-4-15 · Cited by 35
Schizophrenia spectrum and attention-deficit/hyperactivity disorder symptoms in autism spectrum disorder and controls
Gadow, K. D. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.001 · Cited by 36
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay
Takenouchi, T., Hashida, N., Torii, C., Kosaki, R., Takahashi, T., & Kosaki, K. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36240 · Cited by 36
The Imprinted Brain: How Genes Set the Balance Between Autism and Psychosis
Badcock, C. R. (2013) · Epigenetics and human health · doi:10.1007/978-3-642-36827-1_5 · Cited by 36
The diagnostic boundary between autism spectrum disorder, intellectual developmental disorder and schizophrenia spectrum disorders
Bertelli, M. O., Merli, M. P., Bradley, E. A., Keller, R., Varrucciu, N., Furia, C. D., & Panocchia, N. (2015) · Advances in Mental Health and Intellectual Disabilities · doi:10.1108/amhid-05-2015-0024 · Cited by 36
Implications of holistic face processing in autism and schizophrenia
Watson, T. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00414 · Cited by 45
Distribution of Disease-Associated Copy Number Variants Across Distinct Disorders of Cognitive Development
Pescosolido, M. F., Uzun, E. D. G., Nagpal, S., & Morrow, E. M. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.01.003 · Cited by 35
Interaction of neurodevelopmental pathways and synaptic plasticity in mental retardation, autism spectrum disorder and schizophrenia: Implications for psychiatry
Waltereit, R., Banaschewski, T., Meyer‐Lindenberg, A., & Poustka, L. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.838641 · Cited by 34
Comparative Gene Expression Analysis of Two Mouse Models of Autism: Transcriptome Profiling of the BTBR and En2−/− Hippocampus
Provenzano, G., Corradi, Z., Monsorno, K., Fedrizzi, T., Ricceri, L., Scattoni, M. L., & Bozzi, Y. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00396 · Cited by 37
Differential sensory fMRI signatures in autism and schizophrenia: Analysis of amplitude and trial-to-trial variability
Haigh, S. M., Gupta, A., Barb, S. M., Glass, S. A. F., Minshew, N. J., Dinstein, I., Heeger, D. J., Eack, S. M., & Behrmann, M. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.03.036 · Cited by 40
Strong impact of natural-selection–free heterogeneity in genetics of age-related phenotypes
Kulminski, A. M., Huang, J. V., Loika, Y., Arbeev, K. G., Bagley, O., Yashkin, A. P., Duan, M., & Culminskaya, I. V. (2018) · Aging · doi:10.18632/aging.101407 · Cited by 31
Psychosocial functioning in the balance between autism and psychosis: evidence from three populations
Abu-Akel, A. M., Wood, S. J., Upthegrove, R., Chisholm, K., Lin, A. P., Hansen, P., Gillespie, S. M., Apperly, I. A., & Montag, C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01543-5 · Cited by 34
Comparison of Children with Autism Spectrum Disorder with and Without Schizophrenia Spectrum Traits: Gender, Season of Birth, and Mental Health Risk Factors
Gadow, K. D., & DeVincent, C. J. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1473-4 · Cited by 33
Differential profiles in auditory social cognition deficits between adults with autism and schizophrenia spectrum disorders: A preliminary analysis
Tobe, R. H., Corcoran, C. M., Breland, M. M., MacKay‐Brandt, A., Klim, C. C., Colcombe, S. J., LEVENTHAL, B. L., & Javitt, D. C. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.04.005 · Cited by 36
Autism Tendencies and Psychosis Proneness Interactively Modulate Saliency Cost
Abu-Akel, A. M., Apperly, I. A., Wood, S. J., Hansen, P., & Mevorach, C. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw066 · Cited by 33
The emergence of human‐evolutionary medical genomics
Crespi, B. J. (2010) · Evolutionary Applications · doi:10.1111/j.1752-4571.2010.00156.x · Cited by 32
Self-citation
Evolutionary conservation in genes underlying human psychiatric disorders
Ogawa, L. M., & Vallender, E. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00283 · Cited by 33
Williams syndrome deletions and duplications: Genetic windows to understanding anxiety, sociality, autism, and schizophrenia
Crespi, B. J., & Procyshyn, T. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.004 · Cited by 32
Self-citation
Autism, Psychosis, or Both? Unraveling Complex Patient Presentations
Chandrasekhar, T., Copeland, J. N., Spanos, M., & Sikich, L. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.08.003 · Cited by 29
Genetic and regulatory architecture of Alzheimer's disease in the APOE region
Kulminski, A. M., Shu, L., Loika, Y., He, L., Nazarian, A., Arbeev, K. G., Ukraintseva, S. V., Yashin, A. I., & Culminskaya, I. V. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12008 · Cited by 29
Characterization of the Deleted in Autism 1 Protein Family: Implications for Studying Cognitive Disorders
Aziz, A., Harrop, S. P., & Bishop, N. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014547 · Cited by 31
A maternal influence on Reading the Mind in the Eyes mediated by executive function: differential parental influences on full and half-siblings
Ragsdale, G., & Foley, R. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023236 · Cited by 29
Sulindac attenuates valproic acid-induced oxidative stress levels in primary cultured cortical neurons and ameliorates repetitive/stereotypic-like movement disorders in Wistar rats prenatally exposed to valproic acid
Zhang, Y., Cailing, Y., YUAN, G.-Y., WANG, Z., Cui, W., & Li, R. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1996 · Cited by 31
Uncovering convergence and divergence between autism and schizophrenia using genomic tools and patients’ neurons
Romanovsky, E., Choudhary, A., Peles, D., Abu-Akel, A. M., & Stern, S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02740-0 · Cited by 27
APOE region molecular signatures of Alzheimer's disease across races/ethnicities
Kulminski, A. M., Shu, L., Loika, Y., Nazarian, A., Arbeev, K. G., Ukraintseva, S. V., Yashin, A. I., & Culminskaya, I. V. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.11.007 · Cited by 28
MYT1L: A systematic review of genetic variation encompassing schizophrenia and autism
Mansfield, P., Constantino, J. N., & Baldridge, D. (2020) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32781 · Cited by 27
Qualitative Differences in Attribution of Mental States to Other People in Autism and Schizophrenia: What are the Tools for Differential Diagnosis?
Mazza, M., Pino, M. C., Keller, R., Vagnetti, R., Attanasio, M., Filocamo, A., Donne, I. L., Masedu, F., & Valenti, M. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05035-3 · Cited by 29
Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia
Mitelman, S. A., Bralet, M., Haznedar, M. M., Hollander, E., Shihabuddin, L., Hazlett, E. A., & Buchsbaum, M. S. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9648-9 · Cited by 29
A predictive coding account of psychotic symptoms in autism spectrum disorder
van Schalkwyk, G. I., Volkmar, F. R., & Corlett, P. R. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3065-9 · Cited by 25
Association of schizophrenia spectrum and autism spectrum disorder (ASD) symptoms in children with ASD and clinic controls
Gadow, K. D. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.01.011 · Cited by 30
The Strategies of the Genes: Genomic Conflicts, Attachment Theory, and Development of the Social Brain
Crespi, B. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_8 · Cited by 25
Self-citation
Association of Genetic Variants on 15q12 With Cortical Thickness and Cognition in Schizophrenia
Bakken, T. E. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.81 · Cited by 25
Cross-Disorder Psychiatric Genomics
Docherty, A. R., Moscati, A., & Fanous, A. H. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0084-3 · Cited by 26
Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences
Byars, S., & Boomsma, J. J. (2016) · Evolution Medicine and Public Health · doi:10.1093/emph/eow023 · Cited by 25
Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality
Kulminski, A. M., He, L., Culminskaya, I. V., Loika, Y., Kernogitski, Y., Arbeev, K. G., Loiko, E., Arbeeva, L. S., Bagley, O., Duan, M., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006314 · Cited by 25
Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates
Boddy, A. M., Harrison, P. W., Montgomery, S. H., Caravas, J., Raghanti, M. A., Phillips, K. A., Mundy, N. I., & Wildman, D. E. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx028 · Cited by 24
The association of excitation and inhibition signaling with the relative symptom expression of autism and psychosis-proneness: Implications for psychopharmacology
Ford, T. C., Abu-Akel, A. M., & Crewther, D. P. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.07.024 · Cited by 25
A VNTR Regulates miR-137 Expression Through Novel Alternative Splicing and Contributes to Risk for Schizophrenia
Pacheco, A., Berger, R., Freedman, R., & Law, A. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-48141-0 · Cited by 24
Diametric effects of autism tendencies and psychosis proneness on attention control irrespective of task demands
Abu-Akel, A. M., Apperly, I. A., Spaniol, M. M., Geng, J. J., & Mevorach, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-26821-7 · Cited by 23
Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment
Crespi, B. J. (2019) · Evolution Medicine and Public Health · doi:10.1093/emph/eoz022 · Cited by 24
Self-citation
Rare Genomic Deletions and Duplications and their Role in Neurodevelopmental Disorders
Glessner, J., Connolly, J. J., & Hakonarson, H. H. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_179 · Cited by 24
No evidence of associations between genetic liability for schizophrenia and development of cannabis use disorder
Hjorthøj, C. R., Uddin, M. J., Wimberley, T., Dalsgaard, S., HOUGAARD, D. M., Børglum, A. D., Werge, T. M., & Nordentoft, M. (2019) · Psychological Medicine · doi:10.1017/s0033291719003362 · Cited by 21
The Evolutionary Biology of Human Neurodevelopment
Crespi, B. J., & Leach, E. (2015) · Wiley eBooks · doi:10.1002/9781118524756.ch9 · Cited by 21
Self-citation
mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
Nguyen, T.-H., Dobbyn, A. L., Brown, R. C., Riley, B. P., Buxbaum, J. D., Pinto, D., Purcell, S., Sullivan, P. F., He, X., & Stahl, E. A. (2020) · Nature Communications · doi:10.1038/s41467-020-16487-z · Cited by 20
Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes
Leone, R., Zuglian, C., Brambilla, R., & Morella, I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407865 · Cited by 22
Testing the ‘Extreme Female Brain’ Theory of Psychosis in Adults with Autism Spectrum Disorder with or without Co-Morbid Psychosis
Larson, F. V., Lai, M., Wagner, A. P., Baron‐Cohen, S., & Holland, A. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128102 · Cited by 20
Distinctive Rorschach profiles of young adults with schizophrenia and autism spectrum disorder
Kimoto, S., Kishimoto, N., Yamamuro, K., Iida, J., Ota, T., Tanaka, S., Kyo, M., & Kishimoto, T. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s116223 · Cited by 17
Abnormally Large Baseline P300 Amplitude Is Associated With Conversion to Psychosis in Clinical High Risk Individuals With a History of Autism: A Pilot Study
Foss‐Feig, J. H., Guillory, S. B., Roach, B. J., Velthorst, E., Hamilton, H., Bachman, P., Belger, A., Carrión, R. E., Duncan, E., Johannesen, J., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.591127 · Cited by 17
The Evolutionary Etiologies of Autism Spectrum and Psychotic Affective Spectrum Disorders
Crespi, B. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-29716-3_20 · Cited by 17
Self-citation
Psychiatric Disorders and Cannabinoid Receptors
Joshi, N., & Onaivi, E. S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-57369-0_9 · Cited by 19
Evolutionary Trends of Polygenic Scores in European Populations From the Paleolithic to Modern Times
Piffer, D., & Kirkegaard, E. O. W. (2024) · Twin Research and Human Genetics · doi:10.1017/thg.2024.8 · Cited by 15
Diametric gene-dosage effects as windows into neurogenetic architecture
Crespi, B. J. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.08.005 · Cited by 14
Self-citation
2018 Victor A. McKusick Leadership Award: Molecular Mechanisms for Genomic and Chromosomal Rearrangements
Lupski, J. R. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.12.018 · Cited by 15
CYFIP1 Dosages Exhibit Divergent Behavioral Impact via Diametric Regulation of NMDA Receptor Complex Translation in Mouse Models of Psychiatric Disorders
Kim, N.-S., Ringeling, F. R., Zhou, Y., Nguyen, H. N., Temme, S. J., Lin, Y.-T., Eacker, S., Dawson, V. L., Dawson, T. M., Xiao, B., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.023 · Cited by 15
Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart‐related traits
Kulminski, A. M., Kernogitski, Y., Culminskaya, I. V., Loika, Y., Arbeev, K. G., Bagley, O., Duan, M., Arbeeva, L. S., Ukraintseva, S. V., Wu, D., et al. (2016) · Aging Cell · doi:10.1111/acel.12526 · Cited by 14
Overlap between autism and schizophrenia: history and current status
Fitzgerald, M. (2013) · Advances in Mental Health and Intellectual Disabilities · doi:10.1108/amhid-09-2013-0058 · Cited by 14
One Hundred Years of Insanity: Genomic, Psychological, and Evolutionary Models of Autism in Relation to Schizophrenia
Crespi, B. J. (2011) · Springer eBooks · doi:10.1007/978-94-007-0837-2_7 · Cited by 13
Self-citation
A scoring strategy combining statistics and functional genomics supports a possible role for common polygenic variation in autism
Carayol, J., Schellenberg, G. D., Dombroski, B. A., Amiet, C., Génin, B., Fontaine, K., Rousseau, F., Vazart, C., Cohen, D., Frazier, T. W., et al. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00033 · Cited by 13
How selves differ within and across cognitive domains: self-prioritisation, self-concept, and psychiatric traits
Perrykkad, K., & Hohwy, J. (2022) · BMC Psychology · doi:10.1186/s40359-022-00870-0 · Cited by 14
Cognitive biases as an adaptive strategy in autism and schizophrenia spectrum: the compensation perspective on neurodiversity
Rządeczka, M., Wodziński, M. C., & Moskalewicz, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1291854 · Cited by 17
Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms
Kulminski, A. M., Loika, Y., Huang, J. V., Arbeev, K. G., Bagley, O., Ukraintseva, S. V., Yashin, A. I., & Culminskaya, I. V. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00433 · Cited by 12
Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies
Jin, F., & Wang, Z. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1514678 · Cited by 12
Seeing minds – a signal detection study of agency attribution along the autism-psychosis continuum
Lisøy, R. S., Biegler, R., Haghish, E. F., Veckenstedt, R., Moritz, S., & Pfuhl, G. (2022) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2022.2075721 · Cited by 9
Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity
Hsu, K.-C., & Wang, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179575 · Cited by 11
Lifetime Autism Spectrum Features in a Patient with a Psychotic Mixed Episode Who Attempted Suicide
Simoncini, M., Miniati, M., Vanelli, F., Callari, A., Vannucchi, G., Mauri, M., & Dell’Osso, L. (2014) · Case Reports in Psychiatry · doi:10.1155/2014/459524 · Cited by 10
Longitudinal report of child with de novo 16p11.2 triplication
Wallace, A. S., Hudac, C. M., Steinman, K. J., Peterson, J. L., DesChamps, T. D., Duyzend, M. H., Nuttle, X., Eichler, E. E., & Bernier, R. A. (2018) · Clinical Case Reports · doi:10.1002/ccr3.1236 · Cited by 9
Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population
Lo, T., Kushima, I., Aleksić, B., Kato, H., Nawa, Y., Hayashi, Y., Otgonbayar, G., Kimura, H., Arioka, Y., Mori, D., et al. (2022) · International Review of Psychiatry · doi:10.1080/09540261.2022.2072193 · Cited by 8
Brain Copy Number Variants and Neuropsychiatric Traits
Lupski, J. R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.007 · Cited by 9
Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia
Haigh, S. M., Key, L. V., Brosseau, P., Eack, S. M., Leitman, D. I., Salisbury, D. F., & Behrmann, M. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05771-0 · Cited by 9
Facial Dimorphism in Autistic Quotient Scores
Scott, N. J., Jones, A. L., Kramer, R. S. S., & Ward, R. D. (2014) · Clinical Psychological Science · doi:10.1177/2167702614534238 · Cited by 9
eQTLs Weighted Genetic Correlation Analysis Detected Brain Region Differences in Genetic Correlations for Complex Psychiatric Disorders
Wen, Y. F., Zhang, F., Ma, X., Fan, Q., Wang, W., Xu, J., Zhu, F., Hao, J., He, A., Liu, L., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby080 · Cited by 9
Evolutionary Psychology and Mental Health
Nesse, R. M. (2015) · Wiley eBooks · doi:10.1002/9781119125563.evpsych243 · Cited by 10
Shared and Distinct Genetic Influences Between Cognitive Domains and Psychiatric Disorder Risk Based on Genome-Wide Data
Carey, C. E., Strong, R. W., Huang, Y., Aslibekyan, S. W., Gentleman, R. C., Smoller, J. W., Wilmer, J. B., Robinson, E., & Germine, L. T. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.130 · Cited by 8
Genetic Approaches to Understanding Psychiatric Disease
Michaelson, J. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0551-x · Cited by 11
Dissecting genetic cross-talk between ADHD and other neurodevelopmental disorders: Evidence from behavioural, pharmacological and brain imaging investigations
Sengupta, S. M., Fotopoulos, N. H., Devenyi, G. A., Fortier, M., Ter-Stepanian, M., Sagliker, S., Karama, S., Chakravarty, M. M., Labbe, A., Grizenko, N., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.080 · Cited by 8
Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia
Shi, L., Zhou, H., Shen, Y., Wang, Y., Fang, Y., He, Y., Ou, J., Luo, X., Cheung, E. F. C., & Chan, R. C. K. (2019) · Autism Research · doi:10.1002/aur.2231 · Cited by 11
Drug development in pediatric psychiatry: current status, future trends
March, J. S., & Fegert, J. M. (2012) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-6-7 · Cited by 7
The genome, microbiome and evolutionary medicine
Brunham, R. C. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.170846 · Cited by 7
Neurodevelopmental Plasticity in Pre- and Postnatal Environmental Interactions: Implications for Psychiatric Disorders from an Evolutionary Perspective
Lee, Y., Yamaguchi, Y., & Goto, Y. (2015) · Neural Plasticity · doi:10.1155/2015/291476 · Cited by 7
Impulsiveness and Inhibitory Mechanisms
Bari, A., Kellermann, T. S., & Studer, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800935-2.00006-3 · Cited by 11
The NBPF Gene Family
Andries, V., Vandepoele, K., & van, F. (2012) · InTech eBooks · doi:10.5772/28470 · Cited by 6
Prefrontal Cortical-Cerebellar Interaction Deficits in Autism Spectrum Disorders
Heck, D. H., & Howell, J. W. (2013) · Autism - Open Access · doi:10.4172/2165-7890.s4-001 · Cited by 6
The hallmarks of autism
Crespi, B. J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.937163 · Cited by 6
Self-citation
Autism and Schizophrenia: Genetic and Phenotypic Relationships
Vorstman, J. A. S., & Burbach, J. P. H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4788-7_96 · Cited by 6
Reconciling genetic evolution and the associative learning account of mirror neurons through data-acquisition mechanisms
Lotem, A., & Kolodny, O. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x13002392 · Cited by 6
The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism
Shilbayeh, S. A. R., Adeen, I. S., Alhazmi, A. S., Aljurayb, H., Altokhais, R. S., Alhowaish, N., Aldilaijan, K. E., Kamal, M., & Alnakhli, A. M. (2024) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-024-03658-w · Cited by 5
A Comparison of Autistic Like Traits in the Relatives of Patients with Autism and Schizophrenia Spectrum Disorder.
Khanjani, Z., Azmoodeh, S., Mahmoud-Aliloo, M., & Noorazar, G. (2018) · Europe PMC (PubMed Central) · Cited by 5
Assessing the diametrical model of schizotypal and autistic traits in emotion recognition and social functioning in a community sample
Fan, L., Springfield, C. R., Klein, H., Ackerman, R. A., Sasson, N. J., & Pinkham, A. E. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.09.038 · Cited by 6
DNA methylation profiles of transgenerational rat hyperactivity primed by silver nanoparticles: Comparison with valproate model rats of autism
Ishido, M., Higashi, K., Mori, H., Ueno, M., & Kurokawa, K. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115293 · Cited by 5
Autism, an overwhelming condition: history, etiopathogenesis, types, diagnosis, therapy and prognosis.
Amihăesei, I. C., & Stefanachi, E. (2013) · The Medical-Surgical Journal · Cited by 5
Reconsideration of animal models of schizophrenia and other psychiatric disorders with evolutionary perspective
Lee, Y.-A., & Goto, Y. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.10.017 · Cited by 5

Authors: Crespi, B., Stead, P., & Elliot, M.
Affiliations: Simon Fraser University (CA)
ORCID: Crespi, Bernard
Elliot, Michael
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-01-26
Volume: 107
Issue: suppl_1
Pages: 1736-1741
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0906080106
PMC: PMC2868282
OpenAlex: W2021377987
Cited by: 262
References: 106
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 8 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 23 · 2015: 19 · 2014: 18 · 2013: 24 · 2012: 26
FWCI: 11.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: autism spectrum disorder, schizophrenia, copy number variation, brain growth, head size, brain size, shared genetic risk loci, brain development, social brain
MeSH terms: Autistic Disorder, Humans, Schizophrenia, Gene Dosage, Genomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Comparative genomics of autism and schizophrenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks