Control of bud activation by an auxin transport switch
Open accessAbstract
In many plant species only a small proportion of buds yield branches. Both the timing and extent of bud activation are tightly regulated to produce specific branching architectures. For example, the primary shoot apex can inhibit the activation of lateral buds. This process is termed apical dominance and is dependent on the plant hormone auxin moving down the main stem in the polar auxin transport stream. We use a computational model and mathematical analysis to show that apical dominance can be explained in terms of an auxin transport switch established by the temporal precedence between competing auxin sources. Our model suggests a mechanistic basis for the indirect action of auxin in bud inhibition and captures the effects of diverse genetic and physiological manipulations. In particular, the model explains the surprising observation that highly branched Arabidopsis phenotypes can exhibit either high or low auxin transport.
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SL decreases the amount of PIN auxin efflux carrier at the membrane and lowers auxin transport capacity in the stem.
“In contrast to cytokinin, SL appears to decrease the amount of the PIN auxin efflux carrier at the membrane and, thus, lower auxin transport capacity in the stem.”
From Shaping plant architecture (2015) · cites this paper as Prusinkiewicz et al., 2009
According to the auxin transport canalization model, SLs aggravate establishment of auxin export from axillary buds, leading to increased apical dominance.
“According to the auxin transport canalization model, SLs will, therefore, aggravate the establishment of auxin export from axillary buds, leading to increased apical dominance (Prusinkiewicz et al., 2009).”
From Shaping plant architecture (2015) · cites this paper as Prusinkiewicz et al., 2009
Stems of Arabidopsis SL-pathway mutants show increased AtPIN1 levels and increased auxin transport.
“This was observed in stems of Arabidopsis SL-pathway mutants, which showed increased AtPIN1 levels as well as an increased auxin transport (Bennett et al., 2006; Prusinkiewicz et al., 2009).”
From Shaping plant architecture (2015) · cites this paper as Prusinkiewicz et al., 2009
Cites
Sites and homeostatic control of auxin biosynthesis in <i>Arabidopsis</i> during vegetative growth
Ljung, K., Bhalerao, R. P., & Sandberg, G. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01173.x · Cited by 653 · see citing works
Self-citationSorefan, K., Booker, J., Haurogné, K., Goussot, M., Bainbridge, K., Foo, E., Chatfield, S., Ward, S., Beveridge, C., Rameau, C., et al. (2003) · Genes & Development · doi:10.1101/gad.256603 · Cited by 604 · see citing works
Self-citationCanalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of PIN polarity
Sauer, M., Balla, J., Luschnig, C., Wiśniewska, J., Reinöhl, V., Friml, J., & Benková, E. (2006) · Genes & Development · doi:10.1101/gad.390806 · Cited by 453 · see citing works
Strigolactone Acts Downstream of Auxin to Regulate Bud Outgrowth in Pea and Arabidopsis
Brewer, P. B., Dun, E. A., Ferguson, B. J., Rameau, C., & Beveridge, C. A. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.134783 · Cited by 418 · cited 1× · see citing works
“Furthermore, the behavior of the model is consistent with recent observations that transport of auxin in the stem is not saturated (17), and thus the interaction between auxin sources is not mediated by limiting transport capacity of the stem.”
Cline, M. G. (1991) · The Botanical Review · doi:10.1007/bf02858771 · Cited by 380 · see citing works
Morris, D. A. (1977) · Planta · doi:10.1007/bf00387930 · Cited by 165 · see citing works
<i>AXR1</i> Acts after Lateral Bud Formation to Inhibit Lateral Bud Growth in Arabidopsis
Stirnberg, P., Chatfield, S. P., & Leyser, H. M. O. (1999) · Plant Physiology · doi:10.1104/pp.121.3.839 · Cited by 152 · see citing works
Li, C., & Bangerth, F. (1999) · Physiologia Plantarum · doi:10.1034/j.1399-3054.1999.106409.x · Cited by 130 · see citing works
Grbić, V., & Bleecker, A. B. (1996) · Development · doi:10.1242/dev.122.8.2395 · Cited by 66 · see citing works
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Sugar demand, not auxin, is the initial regulator of apical dominance
Mason, M. G., Ross, J. J., Babst, B. A., Wienclaw, B. N., & Beveridge, C. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322045111 · Cited by 565 · see citing works
Strigolactones affect lateral root formation and root-hair elongation in Arabidopsis
Kapulnik, Y., Delaux, P.-M., Resnick, N., Mayzlish-Gati, E., Wininger, S., Bhattacharya, C., Séjalon-Delmas, N., Combier, J.-P., Bécard, G., Belausov, E., et al. (2011) · Planta · doi:10.1007/s00425-010-1310-y · Cited by 502 · see citing works
The Pea TCP Transcription Factor PsBRC1 Acts Downstream of Strigolactones to Control Shoot Branching
Braun, N., de Saint Germain, A., Pillot, J.-P., Boutet-Mercey, S., Dalmais, M., Antoniadi, I., Li, X., Maia-Grondard, A., Le Signor, C., Bouteiller, N., et al. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.182725 · Cited by 486 · see citing works
Shinohara, N., Taylor, C., & Leyser, O. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001474 · Cited by 438 · see citing works
Self-citationStrigolactones enhance competition between shoot branches by dampening auxin transport
Crawford, S., Shinohara, N., Sieberer, T., Williamson, L., George, G., Hepworth, J., Müller, D., Domagalska, M. A., & Leyser, O. (2010) · Development · doi:10.1242/dev.051987 · Cited by 384 · see citing works
Self-citationMultiple pathways regulate shoot branching
Rameau, C., Bertheloot, J., Leduc, N., Andrieu, B., Foucher, F., & Sakr, S. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00741 · Cited by 357 · see citing works
<i>BRANCHED1</i> Promotes Axillary Bud Dormancy in Response to Shade in <i>Arabidopsis</i>
González-Grandío, E., Poza-Carrión, C., Sorzano, C. O. S., & Cubas, P. (2013) · The Plant Cell · doi:10.1105/tpc.112.108480 · Cited by 272 · see citing works
Strigolactones and the control of plant development: lessons from shoot branching
Waldie, T., McCulloch, H., & Leyser, O. (2014) · The Plant Journal · doi:10.1111/tpj.12488 · Cited by 242 · see citing works
Self-citationTeichmann, T., & Muhr, M. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00233 · Cited by 228 · see citing works
“This was observed in stems of Arabidopsis SL-pathway mutants, which showed increased AtPIN1 levels as well as an increased auxin transport (Bennett et al., 2006; Prusinkiewicz et al., 2009).”
BackgroundMethodInfluentialPea has its tendrils in branching discoveries spanning a century from auxin to strigolactones
Beveridge, C. A., Dun, E. A., & Rameau, C. (2009) · Plant Physiology · doi:10.1104/pp.109.143909 · Cited by 79 · see citing works
Dun, E. A., Hanan, J., & Beveridge, C. A. (2009) · The Plant Cell · doi:10.1105/tpc.109.069013 · Cited by 71 · see citing works
Using Arabidopsis to Study Shoot Branching in Biomass Willow
Ward, S. P., Salmon, J., Hanley, S. J., Karp, A., & Leyser, O. (2013) · Plant Physiology · doi:10.1104/pp.113.218461 · Cited by 25 · see citing works
Self-citation
- Authors
- Prusinkiewicz, P., Crawford, S., Smith, R. S., Ljung, K., Bennett, T., Ongaro, V., & Leyser, O.
- Affiliations
- Department of Computer Science, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4;
- University of York (GB)
- University of Calgary (CA)
- Swedish University of Agricultural Sciences (SE)
- Department of Biology, University of York, York YO10 5YW, United Kingdom; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-10-13
- Volume
- 106
- Issue
- 41
- Pages
- 17431-17436
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2751654
- OpenAlex
- W2164734518
- Cited by
- 375
- References
- 9
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 16 · 2023: 16 · 2022: 25 · 2021: 28 · 2020: 30 · 2019: 27 · 2018: 21 · 2017: 17 · 2016: 14 · 2015: 22 · 2014: 23 · 2013: 23 · 2012: 24
- FWCI
- 28.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Funders
- Stiftelsen för Strategisk Forskning
- Vetenskapsrådet
- Directorate for Biological Sciences
- Natural Sciences and Engineering Research Council of Canada
- Biotechnology and Biological Sciences Research Council (BB/C518057/1)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Greenhouse Technology and Climate Control
- Keywords
- apical dominance, auxin transport, branching pattern, polar auxin transport, shoot apex, axillary buds, computational model, Arabidopsis thaliana
- MeSH terms
- Biological Transport, Computer Simulation, Homeostasis, Indoleacetic Acids, Kinetics, Models, Biological, Plant Roots, Meristem, Plant Shoots, Plant Physiological Phenomena, Flowers
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