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25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
Open accessAbstract
25-Hydroxycholesterol is produced in mammalian tissues. The function of this oxysterol is unknown. Here we describe a central role for 25-hydroxycholesterol in regulating the immune system. In initial experiments, we found that stimulation of macrophage Toll-like receptors (TLR) induced expression of cholesterol 25-hydroxylase and the synthesis of 25-hydroxycholesterol. Treatment of naïve B cells with nanomolar concentrations of 25-hydroxycholesterol suppressed IL-2-mediated stimulation of B cell proliferation, repressed activation-induced cytidine deaminase (AID) expression, and blocked class switch recombination, leading to markedly decreased IgA production. Consistent with these findings, deletion of the mouse cholesterol 25-hydroxylase gene caused an increase in serum IgA. Conversely, inactivation of the CYP7B1 oxysterol 7α-hydroxylase, which degrades 25-hydroxycholesterol, decreased serum IgA. The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system.
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“Mice lacking Ch25h appear to have a normal phenotype, show no changes in serum cytokine levels (Bauman et al., 2009), and have normal cholesterol metabolism (Reboldi et al., 2014).”
From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Bauman et al., 2009
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“We and others have previously shown that Ch25h is responsible for the production and secretion of 25-HC by microglia (Bauman et al., 2009; Wong et al., 2020)”
From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Bauman et al., 2009
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“Ch25h, the enzyme that hydroxylates cholesterol to 25-hydroxycholesterol (25HC) (9) is markedly upregulated by toll-like receptor activation of macrophages (10,11).”
From Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol (2023) · cites this paper as [10]
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“Mice lacking Ch25h appear to have a normal phenotype, show no changes in serum cytokine levels (Bauman et al., 2009), and have normal cholesterol metabolism (Reboldi et al., 2014).”
From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Bauman et al., 2009
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Revy, P., Muto, T., Lévy, Y., Geissmann, F., Plebani, A., Sanal, Ö., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,645
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,591
Inferences, questions and possibilities in Toll-like receptor signalling
Beutler, B. (2004) · Nature · doi:10.1038/nature02761 · Cited by 1,476
Mechanism and Regulation of Class Switch Recombination
Stavnezer, J., Guikema, J. E. J., & Schrader, C. E. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090248 · Cited by 1,195
The immune geography of IgA induction and function
Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047
The regulation of IgA class switching
Cerutti, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2322 · Cited by 777
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Items 201–300 of 330
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Saulle, I., Ibba, S. V., Vittori, C., Fenizia, C., Mercurio, V., Vichi, F., Caputo, S. L., Trabattoni, D., Clerici, M., & Biasin, M. (2020) · AIDS · doi:10.1097/qad.0000000000002591 · Cited by 18
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Su, Y., Liu, S., Long, C., Zhou, Z., Zhou, Y., & Tang, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113463 · Cited by 16
Oncogenic roles of the cholesterol metabolite 25‑hydroxycholesterol in bladder cancer
Wang, C., He, H., & Fang, W. (2020) · Oncology Letters · doi:10.3892/ol.2020.11475 · Cited by 17
Tang, J., Shi, Y., Zhan, L., & Qin, C. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104234 · Cited by 17
Velasco‐Estevez, M., Koch, N., Klejbor, I., Laurent, S., Dev, K. K., Szutowicz, A., Sailer, A. W., & Rutkowska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094342 · Cited by 15
Sterols and immune mechanisms in asthma
Britt, R. D., Porter, N. A., Grayson, M. H., Gowdy, K. M., Ballinger, M. N., Wada, K. J., Kim, H., & Guerau‐de‐Arellano, M. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.09.025 · Cited by 17
Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity
Zhong, G., He, C., Wang, S., Lin, C., & Li, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1241262 · Cited by 17
Zhou, S., Wen, X., Zhang, D., Li, D., Ding, C., Song, J., Huang, W.-F., Jin, Z., Zhou, Z., Xia, X., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109204 · Cited by 16
Tuong, Z. K., Lau, P., Yeo, J. C., Pearen, M. A., Wall, A. A., Stanley, A. C., Stow, J. L., & Muscat, G. E. O. (2013) · Endocrinology · doi:10.1210/en.2012-1889 · Cited by 16
Dong, H., Zhou, L., Ge, X., Guo, X., Han, J., & Yang, H. (2017) · Antiviral Therapy · doi:10.3851/imp3232 · Cited by 16
Involvement of lipid droplets in hepatic responses to lipopolysaccharide treatment in mice
Arisqueta, L., Núñez-García, M., Ogando, J., García‐Arcos, I., Ochoa, B., Aspichueta, P., Fresnedo, O., & Rueda, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.015 · Cited by 16
Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects
Ghosh, S., Ghzaiel, I., Véjux, A., Meaney, S., Nag, S., Lizard, G., Tripathi, G., Naez, F., & Paul, S. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_9 · Cited by 16
Implication of Oxysterols and Phytosterols in Aging and Human Diseases
Vigne, S., & Pot, C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_12 · Cited by 16
Harnessing m1A modification: a new frontier in cancer immunotherapy
Wang, X., Ma, X., Chen, S., Fan, M., Jin, C., Chen, Y., Wang, S., Wang, Z., Meng, F., Zhang, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1517604 · Cited by 19
Vihervaara, T., Käkelä, R., Liebisch, G., Tarassov, K., Schmitz, G., & Olkkonen, V. M. (2012) · Biochimie · doi:10.1016/j.biochi.2012.05.004 · Cited by 17
Trasino, S. E., Dawson, H. D., Urban, J. F., Wang, T. T. Y., & Solano-Aguilar, G. I. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.06.001 · Cited by 15
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Singaravelu, R., Srinivasan, P., & Pezacki, J. P. (2015) · Canadian Journal of Microbiology · doi:10.1139/cjm-2015-0292 · Cited by 14
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Ejam, S. S., Saleh, R. O., Opulencia, M. J. C., Najm, M. A. A., Makhmudova, A., Jalil, A. T., Abdelbasset, W. K., Al-Gazally, M. E., Hammid, A. T., Mustafa, Y. F., et al. (2022) · Future Oncology · doi:10.2217/fon-2022-0819 · Cited by 13
Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3
GC, J. B., Chen, J., Pokharel, S. M., Mohanty, I. P., Mariasoosai, C., Obi, P., Panipinto, P. M., Bandyopadhyay, S., Bose, S., & Natesan, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-36040-4 · Cited by 13
Gomes, B., Sanna, G., Madeddu, S., Hollmann, A., & Santos, N. C. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00321 · Cited by 13
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Wang, Y., Zhang, J., Chen, J., Wang, D., Yu, Y., Qiu, P., Wang, Q., Zhao, W., Zhao, L., & Lei, T. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022030 · Cited by 13
Izumi, Y., O’Dell, K. A., Cashikar, A. G., Paul, S. M., Covey, D. F., Mennerick, S. J., & Zorumski, C. F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304481 · Cited by 12
Dios, S., Balseiro, P., Costa, M. M., Romero, A., Boltaña, S., Roher, N., MacKenzie, S. A., Figueras, A. J., & Novoa, B. (2014) · Zebrafish · doi:10.1089/zeb.2014.0995 · Cited by 12
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Self-citationIzumi, Y., O’Dell, K. A., Mennerick, S. J., & Zorumski, C. F. (2025) · Scientific Reports · doi:10.1038/s41598-025-90149-2 · Cited by 10
Cho, S. J., Pronko, A., Yang, J., Pagan, K., & Stout-Delgado, H. W. (2023) · Cells · doi:10.3390/cells12040570 · Cited by 10
Gomes, B., Santos, N. C., & Porotto, M. (2017) · Molecules · doi:10.3390/molecules22111869 · Cited by 10
Dang, E. V., Madhani, H. D., & Vance, R. E. (2020) · Nature Immunology · doi:10.1038/s41590-020-0712-7 · Cited by 10
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Li, A., Guo, A., Chen, C., Ji, H., Jiang, N., Wang, Y., Zhou, Y., Zhu, Z., Hu, Y., & Wang, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.357905 · Cited by 9
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Jurewicz, A., Domowicz, M., Gałązka, G., Raine, C. S., & Selmaj, K. W. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24062 · Cited by 9
Myhill, L. J., Jensen, P., Zakeri, A., Nielsen, L. F., Jakobsen, S. R., Mejer, H., Thamsborg, S. M., Nejsum, P. L., & Williams, A. R. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.03.006 · Cited by 10
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Buñay, J., Ayadi, S., Gressein, C., de Médina, P., Silvente‐Poirot, S., & Poirot, M. (2026) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2026.03.001 · Cited by 8
Mai, C.-T., Zheng, D.-C., Li, X., Zhou, H., & Xie, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105747 · Cited by 9
Gawrysiak‐Witulska, M., Siger, A., Grygier, A., Rusinek, R., & Gancarz, M. (2022) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.202200035 · Cited by 8
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Wang, Y., Zuo, W., Zhang, Y., Bo, Z., Zhang, C., Zhang, X., & Wu, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1178005 · Cited by 7
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Takahashi, H., & Hoshino, T. (2020) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2020.104872 · Cited by 6
Ricci, R., Foo, C. X., Ronacher, K., & Cullen, C. L. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1709065 · Cited by 5
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Brown, A. J. (2012) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201100295 · Cited by 4
Lim, H., Oh, J., Kang, K., Seo, J., Kim, D. K., Yu, S., Kim, H., Park, J., & Kim, J. (2022) · International Endodontic Journal · doi:10.1111/iej.13878 · Cited by 4
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Azevedo‐Pereira, J. M., Canhão, P., Calado, M. S., Santos‐Costa, Q., & Barroca, P. (2015) · InTech eBooks · doi:10.5772/60795 · Cited by 4
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Lu, H., & Talbot, S. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/650465 · Cited by 3
Castellaneta, A., Losito, I., Crisau, C., Zöldhegyi, A., Hrušovská, Z., Rieger, H.-J., Molnár, I., & Cataldi, T. R. I. (2026) · Journal of Chromatography A · doi:10.1016/j.chroma.2026.466735 · Cited by 2
Wei, J., Yu, B., Wang, N., Huang, X., Su, S., Chen, Z., Hu, M., Wen, X., Liang, J., Shao, L., et al. (2026) · Discover Oncology · doi:10.1007/s12672-026-05474-3 · Cited by 2
Zheng, Y., Dobson, H. E., Pierre, M. J., LeBlanc, L. B., Onyishi, C. U., Golec, D. P., Carrillo, N., Deewan, A., Rivera, C. A., Ansaldo, E., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.aee0990 · Cited by 3
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Wang, Y., Yutuc, E., & Griffiths, W. J. (2020) · doi:10.22541/au.158713501.10820437 · Cited by 2
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Leber, A. J., Hontecillas, R., Tubau‐Juni, N., & Bassaganya-Riera, J. (2026) · International Journal of Radiation Biology · doi:10.1080/09553002.2026.2679142 · Cited by 1
Kapliukhina, E. A., Fedorov, N. S., Tsentsevitsky, A. N., Salnikov, V. V., Ponomareva, A. A., Zakyrjanova, G. F., Malomouzh, A. I., & Petrov, A. M. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01211-0 · Cited by 1
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Vassallo, J. D. (2012) · Cited by 1
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Metadata
- Authors
- Bauman, D. R., Bitmansour, A. D., McDonald, J. G., Thompson, B. M., Liang, G., & Russell, D. W.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Department of Molecular Genetics and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-09-29
- Volume
- 106
- Issue
- 39
- Pages
- 16764-16769
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2757821
- OpenAlex
- W2038363528
- Cited by
- 329
- References
- 34
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 19 · 2023: 26 · 2022: 16 · 2021: 21 · 2020: 30 · 2019: 28 · 2018: 27 · 2017: 19 · 2016: 21 · 2015: 13 · 2014: 19 · 2013: 18 · 2012: 21
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Welch Foundation (I-0971)
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 20848)
- National Institute of General Medical Sciences (U54GM069338, GM 069338)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 07745, T32DK007745)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- 25-hydroxycholesterol, oxysterols, macrophages, Toll-like receptor activation, immunoglobulin A, class switch recombination, activation-induced cytidine deaminase, B cell proliferation, cholesterol 25-hydroxylase, CYP7B1, negative regulation of immune response
- MeSH terms
- Animals, B-Lymphocytes, Hydroxycholesterols, Immunoglobulin A, Macrophages, Mice, Transgenic, Steroid Hydroxylases, Cytokines, Toll-Like Receptors, Mice
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