Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839

Epithelial–mesenchymal transitions in tumour progression

Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767

Involvement of chemokine receptors in breast cancer metastasis

Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340

Complex networks orchestrate epithelial–mesenchymal transitions

Thiery, J. P., & Sleeman, J. P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1835 · Cited by 3,947

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppé, J., Tong, F. K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.008 · Cited by 3,224

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

PETERSEN, O. W., Rønnov‐Jessen, L., Howlett, A. R., & Bissell, M. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9064 · Cited by 1,096

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

Kudo‐Saito, C., Shirako, H., Takeuchi, T., & Kawakami, Y. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.023 · Cited by 872

A novel human anti‐AXL monoclonal antibody attenuates tumour cell migration

Duan, Y., Luo, L., Qiao, C., Li, X., Wang, J., Liu, H., Zhou, T., Shen, B., Lv, M., & Feng, J. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12777 · Cited by 26

AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage

Pei, J., Wang, Y., Ma, L., Wang, X., Liu, L., Zhang, Y., Jin, R., Ren, Z., Deng, Y., Shen, J., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01047-6 · Cited by 26

Therapeutic Landscape of AXL Receptor Kinase in Triple-Negative Breast Cancer

Özyurt, R., & Özpolat, B. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0617 · Cited by 29

A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy

Claus, J., Patel, G. S., Ng, T., & Parker, P. J. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140043 · Cited by 26

Identification of copy number alterations associated with the progression of DCIS to invasive ductal carcinoma

Johnson, C., Gorringe, K. L., Er, T., Opeskin, K., Boyle, S., Wang, Y., Hill, P., Mann, G. B., & Campbell, I. (2012) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-10-s2-a93 · Cited by 26

Secrets of Drug Resistance in NSCLC Exposed by New Molecular Definition of EMT

Neel, D. S., & Bivona, T. G. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3232 · Cited by 26

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors

Tan, L., Zhang, Z., Gao, D., Chan, S., Luo, J., Tu, Z., Zhang, Z., Ding, K., Ren, X., & Lu, X. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.065 · Cited by 26

Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance

Jokela, T. A., Engelsen, A. S. T., Rybicka, A. M., Vatter, F. A. P., Garbe, J. C., Miyano, M., Tiron, C. E., Ferariu, D., Akslen, L. A., Stampfer, M. R., et al. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00041 · Cited by 25

AXL, an Important Host Factor for DENV and ZIKV Replication

Xie, S., Zhang, H., Liang, Z., Yang, X., & Cao, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.575346 · Cited by 25

Emerging Targets in Clear Cell Renal Cell Carcinoma

Chen, Y., Rini, B. I., & Beckermann, K. E. (2022) · Cancers · doi:10.3390/cancers14194843 · Cited by 25

Cells susceptible to epithelial-mesenchymal transition are enriched in stem-like side population cells from prostate cancer

Luo, Y., CUI, X., Zhao, J., HAN, Y., Li, M., Lin, Y., Jiang, Y., & Lan, L. (2013) · Oncology Reports · doi:10.3892/or.2013.2905 · Cited by 25

Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets

Konstantakou, E. G., Velentzas, A. D., Anagnostopoulos, A. K., Litou, Z. I., Konstandi, O. A., Giannopoulou, A. F., Anastasiadou, E., Voutsinas, G. E., Tsangaris, G. T., & Stravopodis, D. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171512 · Cited by 26

MicroRNA 34a–AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells

Lim, D., Cho, J. G., Yun, E., Lee, A., Ryu, H., Lee, Y. J., Yoon, S., Chang, W., Lee, M.-S., Kwon, B. S., et al. (2020) · Genes · doi:10.3390/genes12010009 · Cited by 25

Targeting AXL and the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Melanoma

Karlsen, K. F., McFadden, E., Omar, N., Haugen, M. H., Øy, G. F., Ryder, T., Gullestad, H. P., Hermann, R., Mælandsmo, G. M., & Flørenes, V. A. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-19-0290 · Cited by 24

Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor

Zhang, H., Xia, P., Dai, Y., Shao, J., Ji, Y., Sun, Y., Liu, B., Xu, C. W., Ai, J., & Duan, W. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02093 · Cited by 24

Research Progress on Therapeutic Targeting of Cancer-Associated Fibroblasts to Tackle Treatment-Resistant NSCLC

Li, C., Qiu, Y., & Zhang, Y. (2022) · Pharmaceuticals · doi:10.3390/ph15111411 · Cited by 25

GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL

Liao, Y., Chuang, Y., Lin, H., Lin, N., Hsu, T.-W., Hsieh, S., Chen, S., Hung, J., Yang, H., Liang, J., et al. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13347 · Cited by 24

AXL – a new player in resistance to HER2 blockade

Adam‐Artigues, A., Arenas, E. J., Arribas, J., Prat, A., & Cejalvo, J. M. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102639 · Cited by 24

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

Tsai, W.-B., Long, Y., Park, J.-R., Chang, J. T., Liu, H., Rodriguez‐Canales, J., Savaraj, N., Feun, L. G., Davies, M. A., Wistuba, I. I., et al. (2015) · Oncogene · doi:10.1038/onc.2015.237 · Cited by 24

Comprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer

Lee, J., Galloway, R., Grandjean, G., Jacob, J., Humphries, J., Bartholomeusz, C., Goodstal, S. M., Lim, B., Bartholomeusz, G. A., Ueno, N. T., et al. (2015) · Journal of Cancer · doi:10.7150/jca.13266 · Cited by 24

Phosphotyrosine profiling of curcumin-induced signaling

Sathe, G. J., Pinto, S. M., Syed, N., Nanjappa, V., Solanki, H. S., Renuse, S., Chavan, S., Khan, A. A., Patil, A. H., Nirujogi, R. S., et al. (2016) · Clinical Proteomics · doi:10.1186/s12014-016-9114-0 · Cited by 24

3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines

Zhuang, Y., Li, X., Ge, C., Si, H., Cui, L., Gao, H., Duan, Y., & Zhai, H. (2014) · Molecular Diversity · doi:10.1007/s11030-014-9556-0 · Cited by 23

A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness

Barcelos, R. C., Pelizzaro‐Rocha, K. J., Pastre, J. C., Dias, M. P., Ferreira‐Halder, C. V., & Pilli, R. A. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.09.085 · Cited by 23

A web platform for the network analysis of high-throughput data in melanoma and its use to investigate mechanisms of resistance to anti-PD1 immunotherapy

Dreyer, F. S., Cantone, M., Eberhardt, M., Jaitly, T., Walter, L. M., Wittmann, J., Gupta, S. K., Khan, F. M., Wolkenhauer, O., Pützer, B. M., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.01.020 · Cited by 23

Cabozantinib (XL184) and R428 (BGB324) Inhibit the Growth of Esophageal Squamous Cell Carcinoma (ESCC)

Yang, P., Liu, Y., Chang, Y.-H., Lin, C.-C., Huang, P., Hua, K., Lee, J., & Hsieh, M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01138 · Cited by 23

Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling

Tanaka, M., Dykes, S. S., & Siemann, D. W. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10093-z · Cited by 22

Mesenchymal–epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate

Terragno, M., Vetrova, A., Semenov, O., Sayan, E., Kriajevska, M. V., & Tulchinsky, E. M. (2024) · Scientific Reports · doi:10.1038/s41598-023-50710-3 · Cited by 22

Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma

Woo, S. M., Min, K., Seo, S. U., Kim, S., Kubatka, P., Park, J., & Kwon, T. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133253 · Cited by 22

NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression

Wang, B., Liu, D.-C., Guo, Q., Han, X., Bi, X., Wang, H., Wu, Z., & Wu, W. (2020) · Cancer Management and Research · doi:10.2147/cmar.s239664 · Cited by 22

Coexpression of receptor tyrosine kinase AXL and EGFR in human primary lung adenocarcinomas

Wu, Z., Bai, F., Fan, L., Pang, W., Han, R., Wang, J., Liu, Y., Xia, Y., Duan, H., & Xing, L. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.08.014 · Cited by 21

The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

Khera, L., Vinik, Y., Maina, F., & Lev, S. (2021) · Life Science Alliance · doi:10.26508/lsa.202000985 · Cited by 21

Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?

Dransfield, I., & Farnworth, S. L. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-39406-0_5 · Cited by 22

The Role of MicroRNAs upon Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

Boros, É., & Nagy, I. (2019) · Cells · doi:10.3390/cells8111461 · Cited by 21

The Tyrosine Kinome Dictates Breast Cancer Heterogeneity and Therapeutic Responsiveness

Ha, J. R., Siegel, P. M., & Ursini‐Siegel, J. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25561 · Cited by 20

Gas6 expression is reduced in advanced breast cancers

Ibrahim, A. M., Gray, Z., Gomes, A. M., Myers, L., Behbod, F., & Machado, H. L. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-0116-z · Cited by 20

Two-Front War on Cancer—Targeting TAM Receptors in Solid Tumour Therapy

Mikołajczyk, A., Mituła, F., Popiel, D., Kaminska, B., Wieczorek, M., & Pieczykolan, J. (2022) · Cancers · doi:10.3390/cancers14102488 · Cited by 20

Recent discovery and development of AXL inhibitors as antitumor agents

Liu, Z., Chen, L., Zhang, J., Yang, J. Y., Xiao, X., Shan, L., & Mao, W. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116475 · Cited by 20

Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer

Song, X., Akasaka, H., Wang, H., Abbasgholizadeh, R., Shin, J., Zang, F., Chen, J., Logsdon, C. D., Maitra, A., Bean, A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012186 · Cited by 20

Role of ELMO1 in inflammation and cancer—clinical implications

Tocci, S., Ibeawuchi, S., Das, S., & Sayed, I. M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00680-x · Cited by 20

Exploring mechanisms of acquired resistance to HER2 (human epidermal growth factor receptor 2)-targeted therapies in breast cancer

Creedon, H., Byron, A., Main, J., Hayward, L., Klinowska, T. C. M., & Brunton, V. G. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140109 · Cited by 19

TAM receptors: A phosphatidylserine receptor family and its implications in viral infections

Roy, S. G. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.09.003 · Cited by 19

Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency

Son, M., Seol, B., Han, Y., & Cho, Y. S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt571 · Cited by 19

MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells

Lee, C. J., Hsu, L., Yue, C.-H., Lin, H., Chiu, Y.-W., Lin, Y.-Y., Huang, C., Hung, M., & Liu, J.-Y. (2016) · Oncotarget · doi:10.18632/oncotarget.11337 · Cited by 19

An integrated approach of bioinformatic prediction and in vitro analysis identified that miR-34a targets MET and AXL in triple-negative breast cancer

Yazdi, S. H., Paryan, M., & Mohammadi‐Yeganeh, S. (2018) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-018-0116-y · Cited by 19

Biomarkers of epithelial-mesenchymal transition in localized, surgically treated clear-cell renal cell carcinoma

Gasińska, A., Jaszczyński, J., Adamczyk, A., Janecka-Widła, A., Wilk, W., Cichocka, A., & Stelmach, A. (2018) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2018.0023 · Cited by 19

Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant-KRas NSCLC Models

Haley, J. D., Haughney, E., Ullman, E., Bean, J. M., Haley, J. D., & Fink, M. Y. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00344 · Cited by 19

Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer

Mitra, D., Saha, D., Das, G., Mukherjee, R., Banerjee, S., Alam, N., Mustafi, S. M., Nath, P., Majumder, A., Majumder, B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108395 · Cited by 18

New Directions in the Study and Treatment of Metastatic Cancer

Yoo, B., Fuchs, B. C., & Medarova, Z. O. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00258 · Cited by 18

YKL-40/CHI3L1 facilitates migration and invasion in HER2 overexpressing breast epithelial progenitor cells and generates a niche for capillary-like network formation

Morera, E., Steinhäuser, S. S., Budková, Z., Ingþórsson, S., Kricker, J. A., Krueger, A., Traustadóttir, G. Á., & Guðjónsson, Þ. (2019) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-019-00403-x · Cited by 19

Detection of AXL expression in circulating tumor cells of lung cancer patients using an automated microcavity array system

Ikeda, M., Koh, Y., Teraoka, S., Sato, K., Kanai, K., Hayata, A., Tokudome, N., Akamatsu, H., Ozawa, Y., Akamatsu, K., et al. (2020) · Cancer Medicine · doi:10.1002/cam4.2846 · Cited by 18

Prognostic value and immunological role of AXL gene in clear cell renal cell carcinoma associated with identifying LncRNA/RBP/AXL mRNA networks

Wang, Y., Tian, Y., Liu, S., Wang, Z., & Xing, Q. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02322-y · Cited by 18

Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line

Ekyalongo, R. C., Mukohara, T., Kataoka, Y., Funakoshi, Y., Tomioka, H., Kiyota, N., Fujiwara, Y., & Minami, H. (2012) · Investigational New Drugs · doi:10.1007/s10637-012-9855-1 · Cited by 18

Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression

Sato, K., Suda, K., Shimizu, S., Sakai, K., Mizuuchi, H., Tomizawa, K., Takemoto, T., Nishio, K., & Mitsudomi, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154186 · Cited by 18

Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant BCR-ABL1+ cell lines

Liu, L., Kok, C. H., Saunders, V. A., Wang, J., McLean, J., Hughes, T. P., & White, D. L. (2018) · Oncotarget · doi:10.18632/oncotarget.26187 · Cited by 18

Greater utility of molecular subtype rather than epithelial‐to‐mesenchymal transition ( EMT ) markers for prognosis in high‐risk non‐muscle‐invasive ( HGT1 ) bladder cancer

Ottley, E., Pell, R., Brazier, B., Hollidge, J., Kartsonaki, C., Browning, L., O’Neill, E., & Kiltie, A. E. (2020) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.167 · Cited by 18

Mutant-Selective Irreversible EGFR Inhibitor, Naquotinib, Inhibits Tumor Growth in NSCLC Models with EGFR-Activating Mutations, T790M Mutation, and AXL Overexpression

Tanaka, H., Sakagami, H., Kaneko, N., Konagai, S., Yamamoto, H., Matsuya, T., Yuri, M., Yamanaka, Y., Mori, M., Takeuchi, M., et al. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0976 · Cited by 18

Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation

Poświata, A., Kozik, K., Miączyńska, M., & Zdżalik-Bielecka, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04312-3 · Cited by 17

Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer

Vanli, N., Sheng, J., Li, S., Xu, Z., & Hu, G. (2022) · Communications Biology · doi:10.1038/s42003-022-03597-1 · Cited by 17

Engineered Adoptive T-Cell Therapies for Breast Cancer: Current Progress, Challenges, and Potential

Chamorro, D. F., Somes, L. K., & Hoyos, V. (2023) · Cancers · doi:10.3390/cancers16010124 · Cited by 20

Design, Synthesis, and Validation of Axl-Targeted Monoclonal Antibody Probe for microPET Imaging in Human Lung Cancer Xenograft

Liu, S., Li, D., Guo, J., Canale, N., Li, X., Liu, R., Krasnoperov, V. G., Gill, P. S., Conti, P. S., Shan, H., et al. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500307t · Cited by 17

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

Ocal, O., Pashkov, V., Kollipara, R., Zolghadri, Y., Cruz, V. H., Hale, M. A., Heath, B. R., Artyukhin, A., Christie, A., Tsoulfas, P., et al. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.020933 · Cited by 21

Epithelial-to-Mesenchymal Transition and Phenotypic Marker Evaluation in Human, Canine, and Feline Mammary Gland Tumors

Sammarco, A., Gomiero, C., Beffagna, G., Cavicchioli, L., Ferro, S., Michieletto, S., Orvieto, E., Patruno, M., & Zappulli, V. (2023) · Animals · doi:10.3390/ani13050878 · Cited by 16

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

Tsugawa, H., Ohki, T., Tsubaki, S., Tanaka, R., Matsuzaki, J., Suzuki, H., & Hozumi, K. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011139 · Cited by 19

Subcritical Water Extracts from Agaricus blazei Murrill’s Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor

Yasuma, T., Toda, M., Kobori, H., Tada, N., D’Alessandro‐Gabazza, C. N., & Gabazza, E. C. (2021) · Journal of Fungi · doi:10.3390/jof7080590 · Cited by 16

Competitividad y teoria de la estrategia: un análisis aplicado a la cohabitación pyme-gran empresa.

Zornoza, C. C. (1996) · Dialnet (Universidad de la Rioja) · Cited by 16

Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers

Antony, J., Zanini, E., Birtley, J. R., Gabra, H., & Recchi, C. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0187-6 · Cited by 15

Development of 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents for the management of breast cancer

Meher, R. K., Pragyandipta, P., Reddy, P. K., Pedaparti, R., Kantevari, S., & Naik, P. K. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1982008 · Cited by 15

SNHG1/miR-194-5p/MTFR1 Axis Promotes TGFβ1-Induced EMT, Migration and Invasion of Tongue Squamous Cell Carcinoma Cells

Jia, Y., Chen, X., Zhao, D., & Ma, S. (2022) · Molecular Biotechnology · doi:10.1007/s12033-021-00445-1 · Cited by 15

Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics

LaBarge, M. A., Parvin, B., & Lorens, J. B. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.009 · Cited by 15

Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer

Lee, E., Ji, K.-Y., Kim, E., Kim, S., Song, H.-W., Choi, H.-R., Chung, B. Y., Choi, H. J., Bai, H., & Kang, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-05977-8 · Cited by 15

Role of the Receptor Tyrosine Kinase AXL in Hepatocellular Carcinoma and its Clinical Relevance

Niu, Z.-S., Niu, X.-J., & Wang, W. (2019) · Future Oncology · doi:10.2217/fon-2018-0528 · Cited by 15

Serum levels of inflammation‐related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers

Nome, M., Euceda, L. R., Jabeen, S., Debik, J., Bathen, T. F., Giskeødegård, G. F., Taskén, K. A., Mælandsmo, G. M., Halvorsen, B. L., Yndestad, A., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32638 · Cited by 15

Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate

Keung, W., Boloor, A., Brown, J., Kiryanov, A. A., Gangloff, A. R., Lawson, J. D., Skene, R. J., Hoffman, I., Atienza, J. M., Kahana, J. A., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.12.024 · Cited by 15

Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition

Genest, M., Comunale, F., Planchon, D., Govindin, P., Noly, D., Vacher, S., Bièche, I., Robert, B., Malhotra, H., Schoenit, A., et al. (2022) · Journal of Cell Science · doi:10.1242/jcs.259178 · Cited by 14

AXL as immune regulator and therapeutic target in Acute Myeloid Leukemia: from current progress to novel strategies

Vandewalle, N., Beule, N. D., Becker, A. D., Bruyne, E. D., Menu, E., Vanderkerken, K., Breckpot, K., Devoogdt, N., & Veirman, K. D. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00566-8 · Cited by 14

Protein kinase C α is involved in the regulation of AXL receptor tyrosine kinase expression in triple-negative breast cancer cells

Yue, C.-H., Liu, L., Kao, E., Lin, H., Hsu, L., Hsu, C.-W., Lin, Y.-Y., Lin, Y.-S., Liu, J.-Y., & Lee, C. J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5424 · Cited by 14

Targeting the AXL signaling pathway in ovarian cancer

Huang, R. Y., Antony, J., Tan, T. Z., & Tan, D. S. P. (2016) · Molecular & Cellular Oncology · doi:10.1080/23723556.2016.1263716 · Cited by 14

The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance

Davidsen, K. T., Haaland, G. S., Lie, M. K., Lorens, J. B., & Engelsen, A. S. T. (2017) · Springer eBooks · doi:10.1007/978-3-319-39147-2_15 · Cited by 14

Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells

Mayo, V., Bowles, A. C., Wubker, L., Ortiz, I., Cordoves, A. M., Côté, R. J., Correa, D., & Agarwal, A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220971599 · Cited by 15

Adaptive mechanisms of resistance to anti-neoplastic agents

Ferreira, B. I., Lie, M. K., Engelsen, A. S. T., Machado, S., Link, W., & Lorens, J. B. (2016) · MedChemComm · doi:10.1039/c6md00394j · Cited by 14

Ursolic Acid Inhibits Epithelial-Mesenchymal Transition through the Axl/NF- κ B Pathway in Gastric Cancer Cells

Li, J., Dai, C., & Shen, L. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2474805 · Cited by 14

Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells

Kurata, A., Tachibana, Y., Takahashi, T., & Horiba, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232055 · Cited by 14

Accurate Determination of Soluble Axl by Enzyme-Linked Immunosorbent Assay

Dengler, M., Huber, H., Müller, C. J., Zellmer, A., Rauch, P. J. G., & Mikulits, W. (2016) · Assay and Drug Development Technologies · doi:10.1089/adt.2016.743 · Cited by 14

Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy

Nordbø, O. P., Landolt, L. Z., Eikrem, Ø., Scherer, A., Leh, S. M., Furriol, J., Apeland, T., Mydel, P. M., & Marti, H. (2023) · Physiological Reports · doi:10.14814/phy2.15825 · Cited by 13

Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma

Repici, A., Ardizzone, A., Luca, F. D., Colarossi, L., Prestifilippo, A., Pizzino, G., Paterniti, I., Esposito, E., & Capra, A. P. (2024) · Cells · doi:10.3390/cells13040361 · Cited by 13

Increased tumor cell expression of Axl is a marker of aggressive features in breast cancer among African women

Ahmed, L., Nalwoga, H., Arnes, J. B., Wabinga, H., Micklem, D., & Akslen, L. A. (2015) · Apmis · doi:10.1111/apm.12403 · Cited by 13

Qigesan inhibits esophageal cancer cell invasion and migration by inhibiting Gas6/Axl-induced epithelial-mesenchymal transition

Kong, L., Lu, X., Chen, X., Wu, Y., Zhang, Y., Shi, H., & Li, J. (2020) · Aging · doi:10.18632/aging.103238 · Cited by 13

A microfluidic device for differential capture of heterogeneous rare tumor cells with epithelial and mesenchymal phenotypes

Wang, X., Deng, L., & Gjertsen, B. T. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.06.060 · Cited by 13

Exploring BODIPY-Based Sensor for Imaging of Intracellular Microviscosity in Human Breast Cancer Cells

Jurgutis, D., Jarockytė, G., Poderys, V., Dodonova‐Vaitkūnienė, J., Tumkevičius, S., Vyšniauskas, A., Rotomskis, R., & Karabanovas, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105687 · Cited by 13

Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

Efthymiou, V., Ding, L., Baláž, M., Sun, W., Balážová, L., Straub, L. G., Dong, H., Simon, E., Ghosh, A., Perdikari, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39715-8 · Cited by 13

Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy

Ponce, G. R. D. G., de Jalón, E. G., Stigen, E., Lund, K. B., Popa, M. L., Davidson, B., Safont, M. M., Rygh, C. B., Espedal, H., Barrett, T. M., et al. (2021) · Theranostics · doi:10.7150/thno.55092 · Cited by 13

Distinct mRNAs in Cancer Extracellular Vesicles Activate Angiogenesis and Alter Transcriptome of Vascular Endothelial Cells

Zhang, P., Lim, S. B., Jiang, K., Chew, T. W., Low, B. C., & Lim, C. T. (2021) · Cancers · doi:10.3390/cancers13092009 · Cited by 13

Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling

Park, J., Lee, C., Kim, H., Kim, D., Son, J. B., Ko, E., Cho, J.-H., Kim, N.-D., Nan, H., Kim, C.-Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13088 · Cited by 13

Gas6 is dispensable for pubertal mammary gland development

Mills, K. L., Gomes, A. M., Standlee, C. R., Rojo, M. D., Carmeliet, P., Lin, Z. N., & Machado, H. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208550 · Cited by 12

Royaume du Maroc

Benhima (1962) · Présence Africaine · doi:10.3917/presa.042.0147 · Cited by 13

Competing endogenous RNAs regulatory crosstalk networks: The messages from the RNA world to signaling pathways directing cancer stem cell development

Aria, H., Azizi, M., Nazem, S., Mansoori, B., Darbeheshti, F., Niazmand, A., Daraei, A., & Mansoori, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35208 · Cited by 12

Abstract B105: Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

Gjerdrum, C., Tiron, C. E., Høiby, T., Stefansson, I. M., Haugen, H., Sandal, T., Collet, K., Li, S., McCormack, E., Gjertsen, B. T., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-09-b105 · Cited by 1

Abstract 3308: Axl is required for EMT-induced stem cell traits and metastasis in breast cancer

Tiron, C. E., Stefansson, I. M., Haugen, H., Sandal, T., McCormack, E., Gjertsen, B. T., Micklem, D., Ivaska, J., Akslen, L. A., & Lorens, J. B. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3308

Abstract C76: Axl signaling is required for stem cell traits and metastasis in breast cancer

Tiron, C. E., Pelissier, F. A., Wnuk-Lipińska, K., Stefansson, I. M., Virtakoivu, R., Miyano, M., Sandal, T., Micklem, D., Garbe, J. C., Stampfer, M. R., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.tim2013-c76

Abstract 4888: Axl receptor signaling in required for stem cell traits and metastasis in breast cancer.

Tiron, C. E., Pelissier, F. A., Wnuk-Lipińska, K., Stefansson, I. M., Virtakoivu, R., Miyano, M., Sandal, T., Micklem, D., Garbe, J. C., Stampfer, M. R., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-4888

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

Goyette, M.-A., Duhamel, S., Aubert, L., Pelletier, A., Savage, P., Thibault, M.-P., Johnson, R. M., Carmeliet, P., Basik, M., Gaboury, L. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.019 · Cited by 148