Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839

Epithelial–mesenchymal transitions in tumour progression

Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767

Involvement of chemokine receptors in breast cancer metastasis

Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340

Complex networks orchestrate epithelial–mesenchymal transitions

Thiery, J. P., & Sleeman, J. P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1835 · Cited by 3,947

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppé, J., Tong, F. K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.008 · Cited by 3,224

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

PETERSEN, O. W., Rønnov‐Jessen, L., Howlett, A. R., & Bissell, M. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9064 · Cited by 1,096

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

Kudo‐Saito, C., Shirako, H., Takeuchi, T., & Kawakami, Y. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.023 · Cited by 872

A Hybrid Energy-Based and AI-Based Screening Approach for the Discovery of Novel Inhibitors of AXL

Lv, X., Kang, Y., Chi, X., Zhao, J., Pan, Z., Ying, X., Li, L., Pan, Y., Huang, W., & Wang, L. (2025) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.4c00511 · Cited by 1

Dual inhibition of AXL and MER kinase: scope for lung and breast cancer therapeutics

Sathe, B. D., Kumari, P., Kumar, H., Mane, M. S., Mudududdla, R., Baell, J. B., Kumar, R., Singh, S., Pawar, D. K., Kommi, D. N., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108824 · Cited by 1

Translational insights and clinical challenges of targeting cancer stem cells

Ahmed, M., Al-Haidari, A., Agarwal, S., Sun, J., Hammarlund, E. U., Rönnstrand, L., Pienta, K. J., Tatlı, Ö., & Kazi, J. U. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02887-y · Cited by 1

Isolation, in vitro cytotoxicity and in silico analysis of methoxylated flavone derivatives from Kaempferia parviflora on breast cancer cell lines

Aidiel, M., & Mutalib, M. A. (2026) · Scientific Reports · doi:10.1038/s41598-026-66144-6 · Cited by 1

Possible Disease-Link Genetic Pathways Constructed by Hierarchical Clustering and Conditional Probabilities of Ovarian Carcinoma Microarray Data

Ko, H.-H., Tseng, K.-J., Wei, L., & Tsai, M.-H. (2010) · International Conference on Intelligent Information Hiding and Multimedia Signal Processing (IIH-MSP) · doi:10.1109/iihmsp.2010.8 · Cited by 1

The Tumor Microenvironment in Cutaneous Melanoma: Friend or Foe

Straume, O., & Schuster, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-39147-2_21 · Cited by 1

Drivers of EMT and Immune Evasion

Brekken, R. A., & Wnuk-Lipińska, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-39147-2_9 · Cited by 1

Molecular Characterization of the Recombinant Ig1 Axl Receptor Domain: An Intriguing Bait for Screening in Drug Discovery

Stasi, R. D., Rosa, L. D., Izzi, G., & D’Andrea, L. D. (2024) · Molecules · doi:10.3390/molecules29020521 · Cited by 1

TAM family proteins and therapy resistance

McDaniel, N. K., Fischbach, S. R., Ondracek, O. J., Welke, N. B., Iida, M., & Wheeler, D. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817868-3.00008-1 · Cited by 1

Molecular organization of cells

Ahlstrom, J. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00006-x · Cited by 1

Drivers of EMT and Immune Evasion

Brekken, R. A., & Wnuk-Lipińska, K. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_11 · Cited by 1

Anticancer effect of superoxide dismutase on canine mammary gland tumour in vitro

Ko, B., An, J., Lee, J., Kim, K., Kim, T., Park, S., Chae, H., & Youn, H. (2023) · Veterinary Medicine and Science · doi:10.1002/vms3.1323 · Cited by 1

Molecular Organization of Cells

Ahlstrom, J. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10001-x · Cited by 1

Cancer exosomes harbor diverse hypoxia-targeted mRNAs and contribute toward tumor angiogenesisPreprint

Zhang, P., Lim, S. B., Jiang, K., Chew, T. W., Low, B. C., & Lim, C. T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.12.147850 · Cited by 1

Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbationsPreprint

Creixell, M., Taylor, S. D., Gerritsen, J. S., Bae, S. Y., Jiang, M., Augustin, T., Loui, M., Boixo, C., Creixell, P., White, F. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.20.563266 · Cited by 1

Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication

Liu, Y., & Liu, S. (2013) · Springer eBooks · doi:10.1007/978-94-007-6262-6_17

Gene signatures and prognostic factors in endometrial cancer. A study with special focus on vascular invasion

Mannelqvist, M. (2011) · NORA - Norwegian Open Research Archives

Identifiying oncogenic drivers in NSCLC cells harboring EGFR kinase domain mutation with resistance to EGFR TKI and mesenchymal phenotype

Gao, Y. (2014)

THE ROLE OF RECEPTOR TYROSINE KINASE AXL IN PANCREATIC DUCTAL ADENOCARCINOMA AND ITS REGULATION BY HEMATOPOIETIC PROGENITOR KINASE 1

Song, X. (2011) · Digital Commons-TMC (Texas Medical Center)

Endocrine Resistance and Epithelial Mesenchymal Transition in Breast Cancer

Al, S., & Yunus, A. (2011) · InTech eBooks · doi:10.5772/20707

The Soluble Form of the Axl Receptor Tyrosine Kinase

Ekman, C. J. (2010) · Lund University Publications (Lund University)

Axl RTK and microRNAs in urogenital cancers

Fritz, H. (2015) · Lund University Publications (Lund University)

Killer targets in metastasis

Donner, A. L. (2014) · Science-Business eXchange · doi:10.1038/scibx.2014.274

BIOLOGICAL MECHANISMS IN OVARIAN CARCINOGENESIS INITIATION AND PROGRESSION

Lozneanu, L. (2013)

Anchor or Accelerate – A Study on Cancer Cell Adhesion and Motility

Vuoriluoto, K. (2010) · UTUPub (University of Turku)

The role of Axl in melanoma metastasis

Kang, J. (2015) · NORA - Norwegian Open Research Archives

801: Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors − suggestion of combination therapy

Torka, R., Pénzes, K., Baumann, C., Gusenbauer, S., Szabadkai, I., Őrfi, L., Kéri, G., & Ullrich, A. (2014) · European Journal of Cancer · doi:10.1016/s0959-8049(14)50706-x

Study of Molecular Mechanisms of Sensitivity and Resistance to EGFR-Targeted Therapy in Lung Cancer

Zhang, Z. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

The role of TAM receptors in brain tumour cell signalling and behaviour

Vouri, M. (2016)

Use of genetically engineered mouse models in preclinical drug development

Creedon, H. (2015) · ERA

In Silico Approach to Identify Potential Inhibitors for Axl-Gas6 Signaling

Peter, S. C., Mannu, J., & Mathur, P. P. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6740-7_17

Metastatic Cutaneous Squamous Cell Carcinomas

García‐Díez, I., & Toll, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804003-4.00011-6

Immuntherapie gegen Tumorstammzellen bei Plattenepithelkarzinomen im Kopf-Hals-Bereich

Coordes, A., Ochsenreither, S., Qian, X., Hofmann, V. M., Meyer, J., Hoffmann, T. K., Kaufmann, A. M., & Albers, A. E. (2017) · Laryngo-Rhino-Otologie · doi:10.1055/s-0043-101698

Estudo da frequência relativa e participação de subpopulações de células-tronco de câncer no processo de metástase em carcinoma epidermóide de boca

Lopes, N. M. (2016) · doi:10.11606/d.25.2016.tde-02052017-184631

Estudos da formação de protoporfirina IX induzida por ácido aminolevulínico: um enfoque para o aprimoramento da Terapia Fotodinâmica

Rodrigues, P. G. S. (2017) · doi:10.11606/t.76.2017.tde-13032017-154358

Receptor Tyrosine Kinase AXL is a Potential Therapeutic Target in Muscle-Invasive Bladder Cancer

Al-Mahmoodi, H. (2018) · Leicester Research Archive (University of Leicester)

AXL receptor tyrosine kinase regulates Apolipoprotein E expression

Zhao, W. (2019) · cIRcle (University of British Columbia) · doi:10.14288/1.0372324

Intratumor heterogeneity in epithelial cancer: Assessment in cell line models and circulating tumor cells

Dinutanayo, W. W., Keilholz, I. T., & Braunholz, D. (2019) · Makara Journal of Health Research · doi:10.7454/msk.v23i1.10149

Molecular Organization of Cells

Ahlstrom, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398358-9.00008-2

Molecular Organization of Cells

Ahlstrom, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00006-8

Metastatic cancer: How one can address the therapeutic challenge

Jain, S., Raza, K., Agrawal, A. K., & Vaidya, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817846-1.00023-0

508 Different neoantigen expression patterns impact the strength of anti-tumor immune responses

Nguyen, K. B., Spranger, S., & Copeland, C. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-sitc2020.0508

Statistical Modeling of High-throughput Sequencing Data and Spatially Resolved Transcriptomic Data

Yin, S. (2020) · SMU Scholar (Southern Methodist University)

Sevoflurane Modulates Akt Isoforms In Triple Negative Breast Cancer Cell LinePreprint

Tiron, C. E., Pătrășcanu, E., Postu, P. A., Văcărean-Trandafir, I.-C., Tiron, A., & Grigoraș, I. (2020) · doi:10.21203/rs.3.rs-21784/v1

Application of CRISPR-Cas9 to interrogate novel gene functions in cutaneous melanoma

Matsuyama, L. S. A. S. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2021.tde-23022022-155211

AXL

Halmos, B., & Liu, X. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6613-0_114-1

Molecular Organization of Cells

Ahlstrom, J. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809880-6.00001-1

Epithelial Plasticity in Castration-Resistant Prostate Cancer: Biology of the Lethal Phenotype

Armstrong, A. J. (2014) · doi:10.21236/ada612312

AXL

Halmos, B., & Liu, X. (2017) · Springer eBooks · doi:10.1007/978-1-4419-0717-2_114

The Role of AXL Receptor Tyrosine Kinase in Cancer Cell Plasticity and Therapy Resistance

Lotsberg, M. L., Davidsen, K. T., Peters, S. D., Haaland, G. S., Rayford, A. J., Lorens, J. B., & Engelsen, A. S. T. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_18

Níveis De Expressão Gênica Das Semaforinas 3A E 4D No Reparo Ósseo Alveolar De Ratos Normo E Hiperglicemicos

Redondo, G. M., Malta, F. S., da Silva, V. S., & Bastos, M. F. (2021) · Colloquium health and education · doi:10.37497/colloquium.v1i2.12

The role of the ROBO 3 signaling pathway in pancreatic cancer plasticity

Krebs, N. (2022) · doi:10.53846/goediss-9412

Role of epithelial to mesenchymal transition in the resistant mechanism of EGFR-TKIs

Adachi, Y., & Ebi, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822833-3.00005-x

Supplementary Methods and References from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Kirane, A., Ludwig, K. F., Sorrelle, N. B., Haaland, G. S., Sandal, T., Ranaweera, R., Toombs, J. E., Wang, M., Dineen, S. P., Micklem, D., et al. (2023) · doi:10.1158/0008-5472.22405364

Data from Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Antitumor Immunity

Davra, V., Kumar, S., Geng, K., Calianese, D. C., Mehta, D., Gadiyar, V., Kasikara, C., Lahey, K. C., Chang, Y., Wichroski, M. J., et al. (2023) · doi:10.1158/0008-5472.c.6512515.v1

Data from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer

Zhang, Y., Arner, E. N., Rizvi, A., Toombs, J. E., Huang, H., Warner, S. L., Foulks, J. M., & Brekken, R. A. (2023) · doi:10.1158/1535-7163.c.6543388

Data from WNK1 Enhances Migration and Invasion in Breast Cancer Models

Jaykumar, A. B., Jung, J.-U., Parida, P. K., Dang, T. T., Wichaidit, C., Kannangara, A. R., Earnest, S. A., Goldsmith, E. J., Pearson, G. W., Malladi, S., et al. (2023) · doi:10.1158/1535-7163.c.6543072

Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers

Zammarchi, F., Havenith, K., Chivers, S., Hogg, P., Bertelli, F., Tyrer, P. J., Janghra, N., Reinert, H. W., Hartley, J. A., & van Berkel, P. H. (2023) · doi:10.1158/1535-7163.c.6543352

Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers

Zammarchi, F., Havenith, K., Chivers, S., Hogg, P., Bertelli, F., Tyrer, P. J., Janghra, N., Reinert, H. W., Hartley, J. A., & van Berkel, P. H. (2023) · doi:10.1158/1535-7163.c.6543352.v1

Data from AXL Is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer

Du, W., Phinney, N. Z., Huang, H., Wang, Z., Westcott, J. M., Toombs, J. E., Zhang, Y., Beg, M. S., Wilkie, T. M., Lorens, J. B., et al. (2023) · doi:10.1158/1541-7786.c.6545003.v1

Advances in targets in inflammatory breast cancer

Iwase, T., Wang, X., Phi, L. T., Sridhar, N., Ueno, N. T., & Lee, J. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2023.10.005

Aberrant activation of AXL may drive progression of squamous cell carcinoma in CLL patients: a mechanistic study with clinical implications

Sinha, S., Guo, R., Busso, M. D. D., Han, W., Boysen, J. C., Wellik, L. E., Ghosh, A. K., & Kay, N. E. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02752-1

Effect of silibinin on GAS6/sAXL and JAK/STAT pathways in human cholangiocarcinoma cell line

Caliskan, Z. N., Özel, M., Başkol, M., & Başkol, G. (2024) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2022-0275

Axl inhibition on dendritic cells enhances STING anticancer therapy through type I interferon signalingPreprint

Aguilera, T. A., Gonzalez, I., Elghonaimy, E. A., Zhang, Q., Montgomery, I., Leung, P. Q., Rodriguez, A., Diegeler, S., Swancutt, K. L., & Brekken, R. A. (2025) · Research Square · doi:10.21203/rs.3.rs-5569516/v1

Reduced expression of insulin like growth factor-2 mRNA binding protein 2 (IMP2) elevates TAZ via IMP3 in triple-negative breast cancer

Parimita, S., Das, A., & Samanta, S. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102209

Vestigial-like family member 1 (VGLL1): An emerging candidate in tumor progression

Parimita, S., Das, A., & Samanta, S. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151889

Paratope mapping of tilvestamab, an anti-AXL function-blocking antibody, using high-throughput bacterial expression of secreted scFv-osmY fusion proteins

Christakou, E., Kursula, P., & Micklem, D. (2025) · Bioscience Reports · doi:10.1042/bsr20253747

Dual Therapeutic Impact of AXL Inhibitor AB-329: Chemotherapy Sensitization and Immune Microenvironment Reprogramming in TNBC

Rampa, D. R., Fuson, J. A., Liu, H., Pan, M., Qin, Y., Deng, Y., Ueno, N. T., & Lee, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188896

Additional file 2 of Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation

Wei, C., & Li, X. (2020) · Figshare · doi:10.6084/m9.figshare.13167179

Additional file 3 of Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation

Wei, C., & Li, X. (2020) · Figshare · doi:10.6084/m9.figshare.13167182

Additional file 1 of Verteporfin inhibits cell proliferation and induces apoptosis in different subtypes of breast cancer cell lines without light activation

Wei, C., & Li, X. (2020) · Figshare · doi:10.6084/m9.figshare.13167176

Identification et optimisation de nouvelles séries chimiques anti-kinases

Feneyrolles, C. (2014) · theses.fr (ABES) · doi:10.70675/2ec89e77zde93z4684zbd60zb6f7afa532b9

Signalisation et ciblage thérapeutique du récepteur tyrosine kinase AXL dans les cancers

Leconet, W. (2014) · theses.fr (ABES) · doi:10.70675/e91475a6z3b26z42ecza153zdc13a97fb5ec

Caractérisation de sous-populations enrichies en cellules souches cancéreuses et rôle des régulateurs de la transition épithélio-mésenchymateuse dans la plasticité tumorale dans le cancer du sein de type basal

Houhou, M. (2017) · theses.fr (ABES) · doi:10.70675/e925ba39z07ddz48e1zbd0dzf119cc8cbb50

Rôle de la surexpression des flotillines dans l'activation de voie de signalisation oncogéniques induisant la transition épithélio-mésenchymateuse

Genest, M. (2019) · theses.fr (ABES) · doi:10.70675/6205aed7zc520z4b11z8e40z67496f353e4b

Impact du ciblage du domaine de liaison de HIF-1α avec HIF-1β sur le paysage immunitaire du mélanome

Lequeux, A. (2020) · theses.fr (ABES) · doi:10.70675/a29d12dbz79c1z4d37za978z2e2319131c82

Neoplastic mast cells from patients with mastocytosis express AXL : effects on proliferation, apoptosis, and resistance to tyrosine kinase inhibitors

Kangboonruang, K. (2024) · theses.fr (ABES) · doi:10.70675/52e86990z6280z43a5zbab1z4fb14a321c87

Harnessing the chemical reactivity of metals and related supramolecular structures in cancer cells and inflammation

Baron, L. (2024) · theses.fr (ABES) · doi:10.70675/ae08925dz4e9ez4a38z90dez1db0baa83cc1

N-Glycosylation of AXL Receptor Tyrosine Kinase Regulates Its Stability, Phosphorylation, and Oncogenic Function

Wang, L., Li, L., Wang, J., Garapati, K., Li, F., Khan, M. K. H., Kong, X., Bakshi, H., Jiang, D., Zheng, S., et al. (2026) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2026.101574

Structure-Based Drug Discovery of Triazine Derivatives as Potent and Orally Bioavailable AXL Inhibitors for Cancer Therapy

Sun, M., Wu, S., Zhong, Y., Xi, N., & 曹迁永 (2026) · ACS Omega · doi:10.1021/acsomega.6c04179

The promising role of flavonoids in inhibiting epithelial to mesenchymal transition

Kashyap, D., Sharma, R., Munda, V. S., Garg, V. K., Thakur, S., Sharma, D., Okpala, C. O. R., & Dhiman, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-42855-5.00010-8

Redefining first-line standards: The role of next-generation HER2-Targeted therapies in HER2-positive metastatic breast cancer

Zhang, L. J., Li, H., Sun, S., Li, N., Zhao, S., Zhao, Z., & Li, M. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189649

AXL phosphosite mapping links FAK1 and YAP1 signaling to erlotinib resistance in EGFR-mutant lung cancer

Creixell, M., Taylor, S. D., Gerritsen, J. S., Jiang, M., Bae, S. Y., Augustin, T., Loui, M., Boixo, C., Minamino, S., Gong, V., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117717

AXL at the nexus of therapeutic resistance, tumor vascularization, and immune evasion in cancer

Hoffman, H. L., Handorf, K. M. V., Behrmann, C. A., Lathia, J. D., & Plas, D. R. (2026) · iScience · doi:10.1016/j.isci.2026.117552

Tumour extrinsic neutrophil regulation in mesothelioma correlates with responsiveness to AXL and PD1 inhibition in MIST3, a phase IIA clinical trialPreprint

Fennell, D. A., Działo, J., Zhang, M., Bzura, A., Poile, C., Baitei, E. Y., Dungey, M. R., Branson, A., King, A., Barber, S. R., et al. (2026) · medRxiv · doi:10.64898/2026.09.22.26363540

A Multi-Kinase Inhibitor Screen Identifies mTOR Signaling as a Vulnerability in Advanced Prostate CancerPreprint

Sridhar, S., Mohan, K., Kizhake, S., Natarajan, A., Kelly, D. L., & Mathew, G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.13.758818

Distinct ROS-adaptive and OXPHOS-dependent cellular programs underlie Ewing sarcoma heterogeneity

Sabapathy, Y., Subramani, J., & Gopisetty, G. (2026) · Journal of Proteomics · doi:10.1016/j.jprot.2026.105752

BindingDB Entry 50023345: A Hybrid Energy-Based and AI-Based Screening Approach for the Discovery of Novel Inhibitors of AXL.

BindingDB (2026) · UC San Diego · doi:10.7270/q2vq37k8

BindingDB Entry 50049093: Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate.

BindingDB (2019) · UC San Diego · doi:10.7270/q2d50q6f

BindingDB Entry 50013982: Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.

BindingDB (2022) · UC San Diego · doi:10.7270/q2pr80sr

BindingDB Entry 50039496: Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

BindingDB (2013) · UC San Diego · doi:10.7270/q24j0g4z

BindingDB Entry 50047507: AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective.

BindingDB (2017) · UC San Diego · doi:10.7270/q24m96fs

BindingDB Entry 50020942: Recent discovery and development of AXL inhibitors as antitumor agents.

BindingDB (2025) · UC San Diego · doi:10.7270/q2z89j03

BindingDB Entry 50009846: 4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.

BindingDB (2021) · UC San Diego · doi:10.7270/q2n301fs

BindingDB Entry 50014516: Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation.

BindingDB (2022) · UC San Diego · doi:10.7270/q2cr5z5b

Abstract B105: Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

Gjerdrum, C., Tiron, C. E., Høiby, T., Stefansson, I. M., Haugen, H., Sandal, T., Collet, K., Li, S., McCormack, E., Gjertsen, B. T., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-09-b105 · Cited by 1

Abstract 3308: Axl is required for EMT-induced stem cell traits and metastasis in breast cancer

Tiron, C. E., Stefansson, I. M., Haugen, H., Sandal, T., McCormack, E., Gjertsen, B. T., Micklem, D., Ivaska, J., Akslen, L. A., & Lorens, J. B. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3308

Abstract C76: Axl signaling is required for stem cell traits and metastasis in breast cancer

Tiron, C. E., Pelissier, F. A., Wnuk-Lipińska, K., Stefansson, I. M., Virtakoivu, R., Miyano, M., Sandal, T., Micklem, D., Garbe, J. C., Stampfer, M. R., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.tim2013-c76

Abstract 4888: Axl receptor signaling in required for stem cell traits and metastasis in breast cancer.

Tiron, C. E., Pelissier, F. A., Wnuk-Lipińska, K., Stefansson, I. M., Virtakoivu, R., Miyano, M., Sandal, T., Micklem, D., Garbe, J. C., Stampfer, M. R., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-4888

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

Goyette, M.-A., Duhamel, S., Aubert, L., Pelletier, A., Savage, P., Thibault, M.-P., Johnson, R. M., Carmeliet, P., Basik, M., Gaboury, L. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.019 · Cited by 148