The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
Open accessAbstract
Circadian clock genes are regulated by glucocorticoids; however, whether this regulation is a direct or secondary effect and the physiological consequences of this regulation were unknown. Here, we identified glucocorticoid response elements (GREs) at multiple clock genes and showed that 3 were directly regulated by the glucocorticoid receptor. We determined that a GRE within the core clock gene Per2 was continuously occupied during rhythmic expression and essential for glucocorticoid regulation of that gene in vivo. We further demonstrated that mice with a genomic deletion spanning this GRE expressed elevated leptin levels and were protected from glucose intolerance and insulin resistance on glucocorticoid treatment but not from muscle wasting. We conclude that Per2 is an integral component of a particular glucocorticoid regulatory pathway and that glucocorticoid regulation of the peripheral clock is selectively required for some actions of glucocorticoids.
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“Resetting of the peripheral clock occurs through well-defined molecular mechanisms that involve direct interaction of glucocorticoids, glucocorticoid response elements and the regulatory regions of core clock genes Bmal1, Cry1, Per1 and Per2 [63, 64].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [64]
Experimental — accuracy not yet measuredIn the citing paper
“Per2 null mice exhibit no glucocorticoid oscillations, indicating that PER2 may also impact glucocorticoid receptor (GR)-dependent glucose metabolism [24,25].”
From Circadian control of glucose metabolism (2014) · cites this paper as [24]
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Citations
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214
Phinney, D. G., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0637 · Cited by 1,910
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,850
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Items 401–427 of 427
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570851
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570866
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570836
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570857
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570845
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570863
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570848
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570869
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570875
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570860
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570872
Ybañez, W. S., & Bagamasbad, P. (2024) · Figshare · doi:10.6084/m9.figshare.26570839
Viotto, E. V., Iugman, J., Valli, F. E., Pierini, S. E., Simoncini, M. S., Somoza, G. M., & Piña, C. I. (2026) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.70062
Semenovykh, D., Semenovykh, K., Sládek, M., & Sumová, A. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01152-8
“For example, glucocorticoids increase the expression of Per2 by binding to its intronic sequence in mouse primary marrow stromal cells [68].”
Hanus, P., Frydecka, D., & Ślęzak, M. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70394 · Cited by 1
“GCs plasma concentration oscillates in circadian manner, serving as a principal mechanism that couples energy balance and expenditure with organism's activity (So et al. 2009; Kuo et al. 2015).”
Sleep, Circadian Rhythms, and Male Reproduction
Liu, P. Y. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_64-1
The role of the circadian transcription factor KLF10 in liver physiology
Ruberto, A. A. (2019) · theses.fr (ABES) · doi:10.70675/cb3492c2z5778z48e3za7d7zf17279fd718b
Glucocorticoid receptor activity in triple negative breast cancer
Noureddine, L. M. (2022) · theses.fr (ABES) · doi:10.70675/13ab50cfz7edbz4a44z918aza657b9614a4d
Ge, F., Yu, L., Sun, Y., Chen, Y., Du, J., Dong, M., Gu, L., Ding, Y., Zhu, H., Liu, S., et al. (2026) · Gene · doi:10.1016/j.gene.2026.150162
Samorì, E., Frigato, E., Valle, L. D., Tesoriere, A., Sánchez‐Vázquez, F. J., López‐Olmeda, J. F., & Bertolucci, C. (2026) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2026.112018
Morena, F., Viggars, M. R., Bohmke, N. J., Ewachiw, T. E., & Esser, K. A. (2026) · Life Metabolism · doi:10.1093/lifemeta/loag021
Zhang, A., Meng, C., Liu, Q., Shi, Q., Cao, A., Chen, Q., & Jia, Y. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107549
“…GC serve as established hormonal cues that entrain peripheral oscillators (Shimba and Ikuta, 2020), and GC response elements participate in the transcriptional regulation of clock-and bile acid – related genes (Mitropoulos and Balasubramaniam, 1976; So, et al., 2009; Yamamoto, et al., 2005).”
Post-transcriptional glucocorticoid receptor signalling synchronises circadian rhythmsPreprint
Edmondson, A., Zeller, A., Ahlburg, J., Shlamovitz, I., Mihut, A., Beale, A. D., Franco, C., Smith, T., Barry, N., Boulanger, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.12.743743
Clocks and steroids interaction across the life span
Pilorz, V., Chang, P., Newbold, S. A., Nied, E., Simonneaux, V., Astiz, M., & Piggins, H. D. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70291
Metadata
- Authors
- So, A. Y.-L., Bernal, T. U., Pillsbury, M. L., Yamamoto, K. R., & Feldman, B. J.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-10-13
- Volume
- 106
- Issue
- 41
- Pages
- 17582-17587
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2757402
- OpenAlex
- W1998522501
- Cited by
- 431
- References
- 51
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 37 · 2023: 19 · 2022: 36 · 2021: 28 · 2020: 32 · 2019: 28 · 2018: 22 · 2017: 28 · 2016: 33 · 2015: 23 · 2014: 25 · 2013: 20 · 2012: 18
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- University of California, San Francisco
- National Cancer Institute (CA20535, R01CA020535, R37CA020535)
- National Institute of General Medical Sciences (R25GM056847, GM 56847)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK073697, DK73697)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- glucocorticoids, circadian clock, clock genes, glucocorticoid response element, glucocorticoid receptor, Per2, glucose homeostasis, insulin resistance, impaired glucose tolerance, leptin, muscle atrophy, peripheral clocks
- MeSH terms
- Animals, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Glucose, Homeostasis, Nuclear Proteins, Transcription Factors, Transcription, Genetic, Polymerase Chain Reaction, Cell Cycle Proteins, Leptin, Mice, Period Circadian Proteins, Mesenchymal Stem Cells
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