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Cited by 525

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Unique multipotent cells in adult human mesenchymal cell populations

Open access
Kuroda, Yasumasa, Kitada, Masaaki, Wakao, Shohei, Nishikawa, Kouki, Tanimura, Yukihiro, Makinoshima, Hideki, Goda, Makoto, Akashi, Hideo, Inutsuka, Ayumu, Niwa, Akira, Shigemoto, Taeko, Nabeshima, Yoko, Nakahata, Tatsutoshi, Nabeshima, Yo-ichi, Fujiyoshi, Yoshinori, Dezawa, Mari·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0911647107
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Abstract

We found adult human stem cells that can generate, from a single cell, cells with the characteristics of the three germ layers. The cells are stress-tolerant and can be isolated from cultured skin fibroblasts or bone marrow stromal cells, or directly from bone marrow aspirates. These cells can self-renew; form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency; and can differentiate into endodermal, ectodermal, and mesodermal cells both in vitro and in vivo. When transplanted into immunodeficient mice by local or i.v. injection, the cells integrated into damaged skin, muscle, or liver and differentiated into cytokeratin 14-, dystrophin-, or albumin-positive cells in the respective tissues. Furthermore, they can be efficiently isolated as SSEA-3(+) cells. Unlike authentic ES cells, their proliferation activity is not very high and they do not form teratomas in immunodeficient mouse testes. Thus, nontumorigenic stem cells with the ability to generate the multiple cell types of the three germ layers can be obtained through easily accessible adult human mesenchymal cells without introducing exogenous genes. These unique cells will be beneficial for cell-based therapy and biomedical research.

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Metadata

Authors
Kuroda, Y., Kitada, M., Wakao, S., Nishikawa, K., Tanimura, Y., Makinoshima, H., Goda, M., Akashi, H., Inutsuka, A., Niwa, A., Shigemoto, T., Nabeshima, Y., Nakahata, T., Nabeshima, Y.-I., Fujiyoshi, Y., & Dezawa, M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2010-04-26
Volume
107
Issue
19
Pages
8639-8643
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0911647107
OpenAlex
W2009804171
Cited by
525
References
6
FWCI
12.88
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Unique multipotent cells in adult human mesenchymal cell populations. https://app.cochat.ai/papers/10.1073/pnas.0911647107
The paper
Kuroda, Y., Kitada, M., Wakao, S., Nishikawa, K., Tanimura, Y., Makinoshima, H., Goda, M., Akashi, H., Inutsuka, A., Niwa, A., Shigemoto, T., Nabeshima, Y., Nakahata, T., Nabeshima, Y.-I., Fujiyoshi, Y., & Dezawa, M. (2010). Unique multipotent cells in adult human mesenchymal cell populations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0911647107

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.