The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Identification of a microRNA signature of renal ischemia reperfusion injury
Open accessAbstract
Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality. Given the importance of microRNAs (miRNAs) in regulating gene expression, we examined expression profiles of miRNAs following renal IRI. Global miRNA expression profiling on samples prepared from the kidneys of C57BL/6 mice that underwent unilateral warm ischemia revealed nine miRNAs (miR-21, miR-20a, miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI when compared with sham controls. These miRNAs were also differently expressed following IRI in immunodeficient RAG-2/common γ-chain double-knockout mice, suggesting that the changes in expression observed are not significantly influenced by lymphocyte infiltration and therefore define a lymphocyte-independent signature of renal IRI. In vitro studies revealed that miR-21 is expressed in proliferating tubular epithelial cells (TEC) and up-regulated by both cell-intrinsic and -extrinsic mechanisms resulting from ischemia and TGF-β signaling, respectively. In vitro, knockdown of miR-21 in TEC resulted in increased cell death, whereas overexpression prevented cell death. However, overexpression of miR-21 alone was not sufficient to prevent TEC death following ischemia. Our findings therefore define a molecular fingerprint of renal injury and suggest miR-21 may play a role in protecting TEC from death.
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The functions of animal microRNAs
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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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Siedlecki, A., Irish, W., & Brennan, D. C. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03754.x · Cited by 817
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
TGF-β/Smad signaling in renal fibrosis
Meng, X.-M., Tang, P. M.-K., Li, J., & Lan, H. Y. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00082 · Cited by 666
MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways
Chau, B. N., Xin, C., Hartner, J., Ren, S., Castano, A. P., Linn, G., Li, J., Tran, P. T., Kaimal, V., Huang, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003205 · Cited by 587
Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis
Zhong, X., Chung, A. C. K., Chen, H.-Y., Meng, X.-M., & Lan, H. Y. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010111168 · Cited by 409
Metadata
- Authors
- Godwin, J. G., Ge, X., Stephan, K., Jurisch, A., Tullius, S. G., & Iacomini, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-07-22
- Volume
- 107
- Issue
- 32
- Pages
- 14339-14344
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2008971670
- Cited by
- 373
- References
- 8
- FWCI
- 18.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Godwin, J. G., Ge, X., Stephan, K., Jurisch, A., Tullius, S. G., & Iacomini, J. (2010). Identification of a microRNA signature of renal ischemia reperfusion injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0912701107
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