The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Open accessAbstract
Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of 7,8-dihydroxyflavone as a bioactive high-affinity TrkB agonist that provokes receptor dimerization and autophosphorylation and activation of downstream signaling. 7,8-Dihydroxyflavone protected wild-type, but not TrkB-deficient, neurons from apoptosis. Administration of 7,8-dihydroxyflavone to mice activated TrkB in the brain, inhibited kainic acid-induced toxicity, decreased infarct volumes in stroke in a TrkB-dependent manner, and was neuroprotective in an animal model of Parkinson disease. Thus, 7,8-dihydroxyflavone imitates BDNF and acts as a robust TrkB agonist, providing a powerful therapeutic tool for the treatment of various neurological diseases.
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Cites
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Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
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Psychedelics promote structural and functional neural plasticity
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GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration
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Metadata
- Authors
- Jang, S.-W., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., & Ye, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-01-25
- Volume
- 107
- Issue
- 6
- Pages
- 2687-2692
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006733352
- Cited by
- 686
- References
- 25
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Jang, S.-W., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., & Ye, K. (2010). A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0913572107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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