The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1
Open accessAbstract
Lactobacilli have long been regarded as important constituents of the healthy human vagina. Lactobacillus iners is the most frequently detected bacterial species in the vagina, but little is known about its characteristics. We report a description of the whole-genome sequence of L. iners AB-1 along with comparative analysis of published genomes of closely related strains of lactobacilli. The genome is the smallest Lactobacillus reported to date, with a 1.3-Mbp single chromosome. The genome seems to have undergone one or more rapid evolution events that resulted in large-scale gene loss and horizontal acquisition of a number of genes for survival in the vagina. L. iners may exhibit specialized adaptation mechanisms to the vaginal environment, such as an iron–sulfur cluster assembly system, and several unique σ factors to regulate gene transcription in this fluctuating environment. A potentially highly expressed homolog of a cholesterol-binding lysin may also contribute to host cell adhesion or act as a defense mechanism against other microbes. Notably, there is a lack of apparent adhesion proteins, but several cell-anchor proteins were identified and may be important for interaction with the host mucosal tissues. L. iners is widely present in healthy females as well as those suffering from bacterial vaginosis or who have undergone antimicrobial therapy, suggesting that it is an important indigenous species of the vagina.
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Cites
Molecular Identification of Bacteria Associated with Bacterial Vaginosis
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Genome-scale analyses of health-promoting bacteria: probiogenomics
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The Lactobacillus Anomaly: Total Iron Abstinence
Weinberg, E. D. (1997) · Perspectives in Biology and Medicine · doi:10.1353/pbm.1997.0072 · Cited by 176 · cited 1×
“Although iron is a required element for nearly all living organisms, it has commonly been accepted that lactobacilli do not require iron for growth and instead, use manganese and cobalt as cofactors for biological processes (36, 61).”
BackgroundIron requirement of Lactobacillus spp. in completely chemically defined growth media
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On the Iron Requirement of Lactobacilli Grown in Chemically Defined Medium
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Cited by
The Vaginal Microenvironment: The Physiologic Role of Lactobacilli
Amabebe, E., & Anumba, D. O. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00181 · Cited by 785
Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health
Petrova, M. I., Lievens, E., Malik, S., Imholz, N., & Lebeer, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00081 · Cited by 523
Mitra, A., MacIntyre, D. A., Marchesi, J. R., Lee, Y. S., Bennett, P. R., & Kyrgiou, M. (2016) · Microbiome · doi:10.1186/s40168-016-0203-0 · Cited by 484
The Vaginal Microbiota: What Have We Learned after a Decade of Molecular Characterization?
van de Wijgert, J. H. H. M., Borgdorff, H., Verhelst, R., Crucitti, T., Francis, S., Verstraelen, H., & Jespers, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105998 · Cited by 465
Lactobacillus iners : Friend or Foe?
Petrova, M. I., Reid, G., Vaneechoutte, M., & Lebeer, S. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2016.11.007 · Cited by 459
Self-citation
Metadata
- Authors
- Macklaim, J. M., Gloor, G. B., Anukam, K. C., Cribby, S., & Reid, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-11-08
- Volume
- 108
- Issue
- supplement_1
- Pages
- 4688-4695
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006934759
- Cited by
- 218
- References
- 8
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Macklaim, J. M., Gloor, G. B., Anukam, K. C., Cribby, S., & Reid, G. (2011). At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1000086107
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