Genome-scale analyses of health-promoting bacteria: probiogenomics
Abstract
The human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.
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The use of probiogenomics is revolutionizing the identification of novel probiotic strains.
“The use of probiogenomics is revolutionizing the identification of novel probiotic strains [19].”
From Women's health is a team effort: probiogenomics supports the development of a multi-species vaginal probiotic (2026) · cites this paper as [19]
Inflammation is closely associated with the presence or absence of these microbes (Clostridiales and Lactobacillaceae).
“Previous studies have shown a close association between inflammation and the presence or absence of these microbes, respectively,62–64”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [64]
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Candela, M., Biagi, E., Centanni, M., Turroni, S., Vici, M., Musiani, F., Vitali, B., Bergmann, S., Hammerschmidt, S., & Brigidi, P. (2009) · Microbiology · doi:10.1099/mic.0.028795-0 · Cited by 118 · see citing works
Comparative Genomics of Bifidobacterium, Lactobacillus and Related Probiotic Genera
Lukjančenko, O., Ussery, D. W., & Wassenaar, T. M. (2011) · Microbial Ecology · doi:10.1007/s00248-011-9948-y · Cited by 117 · see citing works
da Silva, T. F., Glória, R. D. A., Americo, M. F., Freitas, A. D. S., de Jesus, L. C. L., Barroso, F. A. L., Laguna, J. G., Coelho-Rocha, N. D., Tavares, L. M., le Loir, Y., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10247-x · Cited by 117 · see citing works
Wine, E., Gareau, M. G., Johnson‐Henry, K. C., & Sherman, P. M. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01781.x · Cited by 113 · see citing works
Structural basis for adaptation of lactobacilli to gastrointestinal mucus
Etzold, S., Coleman, O. I., MacKenzie, D. A., Tailford, L. E., Gunning, A. P., Walshaw, J., Hemmings, A. M., & Juge, N. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12377 · Cited by 111 · see citing works
Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
Sharma, V., Singh, T. G., Garg, N., Dhiman, S., Gupta, S., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomolecules · doi:10.3390/biom11050678 · Cited by 111 · see citing works
Probiotics: progress toward novel therapies for intestinal diseases
Yan, F., & Polk, D. B. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328335239a · Cited by 111 · see citing works
Ahlawat, S., Kumar, P., Mohan, H., Goyal, S., & Sharma, K. K. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1876631 · Cited by 111 · see citing works
Translating Omics to Food Microbiology
Walsh, A. M., Crispie, F., Claesson, M. J., & Cotter, P. D. (2017) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030216-025729 · Cited by 110 · see citing works
Self-citation
- Authors
- Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., van Sinderen, D., & O'Toole, P. W.
- Affiliations
- University of Parma (IT)
- University College Cork (IE)
- North Carolina State University (US)
- Venue
- Nature Reviews Microbiology
- Published
- 2008-11-24
- Volume
- 7
- Issue
- 1
- Pages
- 61-71
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2008054523
- Cited by
- 471
- References
- 90
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 31 · 2023: 18 · 2022: 29 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 21 · 2017: 32 · 2016: 22 · 2015: 25 · 2014: 25 · 2013: 35 · 2012: 34
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- probiogenomics, probiotic bacteria, human gut microbiome, Bifidobacterium, Lactobacillus, intestinal adaptation, dietary supplements, gut health
- MeSH terms
- Bifidobacterium, Humans, Lactobacillus, Probiotics, Genomics
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