Cited by 480Probiotics and Fermented FoodsGut microbiota and healthBacterial Genetics and Biotechnology

Genome-scale analyses of health-promoting bacteria: probiogenomics

Ventura, Marco, O'Flaherty, Sarah, Claesson, Marcus J., Turroni, Francesca, Klaenhammer, Todd R., van Sinderen, Douwe, O'Toole, Paul W.·2009·Nature Reviews Microbiology

Abstract

The human body is colonized by an enormous population of bacteria (microbiota) that provides the host with coding capacity and metabolic activities. Among the human gut microbiota are health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. Recent genomics-based studies (probiogenomics) are starting to provide insights into how probiotic bacteria sense and adapt to the gastrointestinal tract environment. In this Review, we discuss the application of probiogenomics in the elucidation of the molecular basis of probiosis using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples.

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Crossref · 10.1038/nrmicro2047

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Authors
Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., van Sinderen, D., & O'Toole, P. W.
Affiliations
  • University of Parma (IT)
  • University College Cork (IE)
  • North Carolina State University (US)
Venue
Nature Reviews Microbiology
Published
2008-11-24
Volume
7
Issue
1
Pages
61-71
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2008054523
Cited by
471
References
90
Citations by year
2026: 9 · 2025: 21 · 2024: 31 · 2023: 18 · 2022: 29 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 21 · 2017: 32 · 2016: 22 · 2015: 25 · 2014: 25 · 2013: 35 · 2012: 34
FWCI
4.29
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
  • Cork Open Research Archive (University College Cork, Ireland) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
probiogenomics, probiotic bacteria, human gut microbiome, Bifidobacterium, Lactobacillus, intestinal adaptation, dietary supplements, gut health
MeSH terms
Bifidobacterium, Humans, Lactobacillus, Probiotics, Genomics

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