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Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function
Open accessAbstract
N,N -Diethyl- m -toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females with males of unknown sensitivity over several generations resulted in two populations with different proportions of insensitive females. Crossing experiments showed the “insensitivity” trait to be dominant. Electroantennography showed a reduced response to DEET in the selected insensitive line compared with the selected sensitive line, and single sensillum recordings identified DEET-sensitive sensilla that were nonresponders in the insensitive line. This study suggests that behavioral insensitivity to DEET in A. aegypti is a genetically determined dominant trait and resides in changes in sensillum function.
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“The promising news is that there are several electrophysiological and behavioural assays with correspondingly robust analyses currently being used in vector biology research that could be incorporated into such schemes once adopted by WHOPES and the wider scientific community [16,36-42].”
From Spatial repellents: from discovery and development to evidence-based validation (2012) · cites this paper as [41]
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Metadata
- Authors
- Stanczyk, N. M., Brookfield, J. F. Y., Ignell, R., Logan, J. G., & Field, L. M.
- Affiliations
- University of Nottingham (GB)
- Swedish University of Agricultural Sciences (SE)
- Rothamsted Research (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-05-03
- Volume
- 107
- Issue
- 19
- Pages
- 8575-8580
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2889326
- OpenAlex
- W2000424479
- Cited by
- 138
- References
- 31
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 13 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 3 · 2014: 14 · 2013: 10 · 2012: 5
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rothamsted Repository (Rothamsted Repository) (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Svenska Forskningsrådet Formas (IC‐E3)
- Vetenskapsrådet
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect Pheromone Research and Control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- DEET, Aedes aegypti, sensilla, electroantennogram, dominant trait, mosquito olfaction, mosquito vectors
- MeSH terms
- Aedes, Animals, Animal Structures, Behavior, Animal, Crosses, Genetic, DEET, Female, Insecticide Resistance, Male, Selection, Genetic, Olfactory Receptor Neurons, Quantitative Trait, Heritable
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