The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray
Open accessAbstract
Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum ( Pf ). Despite the enormous worldwide burden of malaria, the targets of protective Abs and the basis of their inefficient acquisition are unknown. Addressing these knowledge gaps could accelerate malaria vaccine development. To this end, we developed a protein microarray containing ∼23% of the Pf 5,400-protein proteome and used this array to probe plasma from 220 individuals between the ages of 2–10 years and 18–25 years in Mali before and after the 6-month malaria season. Episodes of malaria were detected by passive surveillance over the 8-month study period. Ab reactivity to Pf proteins rose dramatically in children during the malaria season; however, most of this response appeared to be short-lived based on cross-sectional analysis before the malaria season, which revealed only modest incremental increases in Ab reactivity with age. Ab reactivities to 49 Pf proteins measured before the malaria season were significantly higher in 8–10-year-old children who were infected with Pf during the malaria season but did not experience malaria ( n = 12) vs. those who experienced malaria ( n = 29). This analysis also provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features. This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets.
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Cited by
Coutant, F., Sanchez David, R. Y., Félix, T., Boulay, A., Caleechurn, L., Souque, P., Thouvenot, C., Bourgouin, C., Beignon, A.-S., & Charneau, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048644 · Cited by 32
Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women
Teo, A., Hasang, W., Randall, L. M., Feng, G., Bell, L., Unger, H., Langer, C., Beeson, J. G., Siba, P. M., Mueller, I., et al. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu264 · Cited by 25
Garza, R., Marchioni, J. M., Honeycutt, J. D., Hurlburt, N. K., Torres, C., Garcia, A., Neog, S., Loranc, E., Yemington, E., Towers, D., et al. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052979 · Cited by 1
Metadata
- Authors
- Crompton, P. D., Kayala, M. A., Traore, B., Kayentao, K., Ongoiba, A., Weiss, G. E., Molina, D. M., Burk, C. R., Waisberg, M., Jasinskas, A., Tan, X., Doumbo, S., Doumtabe, D., Kone, Y., Narum, D. L., Liang, X., Doumbo, O. K., Miller, L. H., Doolan, D. L., Baldi, P., Felgner, P. L., & Pierce, S. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-03-29
- Volume
- 107
- Issue
- 15
- Pages
- 6958-6963
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2125264382
- Cited by
- 420
- References
- 38
- FWCI
- 31.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Crompton, P. D., Kayala, M. A., Traore, B., Kayentao, K., Ongoiba, A., Weiss, G. E., Molina, D. M., Burk, C. R., Waisberg, M., Jasinskas, A., Tan, X., Doumbo, S., Doumtabe, D., Kone, Y., Narum, D. L., Liang, X., Doumbo, O. K., Miller, L. H., Doolan, D. L., . . . Pierce, S. K. (2010). A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1001323107
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