Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women
Abstract
BACKGROUND: As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of protective antibody. METHODS: Plasma samples were collected from Malawian and Papua New Guinean (PNG) pregnant women enrolled over 7-year periods, during which malaria prevalence fell by over two thirds. Immunoglobulin G (IgG) levels to schizont extract, merozoite antigens, and VAR2CSA-DBL5ε were measured by enzyme-linked immunosorbent assay (ELISA). Levels of IgG to variant surface antigens of infected erythrocytes (IEs) and merozoites and levels of opsonizing IgG to IEs were measured by flow cytometry. RESULTS: In both settings, levels of antibodies in pregnant women to recombinant antigens and to intact IEs but not of opsonizing antibodies decreased over time. After adjustment for coverage with insecticide-treated bed nets (ITNs), these differences disappeared in the Malawian cohort, whereas in the PNG cohort, time was independently associated with a decrease in several antibody responses measured by ELISA. CONCLUSIONS: The impact of falling parasite prevalence on anti-Plasmodium falciparum serological indicators in pregnant women varies by setting. Increased ITN coverage may affect development of antibodies to recombinant antigens, but levels of opsonizing IgG remained stable over time. Opsonizing IgG against placental-binding IEs may persist, thus offering longer-lasting protection against malaria during pregnancy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The prevalence of malaria in pregnant women in this study was lower than previously observed.
“In addition, the prevalence of malaria in pregnant women was lower than previously observed [28, 36], probably because of the intensified malaria control strategies during the study period [49, 50].”
Cites
Bulletin of the World Health Organization
C., N. H. (1955) · British Journal of Sociology · doi:10.2307/587237 · Cited by 3,663 · see citing works
Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)
Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T., & Tada, K. (1980) · International Journal of Cancer · doi:10.1002/ijc.2910260208 · Cited by 2,258 · see citing works
Epidemiology and burden of malaria in pregnancy
Desai, M., ter Kuile, F. O., Nosten, F., McGready, R., Asamoa, K., Brabin, B., & Newman, R. D. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70021-x · Cited by 1,432 · see citing works
Adherence of <i>Plasmodium falciparum</i> to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108 · see citing works
An analysis of malaria in pregnancy in Africa.
Brabin, B. J. (1983) · PubMed · Cited by 785 · see citing works
Maternal antibodies block malaria
Fried, M., Nosten, F., Brockman, A., Brabin, B. J., & Duffy, P. E. (1998) · Nature · doi:10.1038/27570 · Cited by 659 · see citing works
Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria
Salanti, A., Dahlbäck, M., Turner, L., Nielsen, M. A., Barfod, L., Magistrado, P., Jensen, A. T. R., Lavstsen, T., Ofori, M. F., Marsh, K., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041579 · Cited by 604 · see citing works
Crompton, P. D., Kayala, M. A., Traoré, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001323107 · Cited by 421 · see citing works
Osier, F. H. A., Fegan, G., Polley, S. D., Murungi, L., Verra, F., Tetteh, K. K. A., Lowe, B. S., Mwangi, T., Bull, P. C., Thomas, A. W., et al. (2008) · Infection and Immunity · doi:10.1128/iai.01585-07 · Cited by 387 · see citing works
Boyle, M. J., Wilson, D. W., Richards, J. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009198107 · Cited by 318 · see citing works
Ricke, C. H., Staalsoe, T., Koram, K., Akanmori, B. D., Riley, E. M., Theander, T. G., & Hviid, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3309 · Cited by 303 · see citing works
Staalsoe, T., Shulman, C. E., Bulmer, J. N., Kawuondo, K., Marsh, K., & Hviid, L. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15386-x · Cited by 288 · see citing works
ROGERSON, S. J., POLLINA, E., GETACHEW, A., TADESSE, E., LEMA, V. M., & MOLYNEUX, M. E. (2003) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2003.68.1.0680115 · Cited by 275 · see citing works
Self-citationBeeson, J. G., Brown, G. V., Molyneux, M. E., Mhango, C., Dzinjalamala, F., & Rogerson, S. J. (1999) · The Journal of Infectious Diseases · doi:10.1086/314899 · Cited by 266 · see citing works
Self-citationDuffy, P. E., & Fried, M. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6620-6623.2003 · Cited by 260 · see citing works
Stanisic, D. I., Richards, J. S., McCallum, F. J., Michon, P., King, C. L., Schoepflin, S., Gilson, P. R., Murphy, V. J., Anders, R. F., Müeller, I., et al. (2009) · Infection and Immunity · doi:10.1128/iai.01129-08 · Cited by 257 · see citing works
Self-citationKinyanjui, S., Conway, D. J., Lanar, D. E., et al. (2007) · Malaria Journal · doi:10.1186/1475-2875-6-82 · Cited by 190 · see citing works
Persson, K. E. M., McCallum, F. J., Reiling, L., Lister, N. A., Stubbs, J., Cowman, A. F., Marsh, K., & Beeson, J. G. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32138 · Cited by 188 · see citing works
Self-citationMalaria in pregnancy in the Asia-Pacific region
Rijken, M. J., McGready, R., Boel, M. E., Poespoprodjo, R., Singh, N., Syafruddin, D., Rogerson, S., & Nosten, F. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70315-2 · Cited by 181 · see citing works
Self-citationAkpogheneta, O. J., Duah-Quashie, N. O., Tetteh, K. K. A., et al. (2008) · Infection and Immunity · doi:10.1128/iai.01333-07 · Cited by 176 · see citing works
Staalsoe, T., Megnekou, R., Fievét, N., Ricke, C. H., Zornig, H. D., Leke, R., Taylor, D. W., Deloron, P., & Hviid, L. (2001) · The Journal of Infectious Diseases · doi:10.1086/322809 · Cited by 161 · see citing works
Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection.
Mount, A. M., Mwapasa, V., Elliott, S. R., Beeson, J. G., Tadesse, E., Lema, V. M., Molyneux, M. E., Meshnick, S. R., & Rogerson, S. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16354-x · Cited by 144 · see citing works
Self-citationBeeson, J. G., Mann, E. J., Elliott, S. R., Lema, V. M., Tadesse, E., Molyneux, M. E., Brown, G. V., & Rogerson, S. J. (2004) · The Journal of Infectious Diseases · doi:10.1086/381186 · Cited by 109 · see citing works
Self-citationOpsonising Antibodies to P. falciparum Merozoites Associated with Immunity to Clinical Malaria
Hill, D. L., Eriksson, E. M., Suen, C. S. N. L. W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074627 · Cited by 104 · see citing works
New Insights into Acquisition, Boosting, and Longevity of Immunity to Malaria in Pregnant Women
Fowkes, F. J., McGready, R., Cross, N. J., Hommel, M., Simpson, J. A., Elliott, S. R., Richards, J. S., Lackovic, K., Viladpai-Nguen, J., Narum, D., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis566 · Cited by 101 · see citing works
Self-citationReiling, L., Richards, J. S., Fowkes, F. J. I., Barry, A. E., Triglia, T., Chokejindachai, W., Michon, P., Tavul, L., Siba, P. M., Cowman, A. F., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001555 · Cited by 92 · see citing works
Self-citationFeng, G., Simpson, J. A., Chaluluka, E., Molyneux, M. E., & Rogerson, S. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012012 · Cited by 90 · see citing works
Self-citationFeng, G., Aitken, E., Yosaatmadja, F., Kalilani, L., Meshnick, S. R., Jaworowski, A., Simpson, J. A., & Rogerson, S. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/599841 · Cited by 69 · see citing works
Self-citationParasite adhesion and immune evasion in placental malaria
Beeson, J. G., Reeder, J. C., Rogerson, S. J., & Brown, G. V. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(01)01917-1 · Cited by 68 · see citing works
Self-citationMagistrado, P., Salanti, A., Tuikue Ndam, N. G., Mwakalinga, S. B., Resende, M., Dahlbäck, M., Hviid, L., Lusingu, J., Theander, T. G., & Nielsen, M. A. (2008) · The Journal of Infectious Diseases · doi:10.1086/591502 · Cited by 61 · see citing works
Ataíde, R., Hasang, W., Wilson, D. W., Beeson, J. G., Mwapasa, V., Molyneux, M. E., Meshnick, S. R., & Rogerson, S. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010807 · Cited by 59 · see citing works
Self-citationAtaíde, R., Mwapasa, V., Molyneux, M. E., Meshnick, S. R., & Rogerson, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022491 · Cited by 45 · see citing works
Self-citationMayor, A. G., Kumar, U., Bardají, A., Gupta, P., Jiménez, A., Hamad, A., Sigaúque, B., Singh, B., Quintó, L., Kumar, S., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit083 · Cited by 45 · see citing works
Chandrasiri, U., Randall, L. M., Saad, A. A., Bashir, A. M., Rogerson, S. J., & Adam, I. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit646 · Cited by 43 · see citing works
Self-citationAitken, E. H., Mbewe, B., Luntamo, M., Maleta, K. M., Kulmala, T., Friso, M., Fowkes, F. J. I., Beeson, J. G., Ashorn, P., & Rogerson, S. J. (2010) · The Journal of Infectious Diseases · doi:10.1086/651578 · Cited by 42 · see citing works
Self-citationAvril, M., Cartwright, M. M., Hathaway, M. J., Hommel, M., Elliott, S. R., Williamson, K., Narum, D. L., Duffy, P. E., Fried, M., Beeson, J. G., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00410-09 · Cited by 39 · see citing works
Self-citationFernández, P. M., Pêtres, S., Mécheri, S., Gysin, J., & Scherf, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012558 · Cited by 36 · see citing works
Fonjungo, P. N., Elhassan, I. M., Cavanagh, D. R., et al. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2975-2985.1999 · Cited by 36 · see citing works
The case for PfEMP1-based vaccines to protect pregnant women againstPlasmodium falciparummalaria
Hviid, L. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.113 · Cited by 35 · see citing works
Staalsøe, T., Shulman, C. E., Dorman, E. K., Kawuondo, K., Marsh, K., & Hviid, L. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5027-5030.2004 · Cited by 34 · see citing works
Moncunill, G., Mayor, A. G., Jiménez, A., Nhabomba, A. J., Casas-Vila, N., Puyol, L., Campo, J. J., Manaca, M. N., Aguilar, R., Pinazo, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073624 · Cited by 31 · see citing works
Nébié, I., Tiono, A. B., Diallo, D. A., et al. (2008) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2007.01994.x · Cited by 30 · see citing works
Vestergaard, L. S., Lusingu, J., Nielsen, M. A., Mmbando, B. P., Dodoo, D., Akanmori, B. D., Alifrangis, M., Bygbjerg, I. C., Lemnge, M. M., Staalsøe, T., et al. (2008) · Infection and Immunity · doi:10.1128/iai.01401-06 · Cited by 30 · see citing works
Aitken, E. H., Mbewe, B., Luntamo, M., Kulmala, T., Beeson, J. G., Ashorn, P., & Rogerson, S. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029874 · Cited by 20 · see citing works
Self-citationGnidehou, S., Jessen, L. E., Gangnard, S., Ermont, C., Triqui, C., Quiviger, M., Guitard, J., Lund, O., Deloron, P., & Ndam, N. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013105 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Atwell, J. E., Thumar, B., Robinson, L. J., Tobby, R., Yambo, P., Ome-Kaius, M., Siba, P. M., Unger, H. W., Rogerson, S. J., King, C. L., et al. (2016) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv401 · Cited by 48 · see citing works
Self-citationUmbers, A. J., Unger, H. W., Rosanas-Urgell, A., Wangnapi, R. A., Kattenberg, J. H., Jally, S., Silim, S., Lufele, E., Karl, S., Ome-Kaius, M., et al. (2015) · Malaria Journal · doi:10.1186/s12936-015-0927-5 · Cited by 37 · see citing works
Self-citation
- Authors
- Teo, A., Hasang, W., Randall, L. M., Feng, G., Bell, L., Unger, H., Langer, C., Beeson, J. G., Siba, P. M., Mueller, I., Molyneux, M. E., Brown, G. V., & Rogerson, S. J.
- Affiliations
- Peter Doherty Institute (AU)
- Burnet Institute (AU)
- The University of Melbourne (AU)
- Papua New Guinea Institute of Medical Research (PG)
- Liverpool School of Tropical Medicine (GB)
- Corresponding author
- Teo, A.
- ORCID
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-05
- Volume
- 210
- Issue
- 9
- Pages
- 1444-1455
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2128432060
- Cited by
- 25
- References
- 45
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2017: 2 · 2016: 3 · 2015: 10
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (101113)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- malaria in pregnancy, Plasmodium falciparum, antibody response, seroconversion, VAR2CSA, placental malaria, merozoite antigens, schizont antigens, variant surface antigens, insecticide-treated nets, maternal immunity, Malawi, Papua New Guinea
- MeSH terms
- Adult, Antibodies, Protozoan, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Immunoglobulin G, Immunity, Innate, Malawi, Papua New Guinea, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Prevalence, Malaria, Falciparum, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review