Cited by 25Malaria Research and ControlBlood groups and transfusionVector-borne infectious diseases

Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women

Teo, A., Hasang, W., Randall, L. M., Feng, G., Bell, L., Unger, H., Langer, C., Beeson, J. G. +5 more·2014·Journal of Infectious Diseases

Abstract

BACKGROUND: As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of protective antibody. METHODS: Plasma samples were collected from Malawian and Papua New Guinean (PNG) pregnant women enrolled over 7-year periods, during which malaria prevalence fell by over two thirds. Immunoglobulin G (IgG) levels to schizont extract, merozoite antigens, and VAR2CSA-DBL5ε were measured by enzyme-linked immunosorbent assay (ELISA). Levels of IgG to variant surface antigens of infected erythrocytes (IEs) and merozoites and levels of opsonizing IgG to IEs were measured by flow cytometry. RESULTS: In both settings, levels of antibodies in pregnant women to recombinant antigens and to intact IEs but not of opsonizing antibodies decreased over time. After adjustment for coverage with insecticide-treated bed nets (ITNs), these differences disappeared in the Malawian cohort, whereas in the PNG cohort, time was independently associated with a decrease in several antibody responses measured by ELISA. CONCLUSIONS: The impact of falling parasite prevalence on anti-Plasmodium falciparum serological indicators in pregnant women varies by setting. Increased ITN coverage may affect development of antibodies to recombinant antigens, but levels of opsonizing IgG remained stable over time. Opsonizing IgG against placental-binding IEs may persist, thus offering longer-lasting protection against malaria during pregnancy.

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Crossref · 10.1093/infdis/jiu264

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Authors
Teo, A., Hasang, W., Randall, L. M., Feng, G., Bell, L., Unger, H., Langer, C., Beeson, J. G., Siba, P. M., Mueller, I., Molyneux, M. E., Brown, G. V., & Rogerson, S. J.
Affiliations
  • Peter Doherty Institute (AU)
  • Burnet Institute (AU)
  • The University of Melbourne (AU)
  • Papua New Guinea Institute of Medical Research (PG)
  • Liverpool School of Tropical Medicine (GB)
Corresponding author
Teo, A.
Venue
Journal of Infectious Diseases
Published
2014-05-05
Volume
210
Issue
9
Pages
1444-1455
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2128432060
Cited by
25
References
45
Citations by year
2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2017: 2 · 2016: 3 · 2015: 10
FWCI
4.95
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust (101113)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Hematology › Blood groups and transfusion
  • Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords
malaria in pregnancy, Plasmodium falciparum, antibody response, seroconversion, VAR2CSA, placental malaria, merozoite antigens, schizont antigens, variant surface antigens, insecticide-treated nets, maternal immunity, Malawi, Papua New Guinea
MeSH terms
Adult, Antibodies, Protozoan, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Immunoglobulin G, Immunity, Innate, Malawi, Papua New Guinea, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Prevalence, Malaria, Falciparum, Young Adult

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