The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway
Open accessAbstract
Piwi-interacting RNAs (piRNAs) are essential for silencing of transposable elements in the germline, but their biogenesis is poorly understood. Here we demonstrate that MOV10L1, a germ cell–specific putative RNA helicase, is associated with Piwi proteins. Genetic disruption of the MOV10L1 RNA helicase domain in mice renders both MILI and MIWI2 devoid of piRNAs. Absence of a functional piRNA pathway in Mov10l1 mutant testes causes loss of DNA methylation and subsequent derepression of retrotransposons in germ cells. The Mov10l1 mutant males are sterile owing to complete meiotic arrest. This mouse mutant expresses Piwi proteins but lacks piRNAs, suggesting that MOV10L1 is required for piRNA biogenesis and/or loading to Piwi proteins.
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Citations
Cites
A germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
Self-citationA novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096
Cited by
A census of human RNA-binding proteins
Gerstberger, S., Hafner, M., & Tuschl, T. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3813 · Cited by 2,032
PIWI-interacting small RNAs: the vanguard of genome defence
Siomi, M. C., Sato, K., Pezic, D., & Aravin, A. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3089 · Cited by 1,319
Regulation and function of DNA methylation in plants and animals
He, X.-J., Chen, T., & Zhu, J.-K. (2011) · Cell Research · doi:10.1038/cr.2011.23 · Cited by 555
Restricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436
Watanabe, T., Chuma, S., Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.005 · Cited by 305
Metadata
- Authors
- Zheng, K., Xiol, J., Reuter, M., Eckardt, S., Leu, N. A., McLaughlin, K. J., Stark, A., Sachidanandam, R., Pillai, R. S., & Wang, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-06
- Volume
- 107
- Issue
- 26
- Pages
- 11841-11846
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021243703
- Cited by
- 214
- References
- 3
- FWCI
- 18.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, K., Xiol, J., Reuter, M., Eckardt, S., Leu, N. A., McLaughlin, K. J., Stark, A., Sachidanandam, R., Pillai, R. S., & Wang, P. J. (2010). Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1003953107
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