Peptide secondary structure modulates single-walled carbon nanotube fluorescence as a chaperone sensor for nitroaromatics
Open accessAbstract
A class of peptides from the bombolitin family, not previously identified for nitroaromatic recognition, allows near-infrared fluorescent single-walled carbon nanotubes to transduce specific changes in their conformation. In response to the binding of specific nitroaromatic species, such peptide–nanotube complexes form a virtual “chaperone sensor,” which reports modulation of the peptide secondary structure via changes in single-walled carbon nanotubes, near-infrared photoluminescence. A split-channel microscope constructed to image quantized spectral wavelength shifts in real time, in response to nitroaromatic adsorption, results in the first single-nanotube imaging of solvatochromic events. The described indirect detection mechanism, as well as an additional exciton quenching-based optical nitroaromatic detection method, illustrate that functionalization of the carbon nanotube surface can result in completely unique sites for recognition, resolvable at the single-molecule level.
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Fluorescence modulation of single-walled carbon nanotubes is caused by several mechanisms, including Fermi level shifting through modulation of the immediate redox environment, exciton disruption in response to binding events, and solvatochromic shifting due to perturbation of the local dielectric environment.
“The fluorescence modulation of SWCNTs is caused by several mechanisms, including Fermi level shifting through modulation of the immediate redox environment and exciton disruption in response to binding events, which change SWCNT intensity, and solvatochromic (wavelength) shifting due to perturbation of the local dielectric environment, including shifts due to modulation of the local electrostatic”
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- Authors
- Heller, D. A., Pratt, G. W., Zhang, J., Nair, N., Hansborough, A. J., Boghossian, A. A., Reuel, N. F., Barone, P. W., & Strano, M. S.
- Affiliations
- Massachusetts Institute of Technology (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-05-09
- Volume
- 108
- Issue
- 21
- Pages
- 8544-8549
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3102399
- OpenAlex
- W2056525779
- Cited by
- 146
- References
- 32
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 19 · 2023: 14 · 2022: 11 · 2021: 13 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 10 · 2014: 1 · 2013: 10 · 2012: 10
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (5p50gm068762-10)
- National Institute of General Medical Sciences (GM 68762, P50-GM068762)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- single-walled carbon nanotubes, peptide secondary structure, nitroaromatic compounds, near-infrared fluorescence, solvatochromism, exciton quenching, nanotube functionalization, chemical sensing
- MeSH terms
- Adsorption, Fluorescence, Hydrocarbons, Aromatic, Microscopy, Nitro Compounds, Peptides, Protein Structure, Secondary, Molecular Chaperones, Nanotubes, Carbon
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