Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation
Open accessAbstract
Cell adhesion is a protein-mediated process intrinsic to most living organisms. Dysfunction in cell adhesion processes is implicated in various diseases, including thrombosis and metastatic cancers. Using an approach to resolve spectral features from cell membrane-associated photoluminescent single-walled carbon nanotubes, we found that nanotube optical bandgaps respond to the electrostatic potential of the cell surface, which corresponds to cell adhesion properties. We studied the carbon nanotube emission energy response to solution ionic potentials, which suggests sensitivity to local charge accumulation. We conclude that nanotubes respond to cell surface electrostatic potentials that are mediated by membrane proteins, which vary significantly across cell types. These findings portend the optical measurement of surface electrostatic potentials for biophysical measurements and biomedical applications.
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Fluorescence modulation of single-walled carbon nanotubes is caused by several mechanisms, including Fermi level shifting through modulation of the immediate redox environment, exciton disruption in response to binding events, and solvatochromic shifting due to perturbation of the local dielectric environment.
“The fluorescence modulation of SWCNTs is caused by several mechanisms, including Fermi level shifting through modulation of the immediate redox environment and exciton disruption in response to binding events, which change SWCNT intensity, and solvatochromic (wavelength) shifting due to perturbation of the local dielectric environment, including shifts due to modulation of the local electrostatic”
From Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning (2022) · cites this paper as [24]
The emission of SWCNTs (E11) is sensitive to dielectric environments, redox perturbations and electrostatic charge.
“The emission of SWCNTs (E11) is sensitive to dielectric environments21,22, redox perturbations23 and electrostatic charge24,25.”
From Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning (2022) · cites this paper as [24]
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- Authors
- Roxbury, D., Jena, P. V., Shamay, Y., Horoszko, C. P., & Heller, D. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Heller, Daniel A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-12-11
- Volume
- 10
- Issue
- 1
- Pages
- 499-506
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- PMC
- PMC4975035
- OpenAlex
- W2215522337
- Cited by
- 74
- References
- 38
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 10 · 2020: 4 · 2019: 12 · 2018: 7 · 2017: 14 · 2016: 2
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30 CA008748)
- Honorable Tina Brozman Foundation
- National Institute of Child Health and Human Development (DP2-HD075698)
- American Cancer Society (PF-13-388-01-TBG)
- Alan and Sandra Gerry Metastasis Research Initiative
- Center for Molecular Imaging and Nanotechnology, Memorial Sloan-Kettering Cancer Center
- Commonwealth Foundation for Cancer Research
- Center for Experimental Therapeutics, Memorial Sloan Kettering Cancer Center
- Louis V. Gerstner, Jr. Young Investigators Fund
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Graphene research and applications
- Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- single-walled carbon nanotubes, optical band gap, surface charge accumulation, plasma membrane proteins, cell adhesion, photoluminescence, ionic strength, cell type specificity
- MeSH terms
- Animals, Cell Adhesion, Humans, Luminescent Measurements, Membrane Proteins, Organ Specificity, Spectrophotometry, Infrared, Surface Properties, Thermodynamics, Jurkat Cells, Nanotubes, Carbon, NIH 3T3 Cells, Mice, Static Electricity, Molecular Imaging, Time-Lapse Imaging
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