Cited by 505Advanced biosensing and bioanalysis techniquesCarbon Nanotubes in CompositesDNA and Nucleic Acid Chemistry

Optical Detection of DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes

Heller, Daniel A., Jeng, Esther S., Yeung, Tsun-Kwan, Martinez, Brittany M., Moll, Anthonie E., Gastala, Joseph B., Strano, Michael S.·2006·Science

Abstract

The transition of DNA secondary structure from an analogous B to Z conformation modulates the dielectric environment of the single-walled carbon nanotube (SWNT) around which it is adsorbed. The SWNT band-gap fluorescence undergoes a red shift when an encapsulating 30-nucleotide oligomer is exposed to counter ions that screen the charged backbone. The transition is thermodynamically identical for DNA on and off the nanotube, except that the propagation length of the former is shorter by five-sixths. The magnitude of the energy shift is described by using an effective medium model and the DNA geometry on the nanotube sidewall. We demonstrate the detection of the B-Z change in whole blood, tissue, and from within living mammalian cells.

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Crossref · 10.1126/science.1120792

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Authors
Heller, D. A., Jeng, E. S., Yeung, T.-K., Martinez, B. M., Moll, A. E., Gastala, J. B., & Strano, M. S.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Strano, Michael S.
Venue
Science
Published
2006-01-27
Volume
311
Issue
5760
Pages
508-511
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2092536024
Cited by
505
References
21
Citations by year
2026: 13 · 2025: 9 · 2024: 10 · 2023: 4 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 18 · 2018: 27 · 2017: 22 · 2016: 24 · 2015: 22 · 2014: 14 · 2013: 36 · 2012: 35
FWCI
20.14
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Physical Sciences › Materials Science › Materials Chemistry › Carbon Nanotubes in Composites
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
single-walled carbon nanotubes, DNA conformational polymorphism, B-Z DNA transition, dielectric environment, effective medium model, whole blood, living mammalian cells
MeSH terms
Absorption, Adsorption, Animals, Cations, Divalent, Chickens, Circular Dichroism, DNA, Fluorescence, Mathematics, Mercury, Models, Molecular, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Spectrometry, Fluorescence, Thermodynamics, 3T3 Cells, Muscle, Skeletal, Nanotubes, Carbon, DNA, Z-Form, Mice

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